OMIA:002817-516951 : Skin colour, TYRP1-related in Phrynocephalus putjatai (toad-headed agama)

Categories: Pigmentation phene , Integument (skin) phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 115501 (gene) , 612271 (trait)

Mendelian trait/disorder: unknown

Considered a defect: no

Molecular basis: Sun et al. (2024) " studied adjacent populations of the species of toad-headed agama, Phrynocephalus putjatai, distributed in two distinct habitats on Qinghai-Tibet Plateau (QTP) - alpine meadows and sand dunes - with two distinct phenotypes (dark vs. light) in dorsal coloration. ... by genome resequencing analysis, we detected a novel mutation in Tyrp1 that underpinned this color adaptation. The allele frequencies at the site of SNP 459# in the gene of Tyrp1 are 22.22% G/C and 77.78% C/C in dark lizards and 100% G/G in light lizards."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TYRP1 Phrynocephalus putjatai - no genomic information (-..-) TYRP1 Ensembl

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002817-516951: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2024 Sun, B.J., Li, W.M., Lv, P., Wen, G.N., Wu, D.Y., Tao, S.A., Liao, M.L., Yu, C.Q., Jiang, Z.W., Wang, Y., Xie, H.X., Wang, X.F., Chen, Z.Q., Liu, F., Du, W.G. :
Genetically encoded lizard color divergence for camouflage and thermoregulation. Mol Biol Evol 41:msae009, 2024. Pubmed reference: 38243850. DOI: 10.1093/molbev/msae009.

Edit History


  • Created by Imke Tammen2 on 22 Jan 2024
  • Changed by Imke Tammen2 on 22 Jan 2024