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OMIA:000279-9823 : Diabetes mellitus in Sus scrofa (pig)

In other species: crab-eating macaque , dog , domestic cat , horse , taurine cattle , rabbit , domestic guinea pig , long-tailed chinchilla , koala

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 125850 (trait) , 125851 (trait) , 125852 (trait) , 125853 (trait) , 176730 (gene) , 222100 (trait) , 222300 (trait) , 520000 (trait)

Mendelian trait/disorder: unknown

Disease-related: yes

Species-specific description: Renner et al. (2013): "generated INS(C94Y) transgenic pigs. ... The stable diabetic phenotype and its rescue by insulin treatment make the INS(C94Y) transgenic pig an attractive model for insulin supplementation and islet transplantation trials, and for studying developmental consequences of maternal diabetes mellitus." Genetically-modified organism, GMO Cho et al. (2018) "have successfully generated insulin-deficient pigs by generating the indels of the porcine INS gene in somatic cells using CRISPR/Cas9 system followed by somatic cell nuclear transfer. ... As expected, INS knockout piglets presented high blood glucose levels and glucose was detected in the urine." Genetically-modified organism, GMO Peng et al. (2023) "established diabetes-susceptible transgenic pigs [PIGinH11 pigs] and subjected them to high-fat and high-sucrose dietary interventions. ... Compared to wild-type (WT) pigs, PIGinH11 pigs showed similar pathological manifestations to type 2 diabetes patients ... ." Genetically-modified organism, GMO

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
INS insulin Sus scrofa 2 NC_010444.4 (1498052..1496842) INS Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000279-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Degroote, R.L., Schmalen, A., Renner, S., Wolf, E., Hauck, S.M., Deeg, C.A. :
Diabetic retinopathy from the vitreous proteome perspective: The INS C94Y transgenic pig model study. Proteomics 24:e2300591, 2024. Pubmed reference: 39126128. DOI: 10.1002/pmic.202300591.
Shashikadze, B., Flenkenthaler, F., Kemter, E., Franzmeier, S., Stöckl, J.B., Haid, M., Riols, F., Rothe, M., Pichl, L., Renner, S., Blutke, A., Wolf, E., Fröhlich, T. :
Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus. Dis Model Mech 17:dmm050650, 2024. Pubmed reference: 38900131. DOI: 10.1242/dmm.050650.
2023 Lutz, T.A. :
Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus. Nat Rev Endocrinol 19:350-360, 2023. Pubmed reference: 36941447. DOI: 10.1038/s41574-023-00818-3.
Peng, H., Zhang, K., Miao, J., Yang, Y., Xu, S., Wu, T., Tao, C., Wang, Y., Yang, S. :
SnRNA-Seq of Pancreas Revealed the Dysfunction of Endocrine and Exocrine Cells in Transgenic Pigs with Prediabetes. Int J Mol Sci 24:7701, 2023. Pubmed reference: 37175407. DOI: 10.3390/ijms24097701.
Shashikadze, B., Valla, L., Lombardo, S.D., Prehn, C., Haid, M., Riols, F., Stöckl, J.B., Elkhateib, R., Renner, S., Rathkolb, B., Menche, J., Hrabĕ de Angelis, M., Wolf, E., Kemter, E., Fröhlich, T. :
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model. Mol Metab 75:101768, 2023. Pubmed reference: 37414142. DOI: 10.1016/j.molmet.2023.101768.
Yagihashi, S. :
Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig 14:1015-1037, 2023. Pubmed reference: 37401013. DOI: 10.1111/jdi.14034.
2022 Xu, J., Zhang, K., Qiu, B., Liu, J., Liu, X., Yang, S., Xiao, X. :
Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease. Metabolites 12:1164, 2022. Pubmed reference: 36557202. DOI: 10.3390/metabo12121164.
2021 Kemter, E., Citro, A., Wolf-van Buerck, L., Qiu, Y., Böttcher, A., Policardi, M., Pellegrini, S., Valla, L., Alunni-Fabbroni, M., Kobolák, J., Kessler, B., Kurome, M., Zakhartchenko, V., Dinnyes, A., Cyran, C.C., Lickert, H., Piemonti, L., Seissler, J., Wolf, E. :
Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants. Xenotransplantation 29:e12719, 2021. Pubmed reference: 34935207. DOI: 10.1111/xen.12719.
Tanihara, F., Hirata, M., Otoi, T. :
Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025.
Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2018 Cho, B., Kim, S.J., Lee, E.J., Ahn, S.M., Lee, J.S., Ji, D.Y., Lee, K., Kang, J.T. :
Generation of insulin-deficient piglets by disrupting INS gene using CRISPR/Cas9 system. Transgenic Res 27:289-300, 2018. Pubmed reference: 29691708. DOI: 10.1007/s11248-018-0074-1.
2013 Renner, S., Braun-Reichhart, C., Blutke, A., Herbach, N., Emrich, D., Streckel, E., Wünsch, A., Kessler, B., Kurome, M., Bähr, A., Klymiuk, N., Krebs, S., Puk, O., Nagashima, H., Graw, J., Blum, H., Wanke, R., Wolf, E. :
Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes 62:1505-11, 2013. Pubmed reference: 23274907. DOI: 10.2337/db12-1065.

Edit History


  • Created by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 26 Dec 2021
  • Changed by Imke Tammen2 on 15 May 2023
  • Changed by Imke Tammen2 on 20 Jul 2023
  • Changed by Imke Tammen2 on 10 Dec 2023