OMIA:002666-9823 : Muscular hypertrophy, TRIM63-related in Sus scrofa (pig)

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606131 (gene)

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: Li et al. (2023) "bred F1 generation Murf1+/- and F2 generation Murf1-/- Duroc pigs from F0 Murf1-/- pigs [generated by CRISPR/Cas9 genome editing] to investigate the effect of Murf1 knockout on skeletal muscle development. ... inhibiting muscle protein degradation in MuRF1-deficient Duroc pigs increases the size of their myofibers and their percentage of lean meat without influencing their growth or pork quality." MURF1 is an alternative name for TRIM63. This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Duroc (Pig) (VBO_0001127).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase Sus scrofa 6 NC_010448.4 (83507471..83493200) TRIM63 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002666-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 Li, J., Hu, Y., Li, J., Wang, H., Wu, H., Zhao, C., Tan, T., Zhang, L., Zhu, D., Liu, X., Li, N., Hu, X. :
Loss of MuRF1 in Duroc pigs promotes skeletal muscle hypertrophy. Transgenic Res 32:153-167, 2023. Pubmed reference: 37071377. DOI: 10.1007/s11248-023-00342-0.

Edit History

  • Created by Imke Tammen2 on 21 Apr 2023
  • Changed by Imke Tammen2 on 18 Dec 2023