OMIA:000284-9823 : Diabetes mellitus, type II in Sus scrofa (pig)

In other species: crab-eating macaque , Rhesus monkey , domestic cat , Chinese hamster

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125853 (trait) , 147940 (gene) , 137241 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Includes studies using genetically-modifed organism; GMO Renner et al. (2010) used transgenesis of the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) to create an animal model of this human disorder due to a dominant-negative GIP receptor in pancreatic cells. Zou et al. (2019) "obtained IAPP gene-humanized miniature pigs via the CRISPR/Cas9 system and somatic cell nuclear transfer (SCNT) technology. The hIAPP pigs can be used to further study the pathogenesis and related complications of T2DM [type 2 diabetes mellitus] and to lay a solid foundation for the prevention and treatment of T2DM." See also 'OMIA:002552-9823 : Pancreatic agenesis, PDX1-related in Sus scrofa' for the creation of a pig model for the investigation of diabetes mellitus (information about PDX1 mutations were initially listed here but have been moved to a new OMIA entry on the 31/5/2022)

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
IAPP islet amyloid polypeptide Homo sapiens 12 NC_000012.12 (21354959..21379980) IAPP Homologene, Ensembl , NCBI gene
GIPR gastric inhibitory polypeptide receptor Sus scrofa 6 NC_010448.4 (52022667..52033959) GIPR Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000284-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Lutz, T.A. :
Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus. Nat Rev Endocrinol 19:350-360, 2023. Pubmed reference: 36941447. DOI: 10.1038/s41574-023-00818-3.
Niu, M., Zhao, Y., Jia, Y., Xiang, L., Dai, X., Chen, H. :
Whole-genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs. Animal Model Exp Med , 2023. Pubmed reference: 37132291. DOI: 10.1002/ame2.12317.
2021 Kemter, E., Citro, A., Wolf-van Buerck, L., Qiu, Y., Böttcher, A., Policardi, M., Pellegrini, S., Valla, L., Alunni-Fabbroni, M., Kobolák, J., Kessler, B., Kurome, M., Zakhartchenko, V., Dinnyes, A., Cyran, C.C., Lickert, H., Piemonti, L., Seissler, J., Wolf, E. :
Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants. Xenotransplantation :e12719, 2021. Pubmed reference: 34935207. DOI: 10.1111/xen.12719.
Tanihara, F., Hirata, M., Otoi, T. :
Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025.
Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2019 Zou, X., Ouyang, H., Yu, T., Chen, X., Pang, D., Tang, X., Chen, C. :
Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system. Cell Death Dis 10:823, 2019. Pubmed reference: 31659151. DOI: 10.1038/s41419-019-2056-5.
2010 Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D.C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Göke, B., Pfeifer, A., Wanke, R., Wolf, E. :
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59:1228-38, 2010. Pubmed reference: 20185813. DOI: 10.2337/db09-0519.

Edit History

  • Created by Frank Nicholas on 31 Mar 2016
  • Changed by Frank Nicholas on 08 Aug 2017
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 26 Dec 2021
  • Changed by Imke Tammen2 on 31 May 2022
  • Changed by Imke Tammen2 on 04 May 2023
  • Changed by Imke Tammen2 on 10 Dec 2023
  • Changed by Imke Tammen2 on 08 Feb 2024