OMIA 000284-9823 : Diabetes mellitus, type II in Sus scrofa

In other species: crab-eating macaque , domestic cat , golden hamster

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125853 (trait) , 147940 (gene) , 137241 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Genetically-modifed organism; GMO

Renner et al. (2010) used transgenesis of the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) to create an animal model of this human disorder due to a dominant-negative GIP receptor in pancreatic cells.

Zou et al. (2019) "obtained IAPP gene-humanized miniature pigs via the CRISPR/Cas9 system and somatic cell nuclear transfer (SCNT) technology. The hIAPP pigs can be used to further study the pathogenesis and related complications of T2DM [type 2 diabetes mellitus] and to lay a solid foundation for the prevention and treatment of T2DM."

See also 'OMIA 002552-9823 : Pancreatic agenesis, PDX1-related in Sus scrofa' for the creation of a pig model for the investigation of diabetes mellitus (information about PDX1 mutations were initially listed here but have been moved to a new OMIA entry on the 31/5/2022)

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
IAPP islet amyloid polypeptide Homo sapiens 12 NC_000012.12 (21354959..21379980) IAPP Homologene, Ensembl, NCBI gene
GIPR gastric inhibitory polypeptide receptor Sus scrofa 6 NC_010448.4 (52022667..52033959) GIPR Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Kemter, E., Citro, A., Wolf-van Buerck, L., Qiu, Y., Böttcher, A., Policardi, M., Pellegrini, S., Valla, L., Alunni-Fabbroni, M., Kobolák, J., Kessler, B., Kurome, M., Zakhartchenko, V., Dinnyes, A., Cyran, C.C., Lickert, H., Piemonti, L., Seissler, J., Wolf, E. :
Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants. Xenotransplantation :e12719, 2021. Pubmed reference: 34935207. DOI: 10.1111/xen.12719.
Tanihara, F., Hirata, M., Otoi, T. :
Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025.
Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2019 Zou, X., Ouyang, H., Yu, T., Chen, X., Pang, D., Tang, X., Chen, C. :
Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system. Cell Death Dis 10:823, 2019. Pubmed reference: 31659151. DOI: 10.1038/s41419-019-2056-5.
2010 Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D.C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Göke, B., Pfeifer, A., Wanke, R., Wolf, E. :
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59:1228-38, 2010. Pubmed reference: 20185813. DOI: 10.2337/db09-0519.

Edit History


  • Created by Frank Nicholas on 31 Mar 2016
  • Changed by Frank Nicholas on 08 Aug 2017
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 26 Dec 2021
  • Changed by Imke Tammen2 on 31 May 2022