OMIA 000284-9685 : Diabetes mellitus, type II in Felis catus

In other species: crab-eating macaque , pig , golden hamster

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 125853 (trait) , 600733 (gene) , 147940 (gene) , 137241 (gene)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: O'Leary et al. (2013): "In this pilot study the increased inbreeding in the cases, lack of likely sampling bias, the increased frequency of T2D in Burmese, and small number of breed founders are consistent with the involvement of a major locus in diabetes in Burmese cats with a significant risk allele prevalence. However, low case numbers meant this could not be unambiguously confirmed. A genome-wide association study may be useful for investigating the genetic cause of T2D."

Mapping: Samaha et al. (2020): "We used the feline SNV array and whole genome sequence data to undertake a genome wide-association study and runs of homozygosity analysis, of a case-control cohort of Australian and European Burmese cats. Our results identified diabetes-associated haplotypes across chromosomes A3, B1 and E1 and selective sweeps across the Burmese breed on chromosomes B1, B3, D1 and D4."

Balmer et al. (2020) conducted "a genome-wide association scan on ABB [Australian-bred Burmese] cats. Four SNPs were associated with the ABB T2D phenotype with p values <0.005. ... These SNPs tagged regions on cat chromosomes A3, C1 and C2. ... All exons and splice junctions of candidate genes near significant single-nucleotide polymorphisms (SNPs) were sequenced, including the genes DGKG, IFG2BP2, SLC8A1, E2F6, ETV5, TRA2B and LIPH. Six candidate polymorphisms were followed up in a larger cohort of ABB cats with or without T2D and also in Burmese cats bred in America, which exhibit low T2D incidence. The original SNPs were confirmed in this cohort as associated with the T2D phenotype, although no novel coding SNPs in any of the seven candidate genes showed association with T2D."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Balmer, L., O'Leary, C.A., Menotti-Raymond, M., David, V., O'Brien, S., Penglis, B., Hendrickson, S., Reeves-Johnson, M., Gottlieb, S., Fleeman, L., Vankan, D., Rand, J., Morahan, G. :
Mapping of diabetes susceptibility loci in a domestic cat breed with an unusually high incidence of diabetes mellitus. Genes (Basel) 11:1369, 2020. Pubmed reference: 33228033. DOI: 10.3390/genes11111369.
Samaha, G., Wade, C.M., Beatty, J., Lyons, L.A., Fleeman, L.M., Haase, B. :
Mapping the genetic basis of diabetes mellitus in the Australian Burmese cat (Felis catus). Sci Rep 10:19194, 2020. Pubmed reference: 33154479. DOI: 10.1038/s41598-020-76166-3.
2019 Samaha, G., Beatty, J., Wade, C.M., Haase, B. :
The Burmese cat as a genetic model of type 2 diabetes in humans. Anim Genet 50:319-325, 2019. Pubmed reference: 31179570. DOI: 10.1111/age.12799.
2013 Forcada, Y., Holder, A., Church, D.B., Catchpole, B. :
A polymorphism in the Melanocortin 4 Receptor Gene (MC4R:c.92C>T) is associated with diabetes mellitus in overweight domestic shorthaired cats. J Vet Intern Med :, 2013. Pubmed reference: 24372947. DOI: 10.1111/jvim.12275.
O'Leary, C.A., Duffy, D.L., Gething, M.A., McGuckin, C., Rand, J.S. :
Investigation of diabetes mellitus in Burmese cats as an inherited trait: a preliminary study. N Z Vet J 61:354-8, 2013. Pubmed reference: 23909918. DOI: 10.1080/00480169.2013.817295.
1997 Greco, D.S. :
Oral hypoglycemic agents for noninsulin-dependent diabetes mellitus in the cat Seminars in Veterinary Medicine & Surgery (Small Animal) 12:259-262, 1997. Pubmed reference: 10889874.
Struble, A.L., Nelson, R.W. :
Non-insulin dependent diabetes mellitus in cats and humans Compendium on Continuing Education for the Practicing Veterinarian 19:935 ff., 1997.
1993 Kirk, C.A., Feldman, E.C., Nelson, R.W. :
Diagnosis of Naturally Acquired Type-I and Type-II Diabetes- Mellitus in Cats American Journal of Veterinary Research 54:463-467, 1993. Pubmed reference: 8498753.
Lutz, T.A., Rand, J.S. :
A Review of New Developments in Type 2 Diabetes in Human Beings and Cats British Veterinary Journal 149:527-536, 1993. Pubmed reference: 8111613. DOI: 10.1016/S0007-1935(05)80037-5.
Nelson, R.W., Feldman, E.C. :
Noninsulin-Dependent Diabetes-Mellitus in the Cat (Reprinted from Proceedings of the 10th Annual Veterinary Forum, May, 1992) Feline Practice 21:15-17, 1993.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 20 Sep 2019
  • Changed by Imke Tammen2 on 11 Dec 2020