In other species: pig , goat , sheep

Categories: Haematopoietic system phene

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal co-dominant

Disease-related: no

Key variant known: no

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars.

Mapping: Fulton et al. (2024) conducted a GWAS analysis and mapped chicken I blood system to microchromosome 23.

Markers: Fulton et al. (2024) report a panel containing 15 SNPs in RHCE to define the RHCE gene haplotypes.

Molecular basis: Fulton et al. (2024) identified that variation in RHCE is responsible for the chicken I blood system: "We identified 17 unique RHCE haplotypes in the chicken, with six haplotypes corresponding to known I system serological alleles. We also detected deletions in the RHCE gene that encompass more than 6000 bp and that are predicted to remove its last seven exons."

Associated gene: