OMIA 000303-9031 : Dwarfism, autosomal in Gallus gallus

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: yes

Key variant known: no

Species-specific description: Two types of dwarfism in mice are due to mutations in genes that map to the region of chromosome 1 in chicken known to contain the gene for autosomal dwarfism in this species. However, neither of these genes (high mobility group protein I-C [HMGI-C], insulin-like growth factor 1 [IGF1]) is responsible for the phenotype in chickens (Ruyterspira et al., 1998)..

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2000 Cole, RK. :
An autosomal dwarfism in the domestic fowl. Poult Sci 79:1507-16, 2000. Pubmed reference: 11092317.
1998 Ruyterspira, C.P., Degroof, A.J.C., Vanderpeel, J.J., Herbergs, J., Masabanda, J., Fries, R., Groenen, M.A.M. :
The HMGI-C gene is a likely candidate for the autosomal dwarf locus in the chicken Journal of Heredity 89:295-300, 1998. Pubmed reference: 9703685.
Ruyterspira, C.P., Herbergs, J., Limpens, E., Marsh, J.A., Vanderpoel, J.J., Ayoubi, T.A.Y., Groenen, M.A.M. :
Nucleotide sequence of the chicken HMGI-C cDNA and expression of the HMGI-C and IGF1 genes in autosomal dwarf chicken embryos BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1399:83-87, 1998.
1989 Lam, S.K., Harvey, S., Scanes, C.G. :
Thyroid Function in Sex-Linked and Autosomal Dwarf Chickens General and Comparative Endocrinology 76:200-204, 1989. Pubmed reference: 2574126.

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  • Created by Frank Nicholas on 06 Sep 2005