OMIA:002772-9541 : Frontotemporal dementia, MAPT-related in Macaca fascicularis (crab-eating macaque)

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 157140 (gene) , 600274 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: Tu et al. (2023) "established non-human primate models that express mutant human Tau P301L (0N4R P301L) via embryonic lentiviral transduction and stereotaxic brain injection of AAV. [The authors] found that mutant Tau elicited neurodegeneration accompanied by typical features of tauopathy and motor function deficits." This study involves genetically engineered or modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MAPT microtubule associated protein tau Macaca fascicularis 16 NC_088390.1 (67475008..67607303) MAPT Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002772-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 Tu, Z., Yan, S., Han, B., Li, C., Liang, W., Lin, Y., Ding, Y., Wei, H., Wang, L., Xu, H., Ye, J., Li, B., Li, S., Li, X.J. :
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys. Signal Transduct Target Ther 8:358, 2023. Pubmed reference: 37735155. DOI: 10.1038/s41392-023-01601-6.

Edit History

  • Created by Imke Tammen2 on 23 Sep 2023
  • Changed by Imke Tammen2 on 23 Sep 2023
  • Changed by Imke Tammen2 on 18 Dec 2023