OMIA 000284-9823 : Diabetes mellitus, type II in Sus scrofa

In other species: crab-eating macaque , domestic cat , golden hamster

Possibly relevant human trait(s) and/or gene(s) (MIM number): 125852

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Genetically-modifed organism; GMO

Molecular basis: Renner et al. (2010) used transgenesis of the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) to create an animal model of this human disorder due to a dominant-negative GIP receptor in pancreatic cells.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GIPR gastric inhibitory polypeptide receptor Sus scrofa 6 NC_010448.4 (52022667..52033959) GIPR Homologene, Ensembl, NCBI gene


2010 Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D.C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Göke, B., Pfeifer, A., Wanke, R., Wolf, E. :
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59:1228-38, 2010. Pubmed reference: 20185813. DOI: 10.2337/db09-0519.

Edit History

  • Created by Frank Nicholas on 31 Mar 2016
  • Changed by Frank Nicholas on 08 Aug 2017