Categories: Haematopoietic system phene

Possible human homologues (MIM numbers): 214500 (trait) , 606897 (gene)

Links to relevant human diseases in MONDO:

• MONDO:0008963: Chediak-Higashi syndrome

Cross-species summary: The mouse homologue of this disorder is the beige coat-colour mutation, which is a mutation in the gene for lysosomal trafficking regulator, Lyst. As its name suggests, this gene is involved in lysosomal functioning - lysosomes being the digestive system of the cell. Thus Chediak-Higashi syndrome is a lysosomal disorder.

Species in which this phene is found:
domestic cat (Felis catus)
killer whale (Orcinus orca)
taurine cattle (Bos taurus)
American mink (Neovison vison)
Arctic fox (Vulpes lagopus)