Categories: Immune system phene

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: von Heyl et al. (2023): "CRISPR/Cas9 was used to knockout either [alpha/beta] or [gamma/delta] T cells in chickens in order to further analyze the adaptive immune response in poultry. While chickens lacking [gamma/delta] T cells showed no obvious phenotype beside missing [gamma/delta] T cells, birds lacking [alpha/beta] T cells revealed a severe immunophenotype." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing