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OMIA:002628-215402 : Skin colour, albinism, oculocutaneous type IV in Channa argus (northern snakehead)

In other species: Atlantic salmon , redhead cichlid , royal farlowella

Categories: Pigmentation phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606574 (trait) , 606202 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Disease-related: no

Key variant known: yes

Year key variant first reported: 2023

Species-specific name: yellow skin, yellow-mutant

Species-specific symbol: YM

Species-specific description: Sun et al. (2023): "During the breeding of C. argus, three varieties with distinct colour morphs have been discovered in Chinese aquaculture industry, including the wild-type (WT) with greyish-black body colour .... , the widely reported white-albino strain with stable inheritance of the white skin [Zhou et al. 2020, see OMIA:002437-215402] and the newly discovered strain with the golden yellow skin ... ."

Molecular basis: Sun et al. (2023): "By applying genomic analysis approaches, in combination with gene knockdown and rescue experiments, we suggested a non-sense mutation in slc45a2 (c.383G > A) is the causation for the YM [yellow skin] snakehead."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SLC45A2 Channa argus 18 NC_090214.1 (7224828..7207650) SLC45A2 Homologene, Ensembl , NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
1530 Skin colour, yellow SLC45A2 YM nonsense (stop-gain) Naturally occurring variant 19 c.383G>A p.(W128*) 2023 36789536
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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002628-215402: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Sun, D., Qi, X., Wen, H., Li, C., Li, J., Chen, J., Tao, Z., Zhu, M., Zhang, X., Li, Y. :
The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus). Open Biol 13:220235, 2023. Pubmed reference: 36789536. DOI: 10.1098/rsob.220235.
2020 Zhou, A., Xie, S., Feng, Y., Sun, D., Liu, S., Sun, Z., Li, M., Zhang, C., Zou, J. :
Insights into the albinism mechanism for two distinct color morphs of Northern Snakehead, Channa argus through histological and transcriptome analyses. Front Genet 11:830, 2020. Pubmed reference: 33193565. DOI: 10.3389/fgene.2020.00830.

Edit History


  • Created by Imke Tammen2 on 17 Feb 2023
  • Changed by Imke Tammen2 on 17 Feb 2023
  • Changed by Imke Tammen2 on 25 Mar 2023