OMIA:002674-9913 : sterile, NANOS3-related in Bos taurus (taurine cattle)

In other species: pig

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 608229 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific name: Mueller et al. (2023) "generated NANOS3 KO [knock-out] cattle via cytoplasmic microinjection of the CRISPR/Cas9 system in vitro produced bovine zygotes and evaluated the effect of NANOS3 elimination on bovine germline development, from fetal development through reproductive age. ... Overall, this study demonstrated that the absence of NANOS3 in cattle leads to the specific deficiency of both male and female germ cells, suggesting the potential of NANOS3 KO cattle to act as hosts for donor-derived exogenous germ cell production in both sexes." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
NANOS3 nanos C2HC-type zinc finger 3 Bos taurus 7 NC_037334.1 (11818761..11807311) NANOS3 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002674-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 Mueller, M.L., McNabb, B.R., Owen, J.R., Hennig, S.L., Ledesma, A.V., Angove, M.L., Conley, A.J., Ross, P.J., Van Eenennaam, A.L. :
Germline ablation achieved via CRISPR/Cas9 targeting of NANOS3 in bovine zygotes. Front Genome Ed 5:1321243, 2023. Pubmed reference: 38089499. DOI: 10.3389/fgeed.2023.1321243.

Edit History

  • Created by Imke Tammen2 on 24 Dec 2023
  • Changed by Imke Tammen2 on 24 Dec 2023