OMIA:002807-8966 : Drug metabolism, poor, CYP2C19-related in Gyps coprotheres (cape vulture) |
Categories: Homeostasis / metabolism phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 124020 (gene) , 609535 (trait)
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2023
Species-specific name: Diclofenac toxicity
Species-specific description: Oluwasegun Adawaren et al. (2023): "The unintended environmental exposure of vultures to diclofenac has resulted in the deaths of millions of old-world vultures on the Asian subcontinent. ... toxicity has been ... associated with a long half-life of elimination and zero order metabolism ... ."
Molecular basis: Oluwasegun Adawaren et al. (2023) "using whole genome sequencing and de-novo transcriptome alignment, the vulture CYP2C19 open reading frame was identified through Splign analysis. The result sequence analysis revealed the presence of a premature stop codon on open reading frame 7. ... The defect was also conserved across the eight non-related vultures tested. From these results, [the authors] conclude that the sensitivity of the old-world vultures to diclofenac is due to the non-expression of a viable CYP2C19 enzyme system."
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
CYP2C19 | Gyps coprotheres | - | no genomic information (-..-) | CYP2C19 | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002807-8966: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2023 | Adawaren, E.O., Labuschagne, C., Abera, A., Naidoo, V. : |
A premature stop codon in the CYP2C19 gene may explain the unexpected sensitivity of vultures to diclofenac toxicity. Toxicol Appl Pharmacol 482:116771, 2023. Pubmed reference: 38013149. DOI: 10.1016/j.taap.2023.116771. |
Edit History
- Created by Imke Tammen2 on 29 Nov 2023