OMIA:002613-9823 : Lactoferrin concentration, increased in Sus scrofa (pig)
Possibly relevant human trait(s) and/or gene(s) (MIM number): 150210 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: unknown
Species-specific description: Han et al. (2020): "constructed genome-edited Large-White pigs with marker-free site-specific knock-in of lactoferrin gene in the 3'-end of Casein alpha-s1 via CRISPR/Cas9 mediated homologous recombination. Thus, the lactoferrin protein can be expressed in the mammary gland in the control of Casein alpha-s1 promoter. As expected, the lactoferrin protein in genetically modified pigs sustained high expression in both colostrum and milk when compared with wild-type pigs."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2020||Han, X., Gao, Y., Li, G., Xiong, Y., Zhao, C., Ruan, J., Ma, Y., Li, X., Li, C., Zhao, S., Xie, S. :|
|Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology. Cell Biosci 10:133, 2020. Pubmed reference: 33292594. DOI: 10.1186/s13578-020-00496-y.|
- Created by Imke Tammen2 on 19 Jan 2023
- Changed by Imke Tammen2 on 19 Jan 2023