OMIA 000279-9986 : Diabetes mellitus in Oryctolagus cuniculus

In other species: domestic cat , dog , cattle , golden hamster , koala , long-tailed chinchilla , domestic guinea pig , horse , pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125850 (trait) , 125851 (trait) , 125852 (trait) , 125853 (trait) , 176730 (gene) , 222100 (trait) , 222300 (trait) , 520000 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Song et al. (2019) developed a "rabbit with a non-frameshift mutation of GCK gene (GCK-NFS) by cytoplasm microinjection of Cas9 mRNA and gRNA. These GCK-NFS rabbits showed typical features of MODY-2 including hyperglycemia and glucose intolerance with similar survival rate and weight compared to wild-type (WT) rabbits." This is a genetically-modified organism (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GCK glucokinase (hexokinase 4) Oryctolagus cuniculus 10 NC_013678.1 (44710934..44700095) GCK Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Song, Y., Sui, T., Zhang, Y., Wang, Y., Chen, M., Deng, J., Chai, Z., Lai, L., Li, Z. :
Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2. Cell Mol Life Sci 16:3265-3277, 2019. Pubmed reference: 31720743. DOI: 10.1007/s00018-019-03354-4.
1998 Ewringmann, A., Gobel, T. :
Diabetes mellitus in rabbits, guinea pigs and chinchillas [German] Kleintierpraxis 43:337 ff., 1998.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 10 Aug 2020