OMIA:002628-215402 : Skin colour, albinism, oculocutaneous type IV in Channa argus (northern snakehead) |
In other species: Atlantic salmon , redhead cichlid , royal farlowella
Categories: Pigmentation phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606574 (trait) , 606202 (gene)
Single-gene trait/disorder: yes
Mode of inheritance: Autosomal recessive
Disease-related: no
Key variant known: yes
Year key variant first reported: 2023
Species-specific name: yellow skin, yellow-mutant
Species-specific symbol: YM
Species-specific description: Sun et al. (2023): "During the breeding of C. argus, three varieties with distinct colour morphs have been discovered in Chinese aquaculture industry, including the wild-type (WT) with greyish-black body colour .... , the widely reported white-albino strain with stable inheritance of the white skin [Zhou et al. 2020, see OMIA:002437-215402] and the newly discovered strain with the golden yellow skin ... ."
Molecular basis: Sun et al. (2023): "By applying genomic analysis approaches, in combination with gene knockdown and rescue experiments, we suggested a non-sense mutation in slc45a2 (c.383G > A) is the causation for the YM [yellow skin] snakehead."
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
SLC45A2 | Channa argus | 18 | NC_090214.1 (7224828..7207650) | SLC45A2 | Homologene, Ensembl , NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1530 | Skin colour, yellow | SLC45A2 | YM | nonsense (stop-gain) | Naturally occurring variant | 19 | c.383G>A | p.(W128*) | 2023 | 36789536 |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002628-215402: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2023 | Sun, D., Qi, X., Wen, H., Li, C., Li, J., Chen, J., Tao, Z., Zhu, M., Zhang, X., Li, Y. : |
The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus). Open Biol 13:220235, 2023. Pubmed reference: 36789536. DOI: 10.1098/rsob.220235. | |
2020 | Zhou, A., Xie, S., Feng, Y., Sun, D., Liu, S., Sun, Z., Li, M., Zhang, C., Zou, J. : |
Insights into the albinism mechanism for two distinct color morphs of Northern Snakehead, Channa argus through histological and transcriptome analyses. Front Genet 11:830, 2020. Pubmed reference: 33193565. DOI: 10.3389/fgene.2020.00830. |
Edit History
- Created by Imke Tammen2 on 17 Feb 2023
- Changed by Imke Tammen2 on 17 Feb 2023
- Changed by Imke Tammen2 on 25 Mar 2023