OMIA:000185-9733 : Chediak-Higashi syndrome in Orcinus orca

In other species: domestic cat , cattle , Arctic fox , American mink

Categories: Haematopoietic system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 214500 (trait) , 606897 (gene)

Links to MONDO diseases:

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: The mouse homologue of this disorder is the beige coat-colour mutation, which is a mutation in the gene for lysosomal trafficking regulator, Lyst. As its name suggests, this gene is involved in lysosomal functioning - lysosomes being the digestive system of the cell. Thus Chediak-Higashi syndrome is a lysosomal disorder.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1979 Ridgway, S.H. :
Reported causes of death of captive killer whales (Orcinus orca). J Wildl Dis 15:99-104, 1979. Pubmed reference: 459051 .
1973 Taylor, R.F., Farrell, R.K. :
Light and electron microscopy of peripheral blood neutrophils in a killer whale affected with Chediak-Higashi syndrome Federation Proceedings 32:822-, 1973.

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  • Created by Frank Nicholas on 06 Sep 2005