OMIA:002641-9615 : Thoracolumbar myelopathy in Canis lupus familiaris (dog)

Categories: Nervous system phene , Muscle phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Pug (Dog) (VBO_0201089).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002641-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Brander, G., Rohdin, C., Bianchi, M., Bergvall, K., Andersson, G., Ljungvall, I., Hultin Jäderlund, K., Häggström, J., Hedhammar, Å., Lindblad-Toh, K., Tengvall, K. :
Multiple genetic loci associated with pug dog thoracolumbar myelopathy. Genes (Basel) 14:385, 2023. Pubmed reference: 36833311. DOI: 10.3390/genes14020385.
2022 O'Neill, D.G., Sahota, J., Brodbelt, D.C., Church, D.B., Packer, R.M.A., Pegram, C. :
Health of Pug dogs in the UK: disorder predispositions and protections. Canine Med Genet 9:4, 2022. Pubmed reference: 35581668. DOI: 10.1186/s40575-022-00117-6.
2020 Lourinho, F., Holdsworth, A., McConnell, J.F., Gonçalves, R., Gutierrez-Quintana, R., Morales, C., Lowrie, M., Trevail, R., Carrera, I. :
Clinical features and MRI characteristics of presumptive constrictive myelopathy in 27 pugs. Vet Radiol Ultrasound 61:545-554, 2020. Pubmed reference: 32583954. DOI: 10.1111/vru.12890.
Rohdin, C., Ljungvall, I., Häggström, J., Leijon, A., Lindblad-Toh, K., Matiasek, K., Rosati, M., Wohlsein, P., Jäderlund, K.H. :
Thoracolumbar meningeal fibrosis in pugs. J Vet Intern Med 34:797-807, 2020. Pubmed reference: 32003496. DOI: 10.1111/jvim.15716.
2019 Alisauskaite, N., Cizinauskas, S., Jeserevics, J., Rakauskas, M., Cherubini, G.B., Anttila, M., Steffen, F. :
Short- and long-term outcome and magnetic resonance imaging findings after surgical treatment of thoracolumbar spinal arachnoid diverticula in 25 Pugs. J Vet Intern Med 33:1376-1383, 2019. Pubmed reference: 30844093. DOI: 10.1111/jvim.15470.
Driver, C.J., Rose, J., Tauro, A., Fernandes, R., Rusbridge, C. :
Magnetic resonance image findings in pug dogs with thoracolumbar myelopathy and concurrent caudal articular process dysplasia. BMC Vet Res 15:182, 2019. Pubmed reference: 31151444. DOI: 10.1186/s12917-019-1866-0.
2018 Rohdin, C., Häggström, J., Ljungvall, I., Nyman Lee, H., De Decker, S., Bertram, S., Lindblad-Toh, K., Hultin Jäderlund, K. :
Presence of thoracic and lumbar vertebral malformations in pugs with and without chronic neurological deficits. Vet J 241:24-30, 2018. Pubmed reference: 30340656. DOI: 10.1016/j.tvjl.2018.09.008.
2013 Fisher, S.C., Shores, A., Simpson, S.T. :
Constrictive myelopathy secondary to hypoplasia or aplasia of the thoracolumbar caudal articular processes in Pugs: 11 cases (1993-2009). J Am Vet Med Assoc 242:223-9, 2013. Pubmed reference: 23276100. DOI: 10.2460/javma.242.2.223.

Edit History

  • Created by Imke Tammen2 on 28 Feb 2023
  • Changed by Imke Tammen2 on 28 Feb 2023