OMIA:000117-9031 : Blood group system A in Gallus gallus (chicken)

In other species: turkey , pig , aoudad , taurine cattle , goat , mouflon , sheep

Categories: Haematopoietic system phene

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal co-dominant

Considered a defect: no

Key variant known: no

Key variant is published: no

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars.

Inheritance: Briles et al. (1959) confirmed the existence of four loci (blood group systems), namely A, B, D, and E, with some evidence of tight linkage between A and E.

Mapping: Fulton et al. (2022): "Genome-wide association studies, sequence analysis, and sequence-derived single-nucleotide polymorphism information for known A and/or E system alleles show that the most likely candidate gene for the A blood system is C4BPM gene (complement component 4 binding protein, membrane). Cosegregation of [24] single-nucleotide polymorphism–defined [14] C4BPM haplotypes and blood system A alleles defined by alloantisera provide a link between chicken blood system A and C4BPM."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
C4BPA complement component 4 binding protein, alpha Gallus gallus 26 NC_052557.1 (2722621..2759934) C4BPA Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000117-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Fulton, J.E., Drobik-Czwarno, W., Wolc, A., McCarron, A.M., Lund, A.R., Schmidt, C.J., Taylor, R.L. :
The chicken A and E blood systems arise from genetic variation in and around the regulators of complement activation region. J Immunol 209:1128-1137, 2022. Pubmed reference: 35977798. DOI: 10.4049/jimmunol.2101010.
1997 Kopti, F., Briles, R.W., Briles, W.E. :
Immunogenetics of the A-E alloantigen complex. Poult Sci 76:1688-97, 1997. Pubmed reference: 9438283.
1990 Fulton, J.E., Briles, R.W., Lamont, S.J. :
Monoclonal antibody differentiates chicken A system alloantigens. Anim Genet 21:39-45, 1990. Pubmed reference: 2331078.
Fulton, J.E., Hall, V.J., Lamont, S.J. :
Ontogeny and expression of chicken A blood group antigens. Anim Genet 21:47-57, 1990. Pubmed reference: 2184702.
Fulton, J.E., Briles, W.E., Lamont, S.J. :
Chicken A blood groups system antigens: molecular characteristics and lack of expression on lymphocytes. Anim Genet 21:401-10, 1990. Pubmed reference: 2090011.
1989 Fulton, J.E., Lamont, S.J. :
Monoclonal antibody specific for chicken blood group A antigens. Prog Clin Biol Res 307:213-9, 1989. Pubmed reference: 2678137.
1984 Briles, W.E. :
Early chicken blood group investigations. Immunogenetics 20:217-26, 1984. Pubmed reference: 6088392.
1970 Seet, C.P., Briles, C.O. :
The association of the A, B and E parental blood group system genotypes with fertility and hatchability in chickens. Poult Sci 49:922-6, 1970. Pubmed reference: 5485484.
1959 Briles, C.O., McGibbon, W.H., Irwin, M.R. :
Additional Alleles Affecting Red Blood Cell Antigens in the Chicken. Genetics 44:955-65, 1959. Pubmed reference: 17247871.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 14 Oct 2011
  • Changed by Imke Tammen2 on 05 May 2023