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OMIA:002670-9793 : Lactoglobulin, beta in Equus asinus (ass (donkey))

In other species: taurine cattle , indicine cattle (zebu)

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Year key variant first reported: 2023

Species-specific description: Cosenza et al. (2023) "report the whole nucleotide sequence of the BLG I [LOC106829109] gene from 2 donkeys, whose milk samples are characterized by the β-LG I [beta lactoglobulin] SDS-PAGE band with a normal electrophoretic mobility ..., and by the presence of a unique β-LG I band with a higher electrophoretic mobility ... . A high genetic variability was found all over the 2 sequenced BLG I alleles." Based on their sequencing results and publicly available information the authors "deduce at least 5 different alleles (BLG I A, B, B1, C, D) responsible for 4 potential β-LG I translations." PAEP is the HGNC approved gene symbol for beta-lactglobulin (BLG).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
LOC106829109 beta-lactoglobulin-1 Equus asinus 10 NC_052186.1 (8316754..8322198) LOC106829109 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002670-9793: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Cosenza, G., Martin, P., Garro, G., Gallo, D., Auzino, B., Ciampolini, R., Pauciullo, A. :
A novel allelic donkey β-lactogobulin I protein isoform generated by a non-AUG translation initiation codon is associated with a nonsynonymous SNP. J Dairy Sci , 2023. Pubmed reference: 37080792. DOI: 10.3168/jds.2022-22598.
2022 Auzino, B., Miranda, G., Henry, C., Krupova, Z., Martini, M., Salari, F., Cosenza, G., Ciampolini, R., Martin, P. :
Top-Down proteomics based on LC-MS combined with cDNA sequencing to characterize multiple proteoforms of Amiata donkey milk proteins. Food Res Int 160:111611, 2022. Pubmed reference: 36076434. DOI: 10.1016/j.foodres.2022.111611.
2000 Herrouin, M., Mollé, D., Fauquant, J., Ballestra, F., Maubois, J.L., Léonil, J. :
New genetic variants identified in donkey's milk whey proteins. J Protein Chem 19:105-15, 2000. Pubmed reference: 10945434. DOI: 10.1023/a:1007078415595.
1988 Godovac-Zimmermann, J., Conti, A., James, L., Napolitano, L. :
Microanalysis of the amino-acid sequence of monomeric beta-lactoglobulin I from donkey (Equus asinus) milk. The primary structure and its homology with a superfamily of hydrophobic molecule transporters. Biol Chem Hoppe Seyler 369:171-9, 1988. Pubmed reference: 3370127. DOI: 10.1515/bchm3.1988.369.1.171.

Edit History


  • Created by Imke Tammen2 on 22 Apr 2023
  • Changed by Imke Tammen2 on 22 Apr 2023
  • Changed by Imke Tammen2 on 28 Feb 2024