OMIA:000279-9986 : Diabetes mellitus in Oryctolagus cuniculus |
In other species: domestic cat , dog , taurine cattle , koala , long-tailed chinchilla , domestic guinea pig , horse , pig
Categories: Endocrine / exocrine gland phene (incl mammary gland)
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125850 (trait) , 125851 (trait) , 125852 (trait) , 125853 (trait) , 176730 (gene) , 222100 (trait) , 222300 (trait) , 520000 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Song et al. (2019) developed a "rabbit with a non-frameshift mutation of GCK gene (GCK-NFS) by cytoplasm microinjection of Cas9 mRNA and gRNA. These GCK-NFS rabbits showed typical features of MODY-2 including hyperglycemia and glucose intolerance with similar survival rate and weight compared to wild-type (WT) rabbits." This is a genetically-modified organism (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| GCK | glucokinase (hexokinase 4) | Oryctolagus cuniculus | 10 | NC_067383.1 (41688871..41678031) | GCK | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:000279-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Yagihashi, S. : |
| Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig :, 2023. Pubmed reference: 37401013 . DOI: 10.1111/jdi.14034. | |
| 2019 | Song, Y., Sui, T., Zhang, Y., Wang, Y., Chen, M., Deng, J., Chai, Z., Lai, L., Li, Z. : |
| Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2. Cell Mol Life Sci 16:3265-3277, 2019. Pubmed reference: 31720743 . DOI: 10.1007/s00018-019-03354-4. | |
| 1998 | Ewringmann, A., Gobel, T. : |
| Diabetes mellitus in rabbits, guinea pigs and chinchillas [German] Kleintierpraxis 43:337 ff., 1998. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 10 Aug 2020