OMIA:002666-9823 : Muscular hypertrophy, TRIM63-related in Sus scrofa (pig) |
Categories: Muscle phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 606131 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2023
Species-specific description: Li et al. (2023) "bred F1 generation Murf1+/- and F2 generation Murf1-/- Duroc pigs from F0 Murf1-/- pigs [generated by CRISPR/Cas9 genome editing] to investigate the effect of Murf1 knockout on skeletal muscle development. ... inhibiting muscle protein degradation in MuRF1-deficient Duroc pigs increases the size of their myofibers and their percentage of lean meat without influencing their growth or pork quality." MURF1 is an alternative name for TRIM63. This study involves genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TRIM63 | tripartite motif containing 63, E3 ubiquitin protein ligase | Sus scrofa | 6 | NC_010448.4 (83507471..83493200) | TRIM63 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002666-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2023 | Li, J., Hu, Y., Li, J., Wang, H., Wu, H., Zhao, C., Tan, T., Zhang, L., Zhu, D., Liu, X., Li, N., Hu, X. : |
| Loss of MuRF1 in Duroc pigs promotes skeletal muscle hypertrophy. Transgenic Res :, 2023. Pubmed reference: 37071377 . DOI: 10.1007/s11248-023-00342-0. |
Edit History
- Created by Imke Tammen2 on 21 Apr 2023