OMIA:000160-10036 : Cardiomyopathy in Mesocricetus auratus (golden hamster)

In other species: salmonids , chicken , hedgehogs , dog , domestic cat , taurine cattle , goat

Categories: Cardiovascular system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

History: This disorder was first reported in an inbred line of hamsters by Homburger et al. (1962). From this original line (BIO1.50) were originated a line with hypertrophic cardiomyopathy (BIO14.6) and a line with dilated cardiomyopathy (TO-2; see OMIA 000162-10036) (Sakamoto et al., 1997)

Mapping: The disorder was linkage mapped to chromosome 9QA2.1-B1 by Okasaki et al. (1996).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000160-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Bkaily, G., Simon, Y., Abou Abdallah, J., Ouertane, C., Essalhi, A., Khalil, A., Jacques, D. :
Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent. Nutrients 16:946, 2024. Pubmed reference: 38612980. DOI: 10.3390/nu16070946.
2017 Ichihara, S., Suzuki, Y., Chang, J., Kuzuya, K., Inoue, C., Kitamura, Y., Oikawa, S. :
Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy. Sci Rep 7:9243, 2017. Pubmed reference: 28835655. DOI: 10.1038/s41598-017-08546-1.
1997 Carnio, E.C., Jankowski, M., Mukaddamdaher, S., Gorska, I., Antunesrodrigues, J., Gutkowska, J. :
Elevated levels of natriuretic peptides in lungs of hamsters with genetic cardiomyopathy Regulatory Peptides 70:67-73, 1997. Pubmed reference: 9250583.
Sakamoto, A., Ono, K., Abe, M., Jasmin, G., Eki, T., Murakami, Y., Masaki, T., Toyooka, T., Hanaoka, F. :
Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster - an animal model of disrupted dystrophin-associated glycoprotein complex Proceedings of the National Academy of Sciences of the United States of America 94:13873-13878, 1997. Pubmed reference: 9391120.
1996 Chang, Q., Natelson, B.H., Ottenweller, J.E., Conway, R.S. :
The role of stressor intensity in influencing the course of heart disease in cardiomyopathic hamsters Proceedings of the Society for Experimental Biology & Medicine 212:248-255, 1996.
Okazaki, Y., Okuizumi, H., Ohsumi, T., Nomura, O., Takada, S., Kamiya, M., Sasaki, N., Matsuda, Y., Nishimura, M., Tagaya, O., Muramatsu, M., Hayashizaki, Y. :
Genetic linkage map of the syrian hamster and localization of cardiomyopathy locus on chromosome 9QA2.1-B1 using rlgs spot-mapping Nature Genetics 13:87-90, 1996. Pubmed reference: 8673110. DOI: 10.1038/ng0596-87.
1973 Gertz, E.W. :
Animal model of human disease. Myocardial failure, muscular dystrophy. Am J Pathol 70:151-4, 1973. Pubmed reference: 4682837.
1969 Bajusz, E. :
Hereditary cardiomyopathy: a new disease model American Heart Journal 77:686 only, 1969.
1966 Homburger, F., Nixon, C.W., Eppenberger, M, Baker, J.R. :
Hereditary cardiomyopathy in the Syrian hamster: studies on pathogenesis Annals of the New York Academy of Sciences 138:14 only, 1966.
1963 Homburger, F.M., Harrop, J., Baker, J.R., Wilgram, G., Nixon, C.W. :
Further morphologic and genetic studies on dystrophy-like primary myopathy of Syrian hamsters. Federation Proceedings 22:195 only, 1963.
1962 Homburger, F., Baker, J.R., Nixon, C.W., Whitney, R. :
Primary, generalized polymyopathy and cardiac necrosis in an inbred line of Syrian hamsters. Med. Exp. 6:339-345, 1962.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 05 Aug 2013
  • Changed by Frank Nicholas on 26 Feb 2014
  • Changed by Imke Tammen2 on 14 Apr 2024