OMIA 000185-9733 : Chediak-Higashi syndrome in Orcinus orca
In other species: domestic cat , cattle , Arctic fox , American mink Possibly relevant human trait(s) and/or gene(s) (MIM number): 214500 Mendelian trait/disorder: unknown Considered a defect: yes Cross-species summary: The mouse homologue of this disorder is the beige coat-colour mutation, which is a mutation in the gene for lysosomal trafficking regulator, Lyst. As its name suggests, this gene is involved in lysosomal functioning - lysosomes being the digestive system of the cell. Thus Chediak-Higashi syndrome is a lysosomal disorder.
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1979||Ridgway, S.H. :|
|Reported causes of death of captive killer whales (Orcinus orca). J Wildl Dis 15:99-104, 1979. Pubmed reference: 459051.|
|1973||Taylor, R.F., Farrell, R.K. :|
|Light and electron microscopy of peripheral blood neutrophils in a killer whale affected with Chediak-Higashi syndrome Federation Proceedings 32:822-, 1973.|
- Created by Frank Nicholas on 06 Sep 2005