OMIA:002733-7998 : Omega-3 fatty acid content, increased in Ictalurus punctatus (channel catfish)

Categories: Homeostasis / metabolism phene

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: Coogan et al. (2023) used CRISPR/Cas9 technology to 'knock in' a masu salmon elongase gene into the channel catfish melanocortin-4 receptor (mc4r) gene site: "To our knowledge this is the first example of genome engineering to simultaneously target transgenesis and knock-out a gene in a commercially important aquaculture species for multiple improved performance traits. With a high transgene integration rate, improved growth, and higher omega-3 fatty acid content, the use of ... transgenic channel catfish appears beneficial for application on commercial farms." (GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002733-7998: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 Coogan, M., Xing, D., Su, B., Alston, V., Johnson, A., Khan, M., Khalil, K., Elaswad, A., Li, S., Wang, J., Lu, C., Wang, W., Hettiarachchi, D., Shang, M., Hasin, T., Qin, Z., Cone, R., Butts, I.A.E., Dunham, R.A. :
CRISPR/Cas9-mediated knock-in of masu salmon (Oncorhyncus masou) elongase gene in the melanocortin-4 (mc4r) coding region of channel catfish (Ictalurus punctatus) genome. Transgenic Res 32:251-264, 2023. Pubmed reference: 37468714. DOI: 10.1007/s11248-023-00346-w.

Edit History


  • Created by Imke Tammen2 on 21 Jul 2023
  • Changed by Imke Tammen2 on 21 Jul 2023
  • Changed by Imke Tammen2 on 18 Dec 2023