OMIA:002619-9823 : Hypogonadotropic hypogonadism, KISS1-related in Sus scrofa (pig)
Categories: Reproductive system phene
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: Flórez et al. (2023) generated KISS1-edited pigs using CRISPR/Cas9 genome editing as an alternative to the need to surgically castrate pigs to avoid puberty-derived boar taint and aggressiveness: ".... four KISS1-edited pigs (two boars and two gilts) with disruptive allele frequencies of 96% and 100% demonstrated full hypogonadotropism, infantile reproductive tracts, and failed to reach sexual maturity."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Duroc (Pig) (VBO_0001127),
Yorkshire (Pig) (VBO_0001212).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|KISS1||KiSS-1 metastasis-suppressor||Sus scrofa||9||NC_010451.4 (64841071..64834822)||KISS1||Homologene, Ensembl , NCBI gene|
Cite this entry
|2022||Flórez, J.M., Martins, K., Solin, S., Bostrom, J.R., Rodríguez-Villamil, P., Ongaratto, F., Larson, S.A., Ganbaatar, U., Coutts, A.W., Kern, D., Murphy, T.W., Kim, E.S., Carlson, D.F., Huisman, A., Sonstegard, T.S., Lents, C.A. :|
|CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait. Front Genet 13:1078991, 2022. Pubmed reference: 36685939 . DOI: 10.3389/fgene.2022.1078991.|
- Created by Imke Tammen2 on 01 Feb 2023