OMIA:002628-8030 : Skin colour, albinism, oculocutaneous type IV in Salmo salar (Atlantic salmon)

In other species: northern snakehead , redhead cichlid , royal farlowella

Categories: Pigmentation phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606574 (trait) , 606202 (gene)

Mendelian trait/disorder: yes

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: Raudstein et al. (2023) microinjected salmon embryos with LbCas12a ribonucleoprotein complexes targeting the pigmentation gene solute carrier family 45 member 2 (slc45a2). Using CRISPR/LbCas12a, [the authors] were able to knock-out slc45a2 and knock-in a FLAG sequence element by providing single-stranded DNA templates." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
slc45a2 solute carrier family 45, member 2 Salmo salar ssa01 NC_059442.1 (131423988..131398604) slc45a2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002628-8030: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 Raudstein, M., Kjærner-Semb, E., Barvik, M., Broll, S., Straume, A.H., Edvardsen, R.B. :
In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.). Transgenic Res , 2023. Pubmed reference: 37733197. DOI: 10.1007/s11248-023-00368-4.

Edit History


  • Created by Imke Tammen2 on 23 Sep 2023
  • Changed by Imke Tammen2 on 18 Dec 2023