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OMIA:002674-9823 : sterile, NANOS3-related in Sus scrofa (pig)

In other species: taurine cattle

Categories: Reproductive system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 608229 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Wang et al. (2023) created NANOS3 knockout pigs by somatic cell nuclear transfer and "found that Nanos3 knockout specifically and completely disrupted the development of early germ cells in males and females, and that these cells cannot proceed to become functional sperm and oocytes. ... [The authors] discovered that constitutive Nanos3 knockout specifically blocked germ cell development, but did not alter the overall development, growth and survival of Nanos3−/− pigs." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
NANOS3 nanos homolog 3 (Drosophila) Sus scrofa 2 NC_010444.3 (65552341..65548897) NANOS3 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002674-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 Wang, J., Ren, J., Wang, Q., Li, C., Han, Z., Chen, T., Sun, K., Feng, G., Zhang, Y., Han, J., Zhou, Q., Li, W., Yu, D., Hai, T. :
Nanos3 knockout pigs to model transplantation and reconstruction of the germline. Cell Prolif :e13463, 2023. Pubmed reference: 37094948. DOI: 10.1111/cpr.13463.

Edit History


  • Created by Imke Tammen2 on 26 Apr 2023
  • Changed by Imke Tammen2 on 26 Apr 2023
  • Changed by Imke Tammen2 on 18 Dec 2023