OMIA:002648-9541 : Circadian disruption, BMAL1-related in Macaca fascicularis (crab-eating macaque)

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 602550 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Species-specific description: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
BMAL1 basic helix-loop-helix ARNT like 1 Macaca fascicularis 14 NC_052268.1 (73665169..73746067) BMAL1 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002648-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Yang, Y., Yu, P., Lu, Y., Gao, C., Sun, Q. :
Disturbed rhythmicity of intestinal hydrogen peroxide alters gut microbial oscillations in BMAL1-deficient monkeys. Cell Rep 42:112183, 2023. Pubmed reference: 36857177. DOI: 10.1016/j.celrep.2023.112183.
2019 Liu, Z., Cai, Y., Liao, Z., Xu, Y., Wang, Y., Wang, Z., Jiang, X., Li, Y., Lu, Y., Nie, Y., Zhang, X., Li, C., Bian, X., Poo, M.M., Chang, H.C., Sun, Q. :
Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer. Natl Sci Rev 6:101-108, 2019. Pubmed reference: 34691835. DOI: 10.1093/nsr/nwz003.
Qiu, P., Jiang, J., Liu, Z., Cai, Y., Huang, T., Wang, Y., Liu, Q., Nie, Y., Liu, F., Cheng, J., Li, Q., Tang, Y.C., Poo, M.M., Sun, Q., Chang, H.C. :
BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders. Natl Sci Rev 6:87-100, 2019. Pubmed reference: 34691834. DOI: 10.1093/nsr/nwz002.

Edit History

  • Created by Imke Tammen2 on 09 Mar 2023
  • Changed by Imke Tammen2 on 09 Mar 2023
  • Changed by Imke Tammen2 on 18 Dec 2023