OMIA:002612-9823 : MYF5/MYOD/MYF6 deficiency in Sus scrofa (pig)
Categories: Muscle phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: unknown
Species-specific description: Maeng et al. (2021) "show that intraspecies and interspecies chimaeric pig embryos lacking native skeletal muscle can be produced by deleting the MYF5, MYOD and MYF6 genes in the embryos via CRISPR, followed by somatic-cell nuclear transfer and the delivery of exogenous cells ... via blastocyst complementation. The generated intraspecies chimaeras were viable and displayed normal histology, morphology and function. ... Human:pig chimaeras may facilitate the production of exogenic organs for research and xenotransplantation. "
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2021||Maeng, G., Das, S., Greising, S.M., Gong, W., Singh, B.N., Kren, S., Mickelson, D., Skie, E., Gafni, O., Sorensen, J.R., Weaver, C.V., Garry, D.J., Garry, M.G. :|
|Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos. Nat Biomed Eng 5:805-814, 2021. Pubmed reference: 33782573. DOI: 10.1038/s41551-021-00693-1.|
- Created by Imke Tammen2 on 19 Jan 2023