OMIA:002619-9823 : Hypogonadotropic hypogonadism, KISS1-related in Sus scrofa (pig)

Categories: Reproductive system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 603286 (gene) , 614842 (trait)

Links to MONDO diseases:

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: Flórez et al. (2023) generated KISS1-edited pigs using CRISPR/Cas9 genome editing as an alternative to the need to surgically castrate pigs to avoid puberty-derived boar taint and aggressiveness: ".... four KISS1-edited pigs (two boars and two gilts) with disruptive allele frequencies of 96% and 100% demonstrated full hypogonadotropism, infantile reproductive tracts, and failed to reach sexual maturity." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Duroc (Pig) (VBO_0001127), Yorkshire (Pig) (VBO_0001212).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
KISS1 KiSS-1 metastasis-suppressor Sus scrofa 9 NC_010451.4 (64841071..64834822) KISS1 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002619-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2022 Flórez, J.M., Martins, K., Solin, S., Bostrom, J.R., Rodríguez-Villamil, P., Ongaratto, F., Larson, S.A., Ganbaatar, U., Coutts, A.W., Kern, D., Murphy, T.W., Kim, E.S., Carlson, D.F., Huisman, A., Sonstegard, T.S., Lents, C.A. :
CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait. Front Genet 13:1078991, 2022. Pubmed reference: 36685939. DOI: 10.3389/fgene.2022.1078991.

Edit History

  • Created by Imke Tammen2 on 01 Feb 2023
  • Changed by Imke Tammen2 on 18 Dec 2023