OMIA:002612-9823 : MYF5/MYOD/MYF6 deficiency in Sus scrofa (pig)

Categories: Muscle phene

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific description: Maeng et al. (2021) "show that intraspecies and interspecies chimaeric pig embryos lacking native skeletal muscle can be produced by deleting the MYF5, MYOD and MYF6 genes in the embryos via CRISPR, followed by somatic-cell nuclear transfer and the delivery of exogenous cells ... via blastocyst complementation. The generated intraspecies chimaeras were viable and displayed normal histology, morphology and function. ... Human:pig chimaeras may facilitate the production of exogenic organs for research and xenotransplantation. " This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002612-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2021 Maeng, G., Das, S., Greising, S.M., Gong, W., Singh, B.N., Kren, S., Mickelson, D., Skie, E., Gafni, O., Sorensen, J.R., Weaver, C.V., Garry, D.J., Garry, M.G. :
Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos. Nat Biomed Eng 5:805-814, 2021. Pubmed reference: 33782573. DOI: 10.1038/s41551-021-00693-1.

Edit History

  • Created by Imke Tammen2 on 19 Jan 2023
  • Changed by Imke Tammen2 on 18 Dec 2023