OMIA:000383-9925 : Fecundity, BMPR1B-related in Capra hircus (goat)

In other species: sheep

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 134720 (trait) , 609441 (trait) , 603248 (gene)

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific description: Bi et al. (2021) investigated Fec B expression in six different goat tissues, and analyzed the effect of five potential copy number variations (CNVs) (CNV1-5) within the Fec B gene on litter size. The authors propose that CNV3 and CNV5 could serve as potential DNA molecular markers. Jose et al. (2023) report creation of a FecB mutation into goat embryos using CRISPR technology (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000383-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Ullah, I., Khan, R., Suhail, S.M., Ahmad, I., Khan, F.A., Shoaib, M., Farid, K., Ayari-Akkari, A., Morfeine, E.A. :
Association of polymorphism in the promotor area of the caprine BMPR1B gene with litter size and body measurement traits in Damani goats. Trop Anim Health Prod 56:137, 2024. Pubmed reference: 38649642. DOI: 10.1007/s11250-024-03991-3.
2023 Jose, B., Punetha, M., Tripathi, M.K., Khanna, S., Yadav, V., Singh, A.K., Kumar, B., Singh, K., Chouhan, V.S., Sarkar, M. :
CRISPR/Cas mediated disruption of BMPR-1B gene and introduction of FecB mutation into the Caprine embryos using Easi-CRISPR strategy. Theriogenology 211:125-133, 2023. Pubmed reference: 37619525. DOI: 10.1016/j.theriogenology.2023.08.008.
Song, T., Liu, Y., Cuomu, R., Tan, Y., A Wang, C., De, J., Cao, X., Zeng, X. :
Polymorphisms analysis of BMP15, GDF9 and BMPR1B in Tibetan Cashmere Goat (Capra hircus). Genes (Basel) 14, 2023. Pubmed reference: 37239462. DOI: 10.3390/genes14051102.
2021 Bi, Y., Feng, W., Kang, Y., Wang, K., Yang, Y., Qu, L., Chen, H., Lan, X., Pan, C. :
Detection of mRNA expression and copy number variations within the goat FecB gene associated with litter size. Front Vet Sci 8:758705, 2021. Pubmed reference: 34733908. DOI: 10.3389/fvets.2021.758705.
2013 Pramod, R.K., Sharma, S.K., Singhi, A., Pan, S., Mitra, A. :
Differential ovarian morphometry and follicular expression of BMP15, GDF9 and BMPR1B influence the prolificacy in goat. Reprod Domest Anim 48:803-9, 2013. Pubmed reference: 23581245. DOI: 10.1111/rda.12165.

Edit History


  • Created by Imke Tammen2 on 24 Nov 2021
  • Changed by Imke Tammen2 on 27 Aug 2023
  • Changed by Imke Tammen2 on 10 Dec 2023