OMIA:002613-9823 : Lactoferrin concentration, increased in Sus scrofa (pig) |
Categories: Endocrine / exocrine gland phene (incl mammary gland)
Possibly relevant human trait(s) and/or gene(s) (MIM number): 150210 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: unknown
Species-specific description: Han et al. (2020): "constructed genome-edited Large-White pigs with marker-free site-specific knock-in of lactoferrin gene in the 3'-end of Casein alpha-s1 via CRISPR/Cas9 mediated homologous recombination. Thus, the lactoferrin protein can be expressed in the mammary gland in the control of Casein alpha-s1 promoter. As expected, the lactoferrin protein in genetically modified pigs sustained high expression in both colostrum and milk when compared with wild-type pigs."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002613-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2020 | Han, X., Gao, Y., Li, G., Xiong, Y., Zhao, C., Ruan, J., Ma, Y., Li, X., Li, C., Zhao, S., Xie, S. : |
| Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology. Cell Biosci 10:133, 2020. Pubmed reference: 33292594. DOI: 10.1186/s13578-020-00496-y. |
Edit History
- Created by Imke Tammen2 on 19 Jan 2023
- Changed by Imke Tammen2 on 19 Jan 2023