Gene MC4R : melanocortin 4 receptor in Sus scrofa

See the equivalent entry at NCBI

Symbol: MC4R

Description: melanocortin 4 receptor

Type of gene: protein-coding

Comment: Kim et al. (2000) physically mapped this locus to chromosome SSC1q22–q27, and linkage-mapped it in the SSC1 linkage group "FGF7-5.6-MEF2A-5.8-MC4R-5.9-SO313-0-S0082". In many of the studies listed below, polymorphisms within this gene are associated with various production traits.

NCBI gene id: 397359

Other designations: melanocortin receptor 4|MC4-R|melanocortin-4 receptor MC4R

Links: Homologene , Ensembl

Genomic location: 1:160772013..160774124 [Chromosome accession NC_010443.5]

Related phenes:

OMIA:002217-9823 : Hyperphagia leading to hepatic steatosis in Sus scrofa


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2013 Cirera, S., Jensen, M.S., Elbrønd, V.S., Moesgaard, S.G., Christoffersen, B.O., Kadarmideen, H.N., Skovgaard, K., Bruun, C.V., Karlskov-Mortensen, P., Jørgensen, C.B., Fredholm, M. :
Expression studies of six human obesity-related genes in seven tissues from divergent pig breeds. Anim Genet , 2013. Pubmed reference: 24033492. DOI: 10.1111/age.12082.
Onteru, S.K., Gorbach, D.M., Young, J.M., Garrick, D.J., Dekkers, J.C., Rothschild, M.F. :
Whole Genome Association Studies of Residual Feed Intake and Related Traits in the Pig. PLoS One 8:e61756, 2013. Pubmed reference: 23840294. DOI: 10.1371/journal.pone.0061756.
2012 Rohrer, G.A., Nonneman, D.J., Miller, R.K., Zerby, H., Moeller, S.J. :
Association of single nucleotide polymorphism (SNP) markers in candidate genes and QTL regions with pork quality traits in commercial pigs. Meat Sci 92:511-8, 2012. Pubmed reference: 22688438. DOI: 10.1016/j.meatsci.2012.05.020.
2011 Fan, B., Onteru, S.K., Du, Z.Q., Garrick, D.J., Stalder, K.J., Rothschild, M.F. :
Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs. PLoS One 6:e14726, 2011. Pubmed reference: 21383979. DOI: 10.1371/journal.pone.0014726.
2010 Fan, B., Lkhagvadorj, S., Cai, W., Young, J., Smith, R.M., Dekkers, J.C., Huff-Lonergan, E., Lonergan, S.M., Rothschild, M.F. :
Identification of genetic markers associated with residual feed intake and meat quality traits in the pig. Meat Sci 84:645-50, 2010. Pubmed reference: 20374837. DOI: 10.1016/j.meatsci.2009.10.025.
2009 Fan, B., Onteru, S.K., Plastow, G.S., Rothschild, M.F. :
Detailed characterization of the porcine MC4R gene in relation to fatness and growth. Anim Genet 40:401-9, 2009. Pubmed reference: 19397528. DOI: 10.1111/j.1365-2052.2009.01853.x.
Schwab, C.R., Mote, B.E., Du, Z.Q., Amoako, R., Baas, T.J., Rothschild, M.F. :
An evaluation of four candidate genes for use in selection programmes aimed at increased intramuscular fat in Duroc swine. J Anim Breed Genet 126:228-36, 2009. Pubmed reference: 19646151. DOI: 10.1111/j.1439-0388.2008.00770.x.
2007 Otto, G., Roehe, R., Looft, H., Thoelking, L., Knap, P.W., Rothschild, M.F., Plastow, G.S., Kalm, E. :
Associations of DNA markers with meat quality traits in pigs with emphasis on drip loss. Meat Sci 75:185-95, 2007. Pubmed reference: 22063649. DOI: 10.1016/j.meatsci.2006.03.022.
2004 Kim, K.S., Reecy, J.M., Hsu, W.H., Anderson, L.L., Rothschild, M.F. :
Functional and phylogenetic analyses of a melanocortin-4 receptor mutation in domestic pigs. Domest Anim Endocrinol 26:75-86, 2004. Pubmed reference: 14732454.
2000 Kim, K.S., Larsen, N., Short, T., Plastow, G., Rothschild, M.F. :
A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome 11:131-5, 2000. Pubmed reference: 10656927.
Kim, K.S., Larsen, N.J., Rothschild, M.F. :
Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene. J Anim Sci 78:791-2, 2000. Pubmed reference: 10764088.

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  • Changed by Frank Nicholas on 22 Aug 2013