OMIA:000284-10036 : Diabetes mellitus, type 2 in Mesocricetus auratus (golden hamster) |
In other species: crab-eating macaque , Rhesus monkey , domestic cat , pig , Chinese hamster
Categories: Endocrine / exocrine gland phene (incl mammary gland)
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 125853 (trait) , 147940 (gene) , 137241 (gene) , 600797 (gene)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2024
Molecular basis: Hirose et al. (2024) used CRISPR/Cas9 genome-editing to create an knock out (KO) golden hamster line with a 2653-bp deletion in exon 1 of the Irs2 gene as a model for type 2 diabetes in humans. This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| Irs2 | insulin receptor substrate 2 | Mesocricetus auratus | NW_024429212.1 (8168622..8193089) | Irs2 | Ensembl, NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Variant Type | Variant Effect | Source of Genetic Variant | Pathogenicity Classification* | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1711 | Diabetes mellitus, type 2 | Irs2 | deletion, gross (>20) | Genome-editing (CRISPR-Cas9) | Not currently evaluated | 2653-bp deletion in exon 1 | 2024 | 39134590 |
* Variant pathogenicity for single gene diseases as evaluated by an expert panel of the International Society of Animal Genetics (ISAG) Animal Genetic Testing Standardization Standing Committee
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000284-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2024 | Hirose, M., Inoue, K., Matoba, S., Tatebe, T., Tokita, S., Dodo, Y., Tomishima, T., Hasegawa, A., Honda, A., Ozaki, M., Shinogi, A., Yanagisawa, R., Fauzi, M., Murakami, T., Inagaki, N., Tamura, M., Ogura, A. : |
| Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster. Sci Rep 14:17450, 2024. Pubmed reference: 39134590. DOI: 10.1038/s41598-024-67513-9. |
Edit History
- Created by Imke Tammen2 on 18 Aug 2024
- Changed by Imke Tammen2 on 18 Aug 2024
- Changed by Imke Tammen2 on 02 Sep 2024