OMIA 000185-9733 : Chediak-Higashi syndrome in Orcinus orca |
In other species:
domestic cat
,
cattle
,
Arctic fox
,
American mink
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
214500 (trait)
,
606897 (gene)
Mendelian trait/disorder:
unknown
Considered a defect:
yes
Cross-species summary:
The mouse homologue of this disorder is the beige coat-colour mutation, which is a mutation in the gene for lysosomal trafficking regulator, Lyst. As its name suggests, this gene is involved in lysosomal functioning - lysosomes being the digestive system of the cell. Thus Chediak-Higashi syndrome is a lysosomal disorder.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 1979 | Ridgway, S.H. : | |
| Reported causes of death of captive killer whales (Orcinus orca). J Wildl Dis 15:99-104, 1979. Pubmed reference: 459051. | ||
| 1973 | Taylor, R.F., Farrell, R.K. : | |
| Light and electron microscopy of peripheral blood neutrophils in a killer whale affected with Chediak-Higashi syndrome Federation Proceedings 32:822-, 1973. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005