OMIA:000185-9733 : Chediak-Higashi syndrome in Orcinus orca (killer whale)

In other species: domestic cat , taurine cattle , American mink , Arctic fox

Categories: Haematopoietic system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 214500 (trait) , 606897 (gene)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: The mouse homologue of this disorder is the beige coat-colour mutation, which is a mutation in the gene for lysosomal trafficking regulator, Lyst. As its name suggests, this gene is involved in lysosomal functioning - lysosomes being the digestive system of the cell. Thus Chediak-Higashi syndrome is a lysosomal disorder.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000185-9733: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1979 Ridgway, S.H. :
Reported causes of death of captive killer whales (Orcinus orca). J Wildl Dis 15:99-104, 1979. Pubmed reference: 459051.
1973 Taylor, R.F., Farrell, R.K. :
Light and electron microscopy of peripheral blood neutrophils in a killer whale affected with Chediak-Higashi syndrome Federation Proceedings 32:822-, 1973.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005