OMIA:000284-9823 : Diabetes mellitus, type II in Sus scrofa |
In other species: domestic cat , crab-eating macaque , Chinese hamster
Categories: Endocrine / exocrine gland phene (incl mammary gland)
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125853 (trait) , 147940 (gene) , 137241 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Species-specific description: Genetically-modifed organism; GMO
Renner et al. (2010) used transgenesis of the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) to create an animal model of this human disorder due to a dominant-negative GIP receptor in pancreatic cells.
Zou et al. (2019) "obtained IAPP gene-humanized miniature pigs via the CRISPR/Cas9 system and somatic cell nuclear transfer (SCNT) technology. The hIAPP pigs can be used to further study the pathogenesis and related complications of T2DM [type 2 diabetes mellitus] and to lay a solid foundation for the prevention and treatment of T2DM."
See also 'OMIA 002552-9823 : Pancreatic agenesis, PDX1-related in Sus scrofa' for the creation of a pig model for the investigation of diabetes mellitus (information about PDX1 mutations were initially listed here but have been moved to a new OMIA entry on the 31/5/2022)
Associated genes:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| IAPP | islet amyloid polypeptide | Homo sapiens | 12 | NC_000012.12 (21354959..21379980) | IAPP | Homologene, Ensembl , NCBI gene |
| GIPR | gastric inhibitory polypeptide receptor | Sus scrofa | 6 | NC_010448.4 (52022667..52033959) | GIPR | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Lutz, T.A. : |
| Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus. Nat Rev Endocrinol :, 2023. Pubmed reference: 36941447 . DOI: 10.1038/s41574-023-00818-3. | |
| 2021 | Kemter, E., Citro, A., Wolf-van Buerck, L., Qiu, Y., Böttcher, A., Policardi, M., Pellegrini, S., Valla, L., Alunni-Fabbroni, M., Kobolák, J., Kessler, B., Kurome, M., Zakhartchenko, V., Dinnyes, A., Cyran, C.C., Lickert, H., Piemonti, L., Seissler, J., Wolf, E. : |
| Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants. Xenotransplantation :e12719, 2021. Pubmed reference: 34935207 . DOI: 10.1111/xen.12719. | |
| Tanihara, F., Hirata, M., Otoi, T. : | |
| Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678 . DOI: 10.1262/jrd.2021-025. | |
| Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. : | |
| The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928 . DOI: 10.1016/j.jgg.2021.03.015. | |
| 2019 | Zou, X., Ouyang, H., Yu, T., Chen, X., Pang, D., Tang, X., Chen, C. : |
| Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system. Cell Death Dis 10:823, 2019. Pubmed reference: 31659151 . DOI: 10.1038/s41419-019-2056-5. | |
| 2010 | Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D.C., Kessler, B., Ulrichs, K., Chodnevskaja, I., Moskalenko, V., Amselgruber, W., Göke, B., Pfeifer, A., Wanke, R., Wolf, E. : |
| Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59:1228-38, 2010. Pubmed reference: 20185813 . DOI: 10.2337/db09-0519. |
Edit History
- Created by Frank Nicholas on 31 Mar 2016
- Changed by Frank Nicholas on 08 Aug 2017
- Changed by Imke Tammen2 on 25 Jun 2021
- Changed by Imke Tammen2 on 26 Dec 2021
- Changed by Imke Tammen2 on 31 May 2022