OMIA 000237-9823 : Cranioschisis in Sus scrofa

In other species: dog , cattle , sheep

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A cleft in the skull involving one or more of the bones of the cranial cavity. If meninges (the membranes covering the brain) protrude through the cleft, the disorder is called meningocele. If meninges and brain tissue protrudes, it is called encephalocele or meningo-encephalocele. Since these terms are often used interchangably, all categories have been combined into this one entry.

Inheritance: The most definitive inheritance studies in pigs, by Wijeratne et al. (1974) and Vogt et al. (1986), showed that the disorder is familial, but is not due to a single gene.

Prevalence: Vogt et al. (1986) presented extensive incidence data, showing differences between breeds and between years, with an overall incidence of 0.12% in the University of Missouri-Columbia herd.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1986 Vogt, D.W., Ellersieck, M.R., Deutsch, W.E., Akremi, B., Islam, M.N. :
Congenital meningocele-encephalocele in an experimental swine herd American Journal of Veterinary Research 47:188-191, 1986. Pubmed reference: 3946901.
1974 Wijeratne, W.V.S., Beaton, D., Cuthbertson, J.C. :
A field occurrence of congenital meningoencephalocoele in pigs Veterinary Record 95:81-84, 1974. Pubmed reference: 4439628.
1966 Meyer, H., Trautwein, G. :
[Experimental studies on hereditary meningocele cerebralis in pigs. I. Breeding studies and genetic analysis] Pathologia Veterinaria 3:529-542, 1966. Pubmed reference: 6006166.
Trautwein, G., Meyer, H. :
[Experimental studies on hereditary meningocele cerebralis in pigs. II. Pathology] Pathologia Veterinaria 3:543-555, 1966. Pubmed reference: 6006167.
1965 Labik, K. :
Contribution to the study of the heredity of cranioschisis in piglets Sbornik Vysoke Skoly Zemedelske Brne, Series B 13:313-326, 1965.
1934 Hughes, E.H., Hart, H. :
Defective skulls inherited in swine Journal of Heredity 25:111-115, 1934.
1930 Nordby, J.E. :
Congenital ear and skull defects in swine Journal of Heredity 21:499-501, 1930.
1929 Nordby, J.E. :
Congenital skin, ear, and skull defects in a pig Anatomical Record 42:267-280, 1929.
Nordby, J.E. :
An inherited skull defect in swine. A preliminary report on the inheritance of a fronto-parietal skeletal defect involving the meningocele and proencephalus types of cranioshisis in swine Journal of Heredity 20:228-232, 1929.

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  • Created by Frank Nicholas on 06 Sep 2005