OMIA:002665-9823 : Genetically engineered humanized animal in Sus scrofa (pig) |
In other species: chicken , crab-eating macaque , Rhesus monkey , taurine cattle , goat
Categories: Immune system phene
Mendelian trait/disorder: unknown
Disease-related: no
Species-specific description:
These studies involve genetically modified organisms (GMO) for the use of xenotransplantation or as models of human disease. See reference list for additional examples.
Zhang et al. (2021) "used CRISPR/Cas9 techniques to targeted knock-in three humanized disease risk genes, GIPRdn , hIAPP and PNPLA3I148M . Transgenic effect increased the risk of metabolic disorders."
Flisikowskawe et al. (2022) "report the generation of Göttingen minipigs carrying a mini-repertoire of human genes for the immunoglobulin heavy chains γ1 and γ4 and the immunoglobulin light chain κ."
Anand et al. (2023) "describe the design, creation and long-term life-supporting function of kidney grafts from a genetically engineered porcine donor transplanted into a cynomolgus monkey model. The porcine donor was engineered to carry 69 genomic edits, eliminating glycan antigens, overexpressing human transgenes and inactivating porcine endogenous retroviruses."
Lei et al. (2024) "study engraftment and survival of porcine islet cells expressing human programmed death-ligand 1 (hPD-L1) in a humanized mouse model."
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002665-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Chaban, R., Ileka, I., McGrath, G., Kinoshita, K., Habibabady, Z., Ma, M., Diaz, V., Maenaka, A., Calhoun, A., Dufault, M., Rosales, I., Laguerre, C.M., Sanatkar, S.A., Burdorf, L., Ayares, D.L., Eyestone, W., Sardana, P., Kuravi, K., Sorrells, L., Lederman, S., Lucas, C.G., Prather, R.S., Wells, K.D., Whitworth, K.M., Cooper, D.K., Pierson Iii, R.N. : |
| Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression. J Heart Lung Transplant , 2024. Pubmed reference: 39097214. DOI: 10.1016/j.healun.2024.07.022. | |
| Lei, Y., Wolf-van Buerck, L., Honarpisheh, M., Zhang, Y., Schwinzer, R., Petersen, B., Seissler, J. : | |
| Neonatal islets from human PD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized nonobese diabetic-scid IL2rγ<sup>null</sup> mice. Am J Transplant 24:S1600-6135(23)00664-0:20-29, 2024. Pubmed reference: 37659605. DOI: 10.1016/j.ajt.2023.08.026. | |
| Manook, M., Olaso, D., Anwar, I., DeLaura, I., Yoon, J., Bae, Y., Barbas, A., Shaw, B., Moris, D., Song, M., Farris, A.B., Stiede, K., Youd, M., Knechtle, S., Kwun, J. : | |
| Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig. Sci Transl Med 16:eadk6152, 2024. Pubmed reference: 38865482. DOI: 10.1126/scitranslmed.adk6152. | |
| Miao, J., Zhang, K., Yang, Y., Xu, S., Du, J., Wu, T., Tao, C., Wang, Y., Yang, S. : | |
| Single-nucleus transcriptomics reveal cardiac cell type-specific diversification in metabolic disease transgenic pigs. iScience 27:110015, 2024. Pubmed reference: 38868189. DOI: 10.1016/j.isci.2024.110015. | |
| Peterson, L., Yacoub, M., Ayares, D., Yamada, K., Eisenson, D., Griffith, B.P., Mohiuddin, M., Eyestone, W., Venter, J.C., Smolenski, R.T., Rothblatt, M. : | |
| Physiological basis for xenotransplantation from genetically-modified pigs to humans: A review. Physiol Rev 104:1409-1459, 2024. Pubmed reference: 38517040. DOI: 10.1152/physrev.00041.2023. | |
| Raza, S.S., Hara, H., Eyestone, W., Ayares, D., Cleveland, D.C., Cooper, D.K.C. : | |
| Pigs in transplantation research and their potential as sources of organs in clinical xenotransplantation. Comp Med 74:33-48, 2024. Pubmed reference: 38359908. DOI: 10.30802/AALAS-CM-23-000030. | |
| Roh, J., Hwang, J.H., Park, S., Lee, H., Park, E.M., Lee, H.W., Lee, J.Y., Shim, J., Choi, K., Kang, H.J. : | |
| Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates. Front Immunol 15:1418249, 2024. Pubmed reference: 38994362. DOI: 10.3389/fimmu.2024.1418249. | |
| Schmalkuche, K., Rother, T., Besli, S., Schwinzer, R., Blasczyk, R., Petersen, B., Figueiredo, C. : | |
| Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys. Front Immunol 15:1279050, 2024. Pubmed reference: 38352884. DOI: 10.3389/fimmu.2024.1279050. | |
| Wang, Y., Chen, G., Pan, D., Guo, H., Jiang, H., Wang, J., Feng, H., He, S., Du, J., Zhang, M., Li, T., Wang, Y., Yu, H., Gan, H., Wen, Q., Song, Z., Li, D., Yu, Y., Wang, H., Li, B., You, Y., Zhou, S., Wang, M., Liu, L., Xu, L., Yang, M., Pei, H., Zhang, K., Chen, Z.K. : | |
| Pig-to-human kidney xenotransplants using genetically modified minipigs. Cell Rep Med 5:101744, 2024. Pubmed reference: 39317190. DOI: 10.1016/j.xcrm.2024.101744. | |
| Yang, C., Wei, Y., Li, X., Xu, K., Huo, X., Chen, G., Zhao, H., Wang, J., Wei, T., Qing, Y., Guo, J., Zhao, H., Zhang, X., Jiao, D., Xiong, Z., Jamal, M.A., Zhao, H.Y., Wei, H.J. : | |
| Production of four-gene (GTKO/hCD55/hTBM/hCD39)-edited donor pigs and kidney xenotransplantation. Xenotransplantation 31:e12881, 2024. Pubmed reference: 39185796. DOI: 10.1111/xen.12881. | |
| Yang, Y., Miao, J., Du, J., Xu, S., Zhang, K., Wu, T., Tao, C., Wang, Y., Fang, M., Yang, S. : | |
| Deficiency of SLC26A3 promotes jejunal barrier damage in metabolic disease-susceptible transgenic pigs. Int J Biol Macromol 281:136245, 2024. Pubmed reference: 39368571. DOI: 10.1016/j.ijbiomac.2024.136245. | |
| Yuan, Y., Cui, Y., Zhao, D., Yuan, Y., Zhao, Y., Li, D., Jiang, X., Zhao, G. : | |
| Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage. J Transl Med 22:324, 2024. Pubmed reference: 38566098. DOI: 10.1186/s12967-024-05136-4. | |
| Zhang, B., Ji, P., Peng, L., Zhai, M., Tang, J., Zhao, L., Jin, Y., Xu, B., Lyu, X., Lu, L., Zhou, Y., Jin, Z., Duan, W., Yang, X., Yi, W., Liu, J. : | |
| Clinical treatment procedure and experience of six gene-edited pig-rhesus monkey heterotopic heart xenotransplantation. Chin Med J (Engl) 137:997-999, 2024. Pubmed reference: 38432900. DOI: 10.1097/CM9.0000000000003030. | |
| 2023 | Anand, R.P., Layer, J.V., Heja, D., Hirose, T., Lassiter, G., Firl, D.J., Paragas, V.B., Akkad, A., Chhangawala, S., Colvin, R.B., Ernst, R.J., Esch, N., Getchell, K., Griffin, A.K., Guo, X., Hall, K.C., Hamilton, P., Kalekar, L.A., Kan, Y., Karadagi, A., Li, F., Low, S.C., Matheson, R., Nehring, C., Otsuka, R., Pandelakis, M., Policastro, R.A., Pols, R., Queiroz, L., Rosales, I.A., Serkin, W.T., Stiede, K., Tomosugi, T., Xue, Y., Zentner, G.E., Angeles-Albores, D., Chris Chao, J., Crabtree, J.N., Harken, S., Hinkle, N., Lemos, T., Li, M., Pantano, L., Stevens, D., Subedar, O.D., Tan, X., Yin, S., Anwar, I.J., Aufhauser, D., Capuano, S., Kaufman, D.B., Knechtle, S.J., Kwun, J., Shanmuganayagam, D., Markmann, J.F., Church, G.M., Curtis, M., Kawai, T., Youd, M.E., Qin, W. : |
| Design and testing of a humanized porcine donor for xenotransplantation. Nature 622:393-401, 2023. Pubmed reference: 37821590. DOI: 10.1038/s41586-023-06594-4. | |
| Burdorf, L., Gao, Z., Riner, A., Sievert, E., Harris, D.G., Kuravi, K.V., Morrill, B.H., Habibabady, Z., Rybak, E., Dahi, S., Zhang, T., Schwartz, E., Kang, E., Cheng, X., Esmon, C.T., Phelps, C.J., Ayares, D.L., Iii, R.N.P., Azimzadeh, A.M. : | |
| Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood. Xenotransplantation 30:e12828, 2023. Pubmed reference: 37767640. DOI: 10.1111/xen.12828. | |
| Hosny, N., Rao, J.S., Burlak, C. : | |
| Endoplasmic reticulum stress and cellular homeostasis in genetically engineered porcine donors for xenotransplantation. Exp Clin Transplant 21:387-396, 2023. Pubmed reference: 37334686. DOI: 10.6002/ect.2022.0357. | |
| Moazami, N., Stern, J.M., Khalil, K., Kim, J.I., Narula, N., Mangiola, M., Weldon, E.P., Kagermazova, L., James, L., Lawson, N., Piper, G.L., Sommer, P.M., Reyentovich, A., Bamira, D., Saraon, T., Kadosh, B.S., DiVita, M., Goldberg, R.I., Hussain, S.T., Chan, J., Ngai, J., Jan, T., Ali, N.M., Tatapudi, V.S., Segev, D.L., Bisen, S., Jaffe, I.S., Piegari, B., Kowalski, H., Kokkinaki, M., Monahan, J., Sorrells, L., Burdorf, L., Boeke, J.D., Pass, H., Goparaju, C., Keating, B., Ayares, D., Lorber, M., Griesemer, A., Mehta, S.A., Smith, D.E., Montgomery, R.A. : | |
| Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nat Med 29:1989-1997, 2023. Pubmed reference: 37488288. DOI: 10.1038/s41591-023-02471-9. | |
| Park, S., Lee, H., Park, E.M., Roh, J., Kang, P.I., Shim, J., Choi, K., Kang, H.J. : | |
| Initial investigation on the feasibility of porcine red blood cells from genetically modified pigs as an alternative to human red blood cells for transfusion. Front Immunol 14:1298035, 2023. Pubmed reference: 38035112. DOI: 10.3389/fimmu.2023.1298035. | |
| Salvaris, E.J., Fisicaro, N., McIlfatrick, S., Thomas, A., Fuller, E., Lew, A.M., Nottle, M.B., Hawthorne, W.J., Cowan, P.J. : | |
| Characterisation of transgenic pigs expressing a human T cell-depleting anti-CD2 monoclonal antibody. Xenotransplantation 31:e12836, 2023. Pubmed reference: 37961013. DOI: 10.1111/xen.12836. | |
| Singireddy, S., Tully, A., Galindo, J., Ayares, D., Singh, A.K., Mohiuddin, M.M. : | |
| Genetic Engineering of Donor Pig for the First Human Cardiac Xenotransplantation: Combatting Rejection, Coagulopathy, Inflammation, and Excessive Growth. Curr Cardiol Rep 25:1649-1656, 2023. Pubmed reference: 37938425. DOI: 10.1007/s11886-023-01978-4. | |
| Wolf, E., Reichart, B., Moretti, A., Laugwitz, K.L. : | |
| Designer pigs for xenogeneic heart transplantation and beyond. Dis Model Mech 16:dmm050177, 2023. Pubmed reference: 37249503. DOI: 10.1242/dmm.050177. | |
| 2022 | Flisikowska, T., Egli, J., Flisikowski, K., Stumbaum, M., Küng, E., Ebeling, M., Schmucki, R., Georges, G., Singer, T., Kurome, M., Kessler, B., Zakhartchenko, V., Wolf, E., Weber, F., Schnieke, A., Iglesias, A. : |
| A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies. Nat Biomed Eng 6:1248-1256, 2022. Pubmed reference: 36138193. DOI: 10.1038/s41551-022-00921-2. | |
| 2021 | Zhang, K., Tao, C., Xu, J., Ruan, J., Xia, J., Zhu, W., Xin, L., Ye, H., Xie, N., Xia, B., Li, C., Wu, T., Wang, Y., Schroyen, M., Xiao, X., Fan, J., Yang, S. : |
| CD8+ T cells involved in metabolic inflammation in visceral adipose tissue and liver of transgenic pigs. Front Immunol 12:690069, 2021. Pubmed reference: 34322121. DOI: 10.3389/fimmu.2021.690069. |
Edit History
- Created by Imke Tammen2 on 21 Apr 2023
- Changed by Imke Tammen2 on 21 Apr 2023
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