Gene IGF2 : insulin-like growth factor 2 in Sus scrofa |
See the equivalent entry at NCBI |
In other species:
taurine cattle
Symbol:
IGF2
Synonyms: IGF-II
Description:
insulin-like growth factor 2
Type of gene:
protein-coding
Comment:
In adjacent papers in the same journal, Nezer et al. (1999) and Jeon et al. (1999) reported that an imprinted QTL for muscle mass, fat deposition and heart size maps to the IGF2 gene. A few years later, Van Laere et al. (2003) identified the quantitative trait nucleotide (QTN) responsible for this QTL, namely "a nucleotide substitution in intron 3 of IGF2 [IGF2-intron3-3072G>A]. The mutation occurs in an evolutionarily conserved CpG island that is hypomethylated in skeletal muscle. The mutation abrogates in vitro interaction with a nuclear factor, probably a repressor, and pigs inheriting the mutation from their sire have a threefold increase in IGF2 messenger RNA expression in postnatal muscle. Our study establishes a causal relationship between a single-base-pair substitution in a non-coding region and a QTL effect." This was the first-ever such discovery (of a non-coding QTN) in any species!
NCBI gene id:
396916
Other designations:
insulin-like growth factor II|insulin-like growth factor 2 (somatomedin A)|preptin
Links:
Homologene
, Ensembl
Genomic location:
2:1496417..1469183 [Chromosome accession
NC_010444.4]
Related phenes:
OMIA:002467-9823 : Muscle growth, IGF2-related in
Sus scrofa
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2012 | Aslan, O., Hamill, R.M., Davey, G., McBryan, J., Mullen, A.M., Gispert, M., Sweeney, T. : |
| Variation in the IGF2 gene promoter region is associated with intramuscular fat content in porcine skeletal muscle. Mol Biol Rep 39:4101-10, 2012. Pubmed reference: 21779802. DOI: 10.1007/s11033-011-1192-5. | |
| Burgos, C., Galve, A., Moreno, C., Altarriba, J., Reina, R., García, C., López-Buesa, P. : | |
| The effects of two alleles of IGF2 on fat content in pig carcasses and pork. Meat Sci 90:309-13, 2012. Pubmed reference: 21907500. DOI: 10.1016/j.meatsci.2011.07.016. | |
| Rohrer, G.A., Nonneman, D.J., Miller, R.K., Zerby, H., Moeller, S.J. : | |
| Association of single nucleotide polymorphism (SNP) markers in candidate genes and QTL regions with pork quality traits in commercial pigs. Meat Sci 92:511-8, 2012. Pubmed reference: 22688438. DOI: 10.1016/j.meatsci.2012.05.020. | |
| 2011 | Boysen, T.J., Tetens, J., Thaller, G. : |
| Evidence for additional functional genetic variation within the porcine IGF2 gene affecting body composition traits in an experimental Piétrain × Large White/Landrace cross. Animal 5:672-7, 2011. Pubmed reference: 22439990. DOI: 10.1017/S1751731110002466. | |
| Braunschweig, M.H., Owczarek-Lipska, M., Stahlberger-Saitbekova, N. : | |
| Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2. BMC Genet 12:47, 2011. Pubmed reference: 21575277. DOI: 10.1186/1471-2156-12-47. | |
| Fan, B., Onteru, S.K., Du, Z.Q., Garrick, D.J., Stalder, K.J., Rothschild, M.F. : | |
| Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs. PLoS One 6:e14726, 2011. Pubmed reference: 21383979. DOI: 10.1371/journal.pone.0014726. | |
| 2010 | Andersson, L., Andersson, G., Hjälm, G., Jiang, L., Lindblad-Toh, K., Lindroth, A.M., Markljung, E., Nyström, A.M., Rubin, C.J., Sundström, E. : |
| ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals. Transcription 1:144-148, 2010. Pubmed reference: 21326889. DOI: 10.4161/trns.1.3.13343. | |
| Butter, F., Kappei, D., Buchholz, F., Vermeulen, M., Mann, M. : | |
| A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth. EMBO Rep 11:305-11, 2010. Pubmed reference: 20134481. DOI: 10.1038/embor.2010.6. | |
| Fontanesi, L., Speroni, C., Buttazzoni, L., Scotti, E., Dall'Olio, S., Nanni Costa, L., Davoli, R., Russo, V. : | |
| The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism. J Anim Sci 88:2235-45, 2010. Pubmed reference: 20382874. DOI: 10.2527/jas.2009-2560. | |
| Hou, G., Wang, D., Guan, S., Zeng, H., Huang, X., Ma, Y. : | |
| Associated analysis of single nucleotide polymorphisms of IGF2 gene's exon 8 with growth traits in Wuzhishan pig. Mol Biol Rep 37:497-500, 2010. Pubmed reference: 19701694. DOI: 10.1007/s11033-009-9681-5. | |
| Stinckens, A., Mathur, P., Janssens, S., Bruggeman, V., Onagbesan, O.M., Schroyen, M., Spincemaille, G., Decuypere, E., Georges, M., Buys, N. : | |
| Indirect effect of IGF2 intron3 g.3072G>A mutation on prolificacy in sows. Anim Genet 41:493-8, 2010. Pubmed reference: 20394605. DOI: 10.1111/j.1365-2052.2010.02040.x. | |
| 2009 | Andersson, L. : |
| Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin. Cold Spring Harb Symp Quant Biol 74:319-25, 2009. Pubmed reference: 20375320. DOI: 10.1101/sqb.2009.74.039. | |
| Giannini, P., Braunschweig, M. : | |
| DNA methylation patterns at the IGF2-H19 locus in sperm of Swiss Landrace and Swiss Large White boars. J Anim Breed Genet 126:475-9, 2009. Pubmed reference: 19912422. DOI: 10.1111/j.1439-0388.2009.00802.x. | |
| Markljung, E., Jiang, L., Jaffe, J.D., Mikkelsen, T.S., Wallerman, O., Larhammar, M., Zhang, X., Wang, L., Saenz-Vash, V., Gnirke, A., Lindroth, A.M., Barrés, R., Yan, J., Strömberg, S., De, S., Pontén, F., Lander, E.S., Carr, S.A., Zierath, J.R., Kullander, K., Wadelius, C., Lindblad-Toh, K., Andersson, G., Hjälm, G., Andersson, L. : | |
| ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biol 7:e1000256, 2009. Pubmed reference: 20016685. DOI: 10.1371/journal.pbio.1000256. | |
| Oczkowicz, M., Tyra, M., Walinowicz, K., Rózycki, M., Rejduch, B. : | |
| Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds. J Appl Genet 50:257-9, 2009. Pubmed reference: 19638682. DOI: 10.1007/BF03195681. | |
| 2008 | Han, D.W., Im, Y.B., Do, J.T., Gupta, M.K., Uhm, S.J., Kim, J.H., Schöler, H.R., Lee, H.T. : |
| Methylation status of putative differentially methylated regions of porcine IGF2 and H19. Mol Reprod Dev 75:777-84, 2008. Pubmed reference: 18247333. DOI: 10.1002/mrd.20802. | |
| Li, C., Bin, Y., Curchoe, C., Yang, L., Feng, D., Jiang, Q., O'Neill, M., Tian, X.C., Zhang, S. : | |
| Genetic imprinting of H19 and IGF2 in domestic pigs (Sus scrofa). Anim Biotechnol 19:22-7, 2008. Pubmed reference: 18228173. DOI: 10.1080/10495390701758563. | |
| Ojeda, A., Huang, L.S., Ren, J., Angiolillo, A., Cho, I.C., Soto, H., Lemús-Flores, C., Makuza, S.M., Folch, J.M., Pérez-Enciso, M. : | |
| Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2. Genetics 178:1639-52, 2008. Pubmed reference: 18245828. DOI: 10.1534/genetics.107.084269. | |
| Xue, H.L., Xu, L.X. : | |
| [Genetic polymorphisms and genetic effects of IGF2 gene in pigs]. Yi Chuan 30:179-84, 2008. Pubmed reference: 18244923. | |
| Yu, D.B., He, Z.L., Zhang, W.F., Jia, X.X., Qiu, X.S., Wang, L.Y., Huang, R.H., Liu, H.L. : | |
| [The genetic effects of IGF2 gene intron3 variance in pigs]. Yi Chuan 30:87-93, 2008. Pubmed reference: 18244908. DOI: 10.3724/sp.j.1005.2008.00087. | |
| 2007 | Chang, H.P., Ou, J.T., Zhong, J.C., Wang, X.L., Guo, C.H., Bin, S.Y., Ma, Z.J. : |
| [Single nucleotide polymorphism analysis on the 5' regulatory region of IGF2 gene in Wuzhishan pig]. Yi Chuan 29:57-64, 2007. Pubmed reference: 17284425. DOI: 10.1360/yc-007-0057. | |
| Ron, M., Weller, J.I. : | |
| From QTL to QTN identification in livestock--winning by points rather than knock-out: a review. Anim Genet 38:429-39, 2007. Pubmed reference: 17697134. DOI: 10.1111/j.1365-2052.2007.01640.x. | |
| Stinckens, A., Van den Maagdenberg, K., Luyten, T., Georges, M., De Smet, S., Buys, N. : | |
| The RYR1 g.1843C>T mutation is associated with the effect of the IGF2 intron3-g.3072G>A mutation on muscle hypertrophy. Anim Genet 38:67-71, 2007. Pubmed reference: 17257191. DOI: 10.1111/j.1365-2052.2006.01558.x. | |
| 2006 | Vykoukalová, Z., Knoll, A., Dvorák, J., Cepica, S. : |
| New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs. J Anim Breed Genet 123:204-7, 2006. Pubmed reference: 16706926. DOI: 10.1111/j.1439-0388.2006.00580.x. | |
| Yang, G.C., Ren, J., Guo, Y.M., Ding, N.S., Chen, C.Y., Huang, L.S. : | |
| Genetic evidence for the origin of an IGF2 quantitative trait nucleotide in Chinese pigs. Anim Genet 37:179-80, 2006. Pubmed reference: 16573535. DOI: 10.1111/j.1365-2052.2006.01416.x. | |
| 2005 | Carrodeguas, J.A., Burgos, C., Moreno, C., Sánchez, A.C., Ventanas, S., Tarrafeta, L., Barcelona, J.A., López, M.O., Oria, R., López-Buesa, P. : |
| Incidence in diverse pig populations of an IGF2 mutation with potential influence on meat quality and quantity: An assay based on real time PCR (RT-PCR). Meat Sci 71:577-82, 2005. Pubmed reference: 22060936. DOI: 10.1016/j.meatsci.2005.05.002. | |
| Estellé, J., Mercadé, A., Noguera, J.L., Pérez-Enciso, M., Ovilo, C., Sánchez, A., Folch, J.M. : | |
| Effect of the porcine IGF2-intron3-G3072A substitution in an outbred Large White population and in an Iberian x Landrace cross. J Anim Sci 83:2723-8, 2005. Pubmed reference: 16282609. DOI: 10.2527/2005.83122723x. | |
| 2004 | Braunschweig, M.H., Van Laere, A.S., Buys, N., Andersson, L., Andersson, G. : |
| IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3. Genomics 84:1021-9, 2004. Pubmed reference: 15533719. DOI: 10.1016/j.ygeno.2004.09.006. | |
| Jungerius, B.J., van Laere, A.S., Te Pas, M.F., van Oost, B.A., Andersson, L., Groenen, M.A. : | |
| The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross. Genet Res 84:95-101, 2004. Pubmed reference: 15678747. DOI: 10.1017/s0016672304007098. | |
| 2003 | Nezer, C., Collette, C., Moreau, L., Brouwers, B., Kim, J.J., Giuffra, E., Buys, N., Andersson, L., Georges, M. : |
| Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene. Genetics 165:277-85, 2003. Pubmed reference: 14504235. DOI: 10.1093/genetics/165.1.277. | |
| Van Laere, A.S., Nguyen, M., Braunschweig, M., Nezer, C., Collette, C., Moreau, L., Archibald, A.L., Haley, C.S., Buys, N., Tally, M., Andersson, G., Georges, M., Andersson, L. : | |
| A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832-6, 2003. Pubmed reference: 14574411. DOI: 10.1038/nature02064. | |
| 2002 | Amarger, V., Nguyen, M., Van Laere, A.S., Braunschweig, M., Nezer, C., Georges, M., Andersson, L. : |
| Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs. Mamm Genome 13:388-98, 2002. Pubmed reference: 12140686. DOI: 10.1007/s00335-001-3059-x. | |
| 2000 | Knoll, A., Putnová, L., Dvorák, J., Cepica, S. : |
| A NciI PCR-RFLP within intron 2 of the porcine insulin-like growth factor 2 (IGF2) gene. Anim Genet 31:150-1, 2000. Pubmed reference: 10782228. DOI: 10.1046/j.1365-2052.2000.00583.x. | |
| 1999 | Jeon, J.T., Carlborg, O., Törnsten, A., Giuffra, E., Amarger, V., Chardon, P., Andersson-Eklund, L., Andersson, K., Hansson, I., Lundström, K., Andersson, L. : |
| A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nat Genet 21:157-8, 1999. Pubmed reference: 9988263. DOI: 10.1038/5938. | |
| Nezer, C., Moreau, L., Brouwers, B., Coppieters, W., Detilleux, J., Hanset, R., Karim, L., Kvasz, A., Leroy, P., Georges, M. : | |
| An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nat Genet 21:155-6, 1999. Pubmed reference: 9988262. DOI: 10.1038/5935. |
Edit History
- Changed by Frank Nicholas on 25 Nov 2012
- Changed by on 20 Sep 2015