OMIA:002856-9823 : Immunoglobulin heavy chain deficiency in Sus scrofa (pig) |
Categories: Immune system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 147100 (gene)
Mendelian trait/disorder: unknown
Disease-related: unknown
Species-specific description: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Molecular basis: Yugo et al. (2018) " successfully generated immunoglobulin heavy chain JH−/− knockout gnotobiotic pigs using CRISPR/Cas9 technology, established a novel JH−/− knockout and wild-type gnotobiotic pig model for [Hepatitis E virus] ... .
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| LOC396781 | IgG heavy chain | Sus scrofa | NW_018084979.1 (3841291..3676148) | LOC396781 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002856-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Redel, B.K., Yoon, J., Reese, E., An, H., Uh, K., Chen, P.R., Prather, R.S., Lee, K. : |
| Novel off-targeting events identified after genome wide analysis of CRISPR-Cas edited pigs. CRISPR J 7:141-149, 2024. Pubmed reference: 38770737. DOI: 10.1089/crispr.2024.0012. | |
| 2019 | Carey, K., Ryu, J., Uh, K., Lengi, A.J., Clark-Deener, S., Corl, B.A., Lee, K. : |
| Frequency of off-targeting in genome edited pigs produced via direct injection of the CRISPR/Cas9 system into developing embryos. BMC Biotechnol 19:25, 2019. Pubmed reference: 31060546. DOI: 10.1186/s12896-019-0517-7. | |
| 2018 | Yugo, D.M., Heffron, C.L., Ryu, J., Uh, K., Subramaniam, S., Matzinger, S.R., Overend, C., Cao, D., Kenney, S.P., Sooryanarain, H., Cecere, T., LeRoith, T., Yuan, L., Jue, N., Clark-Deener, S., Lee, K., Meng, X.J. : |
| Infection dynamics of hepatitis E virus in wild-type and immunoglobulin heavy chain knockout J H-/- gnotobiotic piglets. J Virol 92:e01208-18, 2018. Pubmed reference: 30111571. DOI: 10.1128/JVI.01208-18. |
Edit History
- Created by Imke Tammen2 on 22 May 2024
- Changed by Imke Tammen2 on 22 May 2024