OMIA:002613-9823 : Lactoferrin concentration in Sus scrofa (pig)

In other species: taurine cattle

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s) (MIM number): 150210 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific description: Han et al. (2020): "constructed genome-edited Large-White pigs with marker-free site-specific knock-in of lactoferrin gene in the 3'-end of Casein alpha-s1 via CRISPR/Cas9 mediated homologous recombination. Thus, the lactoferrin protein can be expressed in the mammary gland in the control of Casein alpha-s1 promoter. As expected, the lactoferrin protein in genetically modified pigs sustained high expression in both colostrum and milk when compared with wild-type pigs." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002613-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2020 Han, X., Gao, Y., Li, G., Xiong, Y., Zhao, C., Ruan, J., Ma, Y., Li, X., Li, C., Zhao, S., Xie, S. :
Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology. Cell Biosci 10:133, 2020. Pubmed reference: 33292594. DOI: 10.1186/s13578-020-00496-y.

Edit History

  • Created by Imke Tammen2 on 19 Jan 2023
  • Changed by Imke Tammen2 on 19 Jan 2023
  • Changed by Imke Tammen2 on 18 Dec 2023