OMIA 000357-8128 : Eye colour in Oreochromis niloticus
In other species: rock pigeon , dog , domestic cat , water buffalo Mendelian trait/disorder: yes Considered a defect: unknown Key variant known: no Species-specific description: Wang et al. (2021): "We identified 4 types of pigment cells: melanophores, xanthophores, iridophores and erythrophores, and characterized their first appearance in wild-type fish. We mutated 25 genes involved in melanogenesis, pteridine metabolism, and the carotenoid absorption and cleavage pathways. Among the 25 mutated genes, 13 genes had a phenotype in both the F0 and F2 generations. None of F1 heterozygotes had phenotype. By comparing the color pattern of our mutants with that of red tilapia (Oreochromis spp), a natural mutant produced during hybridization of tilapia species, we found that the pigmentation of the body and eye is controlled by different genes. Previously studied genes like mitf, kita/kitlga, pmel, tyrb, hps4, gch2, csf1ra, pax7b, and bco2b were proved to be of great significance for color patterning in tilapia." Inheritance: CRISPR/Cas9 gene editing was used to create mutations (GMO).
|2021||Wang, C., Lu, B., Li, T., Liang, G., Xu, M., Liu, X., Tao, W., Zhou, L., Kocher, T.D., Wang, D. :|
|Nile tilapia: A model for studying teleost color patterns. J Hered 112:469-484, 2021. Pubmed reference: 34027978. DOI: 10.1093/jhered/esab018.|
- Created by Imke Tammen2 on 26 May 2021