OMIA:002795-9940 : Claw/hoof colour in Ovis aries (sheep)

Categories: Pigmentation phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 156845 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: Su et al. (2023) "conducted a genome-wide association study (GWAS) analysis using restriction site associated DNA sequencing (RAD-seq) data from 577 Australian White sheep (black hoof color = 283, grey hoof color = 106, amber hoof color = 186) and performed association analysis utilizing the mixed linear model in EMMAX. The results of GWAS demonstrated that a specific single-nucleotide polymorphism (SNP; g. 33097911G>A) in intron 14 of the microphthalmia-associated transcription factor (MITF) gene was significantly associated with the hoof color in AUW sheep (p = 9.40 × 10−36)."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MITF microphthalmia-associated transcription factor Ovis aries 19 NC_056072.1 (31911158..31673697) MITF Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002795-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 Su, P., Wu, H., Huang, Y., Lu, X., Yin, J., Zhang, Q., Lan, X. :
The hoof color of Australian White sheep is associated with genetic variation of the MITF gene. Animals (Basel) 13:, 2023. Pubmed reference: 37893942 . DOI: 10.3390/ani13203218.

Edit History

  • Created by Imke Tammen2 on 05 Nov 2023
  • Changed by Imke Tammen2 on 05 Nov 2023