OMIA:002767-7957 : Fins, double caudal in Carassius auratus (goldfish) |
Categories: Limbs / fins / digit / tail phene
Mendelian trait/disorder: yes
Mode of inheritance: Recessive
Disease-related: unknown
Key variant known: yes
Year key variant first reported: 2014
Cross-species summary: Twin-tail
Molecular basis: Abe et al. (2014) "show that the bifurcated caudal skeleton arises from a mutation in the chordin gene, which affects embryonic dorsal-ventral (DV) patterning. [The authors] demonstrate that formation of the bifurcated caudal axial skeleton requires a stop-codon mutation in one of two recently duplicated chordin genes."
Genetic engineering:
Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| chordinA | Carassius auratus | - | no genomic information (-..-) | chordinA | Ensembl |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1691 | Twin-tail | chordinA | nonsense (stop-gain) | Naturally occurring variant | p.(E127*) | 2014 | 24569511 |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002767-7957: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Lee, S.H., Wang, C.Y., Li, I.J., Abe, G., Ota, K.G. : |
| Exploring the origin of a unique mutant allele in twin-tail goldfish using CRISPR/Cas9 mutants. Sci Rep 14:8716, 2024. Pubmed reference: 38622170. DOI: 10.1038/s41598-024-58448-2. | |
| Omori, Y., Burgess, S.M. : | |
| The goldfish genome and its utility for understanding gene regulation and vertebrate body morphology. Methods Mol Biol 2707:335-355, 2024. Pubmed reference: 37668923. DOI: 10.1007/978-1-0716-3401-1_22. | |
| 2019 | Guo, D.D., Sun, Y.W., Cui, W.T., Guo, H.H., Du, S.K., Chen, J., Zou, S.M. : |
| Insertional mutagenesis in ChordinA induced by endogenous ΔTgf2 transposon leads to bifurcation of axial skeletal systems in grass goldfish. Sci Rep 9:4098, 2019. Pubmed reference: 30858477. DOI: 10.1038/s41598-019-40651-1. | |
| Li, I.J., Lee, S.H., Abe, G., Ota, K.G. : | |
| Embryonic and postembryonic development of the ornamental twin-tail goldfish. Dev Dyn 248:251-283, 2019. Pubmed reference: 30687996. DOI: 10.1002/dvdy.15. | |
| 2014 | Abe, G., Lee, S.H., Chang, M., Liu, S.C., Tsai, H.Y., Ota, K.G. : |
| The origin of the bifurcated axial skeletal system in the twin-tail goldfish. Nat Commun 5:3360, 2014. Pubmed reference: 24569511. DOI: 10.1038/ncomms4360. |
Edit History
- Created by Imke Tammen2 on 07 Sep 2023
- Changed by Imke Tammen2 on 06 May 2024