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OMIA:002687-30538 : Fleece variation (fine vs coarse) in Vicugna pacos (alpaca)

In other species: goat , sheep

Categories: Integument (skin) phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 608248 (gene) , 194300 (trait) , 604095 (gene) , 612630 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: More et al. (2023) aimed to identify "candidate genomic regions associated with fiber diameter in [Huacaya] alpacas. ... Four candidate regions with adjacent SNPs identified via two association methods of analysis are located on VPA6, VPA9, VPA29 and one chromosomally unassigned scaffold."

Tan et al. (2023) mapped differences in Suri and Huacaya fleece type to "chromosome 16 (NW_021964192.1), which contains a cluster of keratin genes. A haplotype predominantly found in Suri alpacas has been identified which supports dominant inheritance. Variant filtering of nine whole-genome sequenced alpacas from both fleece types in the critical interval of 0.4 Mb did not reveal perfect segregation of either fleece type for specific variants."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Huacaya (Alpaca) (VBO_0000039), Suri (Alpaca) (VBO_0000040).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002687-30538: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Gutiérrez, J.P., Cruz, A., Morante, R., Burgos, A., Formoso-Rafferty, N., Cervantes, I. :
Genetic parameters for fleece uniformity in Alpacas. J Anim Sci , 2023. Pubmed reference: 37144830. DOI: 10.1093/jas/skad140.
More, M., Veli, E., Cruz, A., Gutiérrez, J.P., Gutiérrez, G., Ponce de León, F.A. :
Genome-wide association study of fiber diameter in alpacas. Animals (Basel) 13, 2023. Pubmed reference: 37958071. DOI: 10.3390/ani13213316.
Tan, K., Adeniyi, O.O., Letko, A., RuddGarces, G., Manz, E., Wagner, H., Zanolari, P., Drögemüller, C., Lühken, G. :
Identification of genomic regions associated with differences in fleece type in Huacaya and Suri alpacas (Vicugna pacos). Anim Genet , 2023. Pubmed reference: 37985006. DOI: 10.1111/age.13377.

Edit History


  • Created by Imke Tammen2 on 07 May 2023
  • Changed by Imke Tammen2 on 16 Oct 2023
  • Changed by Imke Tammen2 on 22 Nov 2023