OMIA:002686-8090 : Colour vision, deficiency in Oryzias latipes (Japanese medaka)
Categories: Vision / eye phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 303800 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Cross-species summary: Dichromatic colour vision; colorblindness; colour blind; color vision deficiency; CVD
Molecular basis: Lu et al. (2023) "constructed the sws1 knockout medaka using CRISPR/Cas9 technology. ... results suggest that sws1 deficiency in medaka larvae may impair visual function and cause retinal cell apoptosis ... ." The sws1 gene is also called OPN1SW, and in humans variants in the gene cause blue colour blindness. This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2023||Lu, K., Wu, J., Tang, S., Wang, Y., Zhang, L., Chai, F., Liang, X.F. :|
|Altered visual function in short-wave-sensitive 1 (sws1) gene knockout Japanese medaka (Oryzias latipes) larvae. Cells 12, 2023. Pubmed reference: 37681889. DOI: 10.3390/cells12172157.|
- Created by Imke Tammen2 on 19 Sep 2023
- Changed by Imke Tammen2 on 19 Sep 2023