OMIA:002712-9031 : Biopharming, IgG1-related in Gallus gallus (chicken) |
Categories: Immune system phene
Mendelian trait/disorder: unknown
Disease-related: no
Species-specific description: Park et al. (2023) "generated genome-edited chickens that synthesize human IgG1 Fc in the liver and secrete α-2,6 sialylated and low-fucosylated human IgG1 Fc (rhIgG1 Fc) into serum and egg yolk." This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002712-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2023 | Park, J.S., Choi, H.J., Jung, K.M., Lee, K.Y., Shim, J.H., Park, K.J., Kim, Y.M., Han, J.Y. : |
| Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens. Commun Biol 6:589, 2023. Pubmed reference: 37264071. DOI: 10.1038/s42003-023-04937-5. |
Edit History
- Created by Imke Tammen2 on 04 Jun 2023
- Changed by Imke Tammen2 on 04 Jun 2023
- Changed by Imke Tammen2 on 18 Dec 2023