OMIA:002628-8030 : Skin colour, albinism, oculocutaneous type IV in Salmo salar (Atlantic salmon)
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: unknown
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: Raudstein et al. (2023) microinjected salmon embryos with LbCas12a ribonucleoprotein complexes targeting the pigmentation gene solute carrier family 45 member 2 (slc45a2). Using CRISPR/LbCas12a, [the authors] were able to knock-out slc45a2 and knock-in a FLAG sequence element by providing single-stranded DNA templates." This study involves genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|slc45a2||solute carrier family 45, member 2||Salmo salar||ssa01||NC_059442.1 (131423988..131398604)||slc45a2||Homologene, Ensembl , NCBI gene|
Cite this entry
|2023||Raudstein, M., Kjærner-Semb, E., Barvik, M., Broll, S., Straume, A.H., Edvardsen, R.B. :|
|In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.). Transgenic Res , 2023. Pubmed reference: 37733197. DOI: 10.1007/s11248-023-00368-4.|
- Created by Imke Tammen2 on 23 Sep 2023