OMIA:002613-9823 : Lactoferrin concentration, increased in Sus scrofa (pig)

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s) (MIM number): 150210 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific description: Han et al. (2020): "constructed genome-edited Large-White pigs with marker-free site-specific knock-in of lactoferrin gene in the 3'-end of Casein alpha-s1 via CRISPR/Cas9 mediated homologous recombination. Thus, the lactoferrin protein can be expressed in the mammary gland in the control of Casein alpha-s1 promoter. As expected, the lactoferrin protein in genetically modified pigs sustained high expression in both colostrum and milk when compared with wild-type pigs."

This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002613-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2020 Han, X., Gao, Y., Li, G., Xiong, Y., Zhao, C., Ruan, J., Ma, Y., Li, X., Li, C., Zhao, S., Xie, S. :
Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology. Cell Biosci 10:133, 2020. Pubmed reference: 33292594. DOI: 10.1186/s13578-020-00496-y.

Edit History

  • Created by Imke Tammen2 on 19 Jan 2023
  • Changed by Imke Tammen2 on 19 Jan 2023