OMIA 000245-9796 : Curly coat in Equus caballus
Thomer et al. (2018) independently discovered the same likely causal variant, but also showed how this variant interacts with a variant at SP6 in relation to curly coat with/without hypotrichosis (see 002175-9796)Breed: Curly. Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|KRT25||keratin 25, type I||Equus caballus||11||NC_009154.3 (21962667..21968887)||KRT25||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|856||Bashkir Curly Horse Curly||Curly coat||KRT25||Crd||missense||Naturally occurring variant||EquCab3.0||11||g.21962991G>A||c.266G>A||p.(R89H)||rs1095048844||rs1095048844||2018||29686323 29141579||Variant coordinates obtained from and/or confirmed by EBI's Some Effect Predictor (VEP) tool|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2018||Thomer, A., Gottschalk, M., Christmann, A., Naccache, F., Jung, K., Hewicker-Trautwein, M., Distl, O., Metzger, J. :|
|An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Sci Rep 8:6374, 2018. Pubmed reference: 29686323. DOI: 10.1038/s41598-018-24865-3.|
|2017||Morgenthaler, C., Diribarne, M., Capitan, A., Legendre, R., Saintilan, R., Gilles, M., Esquerré, D., Juras, R., Khanshour, A., Schibler, L., Cothran, G. :|
|A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genet Sel Evol 49:85, 2017. Pubmed reference: 29141579. DOI: 10.1186/s12711-017-0359-5.|
|2016||Leroy, G., Besbes, B., Boettcher, P., Hoffmann, I., Capitan, A., Baumung, R. :|
|Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet 47:141-53, 2016. Pubmed reference: 26662214. DOI: 10.1111/age.12393.|
|1990||Sponenberg, D.P. :|
|Dominant Curly Coat in Horses Genetics Selection Evolution 22:257-260, 1990.|
|1989||Thomas, S., Gaier, D., Bowling, A. :|
|Myth and mystery: the curly horse in America. New York: C.S. Fund Inc. :, 1989.|
|1943||Blakeslee, L.H., Hudson, R.S., Hunt, H.R. :|
|Curly coat of horses. Journal of Heredity 34:115-118, 1943.|
|1940||Shcheckin V.A., Kalaev, V.V. :|
|Inheritance of curliness in the horse C.R. (Doklady) Academy of Science U.R.S.S., N.S. 26:262-263, 1940.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 17 Nov 2017
- Changed by Frank Nicholas on 21 Nov 2017
- Changed by Frank Nicholas on 14 Mar 2019