OMIA:000279-9986 : Diabetes mellitus in Oryctolagus cuniculus (rabbit)

In other species: dog , domestic cat , horse , pig , taurine cattle , domestic guinea pig , long-tailed chinchilla , koala

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125850 (trait) , 125851 (trait) , 125852 (trait) , 125853 (trait) , 176730 (gene) , 222100 (trait) , 222300 (trait) , 520000 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Song et al. (2019) developed a "rabbit with a non-frameshift mutation of GCK gene (GCK-NFS) by cytoplasm microinjection of Cas9 mRNA and gRNA. These GCK-NFS rabbits showed typical features of MODY-2 including hyperglycemia and glucose intolerance with similar survival rate and weight compared to wild-type (WT) rabbits." This is a genetically-modified organism (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GCK glucokinase (hexokinase 4) Oryctolagus cuniculus 10 NC_067383.1 (41688871..41678031) GCK Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000279-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Yagihashi, S. :
Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig 14:1015-1037, 2023. Pubmed reference: 37401013. DOI: 10.1111/jdi.14034.
2019 Song, Y., Sui, T., Zhang, Y., Wang, Y., Chen, M., Deng, J., Chai, Z., Lai, L., Li, Z. :
Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2. Cell Mol Life Sci 16:3265-3277, 2019. Pubmed reference: 31720743. DOI: 10.1007/s00018-019-03354-4.
1998 Ewringmann, A., Gobel, T. :
Diabetes mellitus in rabbits, guinea pigs and chinchillas [German] Kleintierpraxis 43:337 ff., 1998.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 10 Aug 2020
  • Changed by Imke Tammen2 on 10 Dec 2023