OMIA:000279-9986 : Diabetes mellitus in Oryctolagus cuniculus
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Song et al. (2019) developed a "rabbit with a non-frameshift mutation of GCK gene (GCK-NFS) by cytoplasm microinjection of Cas9 mRNA and gRNA. These GCK-NFS rabbits showed typical features of MODY-2 including hyperglycemia and glucose intolerance with similar survival rate and weight compared to wild-type (WT) rabbits." This is a genetically-modified organism (GMO).
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|GCK||glucokinase (hexokinase 4)||Oryctolagus cuniculus||10||NC_067383.1 (41688871..41678031)||GCK||Homologene, Ensembl , NCBI gene|
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Yagihashi, S. :|
|Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig :, 2023. Pubmed reference: 37401013 . DOI: 10.1111/jdi.14034.|
|2019||Song, Y., Sui, T., Zhang, Y., Wang, Y., Chen, M., Deng, J., Chai, Z., Lai, L., Li, Z. :|
|Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2. Cell Mol Life Sci 16:3265-3277, 2019. Pubmed reference: 31720743 . DOI: 10.1007/s00018-019-03354-4.|
|1998||Ewringmann, A., Gobel, T. :|
|Diabetes mellitus in rabbits, guinea pigs and chinchillas [German] Kleintierpraxis 43:337 ff., 1998.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 10 Aug 2020