OMIA:002815-8090 : NPY2R deficiency in Oryzias latipes (Japanese medaka)

Categories: Behaviour / neurological phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 162642 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: Lu et al. (2023) "used the CRISPR/Cas9 system to establish npy2r-deficient medaka (Oryzias latipes). ... this is the first npy2r gene knockout model established in fish and demonstrates that npy2r plays an important role in the regulation of reproduction, feeding and anxiety in fish." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
npy2r neuropeptide Y receptor Y2 Oryzias latipes 1 NC_019859.2 (20772038..20769428) npy2r Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002815-8090: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 Lu, K., Jia, X., Wu, J., Wang, Q., Liang, X.F. :
Neuropeptide Y receptor Y2 (npy2r) deficiency reduces anxiety and increases food intake in Japanese medaka (Oryzias latipes). Front Cell Dev Biol 11:1273006, 2023. Pubmed reference: 38020893. DOI: 10.3389/fcell.2023.1273006.

Edit History

  • Created by Imke Tammen2 on 17 Jan 2024