OMIA 000383-9940 : Fecundity, Booroola, FecB(B) in Ovis aries

Possibly relevant human trait(s) and/or gene(s) (MIM number): 134720

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Semi-Dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2001

Species-specific symbol: FecB(B)

Species-specific description: On their farm called 'Booroola' near Cooma in New South Wales, Australia, the Seears brothers developed a prolific strain of Merino, with an average litter size of more than 2, in contrast to the usual litter size of Merinos, which is less than 1. Sheep from this flock were studied by the CSIRO (Helen Turner, Laurie Piper, Bernie Bindon and colleagues), and it was eventually shown that the prolificacy of the Booroola strain was due to a single gene of large effect, which acts additively for both ovulation rate and litter size (Piper and Bindon, 1982; Davis et al., 1982; Piper et al., 1985). The difference between homozygotes is approximately 2.7-3.0 in ovulation rate and 1.1-1.7 in litter size. The genetical and physiological basis of the Booroola's prolificacy was also studied extensively by New Zealand researchers, who provided one of the first examples of the practical application of gene mapping in sheep, by mapping the Booroola gene to chromosome 6 (Montgomery et al., 1993, 1994), as described in the Mapping section below.

History: The first reports of the segregation of a major gene for fecundity in Booroola Merinos were by Piper et al. (1982; both papers) and Davis et al. (1982).

Mapping: The first attempts to linkage-map the FecB gene involved just 18 polymorphic protein markers (Tate et al., 1992) and 11 polymorphic blood markers (Nguyen et al., 1992). In neither case was any marker linked to FecB, thus enabling the researchers to exclude regions of the as-yet unknown sheep genome in the vicinity of those markers.

The following year, still "in the absence of any genetic map for sheep", Montgomery et al. (1993) assembled a veritable arsenal of 137 markers: "55 known RFLPs, 58 random sheep microsatellites and 24 random RFLP markers". Two of the microsatellites were found to be linked to FecB, namely OarAE101 (13cM) and OarHH55 (20cM). More importantly, an RFLP in the SPP1 gene was also found to be linked to FecB (14 cM). Noting that SPP1 in humans is located on chromosome HSA4q, Montgomery et al. (1993) then examined RFLPs in other genes in that region of HSA4q, and found another HSA4q gene linked to FecB, namely EGF (26 cM). The authors concluded that the most likely location of the FecB gene in the sheep genome is between the sheep versions of SPP1 and EGF. It is an interesting sign of the then times that the actual sheep chromosome on which these markers are located had not yet been determined. Consequently, the title of the paper referred to the FecB gene having been mapped to "a region of human chromosome 4q". The importance of this result at that time is indicated by the paper appearing in Nature Genetics, and by the results stimulating Dr McKusick to create an entry entitled "Fecundity gene, Booroola, of sheep, homolog of" in the human gene catalogue OMIM (see above link to OMIM 134720).

The identity of the chromosome was revealed the next year, when Montgomery et al. (1994) used a sheepxhamster somatic cell hydrid panel to physically map the markers linked to FecB, to sheep chromosome OVA6.

The following year, Montgomery et al. (1995) reported that some fine-mapping in the FecB region had narrowed down the region to near the centromere of OVA6.

Molecular basis: The molecular basis of FecB was finally resolved by three independent groups of researchers, in three separate papers published within a month of each other in 2001.

Working on New Zealand Booroola sheep, Wilson et al. (2001; published 1 April) fine-mapped FecB to a 4cM region of OVA6, and then identified a microsatellite marker (JL36) with zero recombination with FecB, homologous with HSA4q21-24. The most likely candidate gene in this region was the gene encoding the receptor for BMP-IB, i.e. the BMPR-IB gene. Sequencing of the ovine BMPR-IB gene revealed "a point mutation (an A to G transition) at position 830 . . . This translates to a change from a glutamine (neutral/polar amino acid) to an arginine (basic amino acid) at position 249 of the protein [Q249R] . . . in the intracellular kinase signaling domain of the BMPR-IB. Glutamine is conserved at this position in most of the type I receptors."

Working on a flock of Booroolas in France, Mulsant et al. (2001; 24 April) did their own fine-mapping and comparative mapping, also ending up with the BMPR-IB gene as the most likely comparative positional candidate. Sequencing revealed the same Q249R mutation.

Working with Booroola sheep in Edinburgh and Brazil, Souza et al. (2001; 1 May) also zeroed in on BMPR-IB as the most likely comparative positional candidate gene, and identified the same Q249R mutation.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
BMPR1B bone morphogenetic protein receptor type IB Ovis aries 6 NC_019463.2 (29461660..29295574) BMPR1B Homologene, Ensembl, NCBI gene

Variants

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Booroola Fecundity, Booroola, FecB(B) BMPR1B missense Oar_v3.1 6 g.29382188A>G c.914A>G p.Q305R 2001 11259271 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Goyal, S., Aggarwal, J., Dubey, P.K., Mishra, B.P., Ghalsasi, P., Nimbkar, C., Joshi, B.K., Kataria, R.S. :
Expression Analysis of Genes Associated with Prolificacy in FecB Carrier and Noncarrier Indian Sheep. Anim Biotechnol 28:220-227, 2017. Pubmed reference: 28075701. DOI: 10.1080/10495398.2016.1262869.
2016 Leroy, G., Besbes, B., Boettcher, P., Hoffmann, I., Capitan, A., Baumung, R. :
Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet 47:141-53, 2016. Pubmed reference: 26662214. DOI: 10.1111/age.12393.
2014 Mahdavi, M., Nanekarani, S., Hosseini, S.D. :
Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep. Anim Reprod Sci 147:93-8, 2014. Pubmed reference: 24793585. DOI: 10.1016/j.anireprosci.2014.04.003.
2013 Juengel, J.L., Davis, G.H., McNatty, K.P. :
Using sheep lines with mutations in single genes to better understand ovarian function. Reproduction 146:R111-23, 2013. Pubmed reference: 23801782. DOI: 10.1530/REP-12-0509.
2012 Ganai, T.A., Misra, S.S., Shabir, M. :
Polymorphism analysis of BMPR1B gene by forced RFLP and PCR-SSCP techniques and expression of the mutation in introgressed sheep. Trop Anim Health Prod 44:277-83, 2012. Pubmed reference: 22086410. DOI: 10.1007/s11250-011-0015-y.
Reader, K.L., Haydon, L.J., Littlejohn, R.P., Juengel, J.L., McNatty, K.P. :
Booroola BMPR1B mutation alters early follicular development and oocyte ultrastructure in sheep. Reprod Fertil Dev 24:353-61, 2012. Pubmed reference: 22281082. DOI: 10.1071/RD11095.
2011 Banerjee, S., Galloway, S.M., Davis, G.H. :
Distribution of prolific Garole sheep in West Bengal, India Animal Genetic Resources 48:29-35, 2011.
Chu, M., Jia, L., Zhang, Y., Jin, M., Chen, H., Fang, L., Di, R., Cao, G., Feng, T., Tang, Q., Ma, Y., Li, K. :
Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep. Mol Biol Rep 38:4071-6, 2011. Pubmed reference: 21110108. DOI: 10.1007/s11033-010-0526-z.
Crawford, J.L., Heath, D.A., Reader, K.L., Quirke, L.D., Hudson, N.L., Juengel, J.L., McNatty, K.P. :
Oocytes in sheep homozygous for a mutation in bone morphogenetic protein receptor 1B express lower mRNA levels of bone morphogenetic protein 15 but not growth differentiation factor 9. Reproduction 142:53-61, 2011. Pubmed reference: 21474605. DOI: 10.1530/REP-10-0485.
Javanmard, A., Azadzadeh, N., Esmailizadeh, A.K. :
Mutations in bone morphogenetic protein 15 and growth differentiation factor 9 genes are associated with increased litter size in fat-tailed sheep breeds. Vet Res Commun 35:157-67, 2011. Pubmed reference: 21327517. DOI: 10.1007/s11259-011-9467-9.
Roy, J., Polley, S., De, S., Mukherjee, A., Batabyal, S., Pan, S., Brahma, B., Datta, T.K., Goswami, S.L. :
Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim Biotechnol 22:151-62, 2011. Pubmed reference: 21774623. DOI: 10.1080/10495398.2011.589239.
2010 Polley, S., De, S., Brahma, B., Mukherjee, A., Vinesh, P.V., Batabyal, S., Arora, J.S., Pan, S., Samanta, A.K., Datta, T.K., Goswami, S.L. :
Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep. Trop Anim Health Prod 42:985-93, 2010. Pubmed reference: 20020203. DOI: 10.1007/s11250-009-9518-1.
2009 Hua, GH., Yang, LG. :
A review of research progress of FecB gene in Chinese breeds of sheep. Anim Reprod Sci :, 2009. Pubmed reference: 19201555. DOI: 10.1016/j.anireprosci.2009.01.001.
Li, Y.L., Chu, M.X., Chen, H.Q., Fang, L., DI, R., Ma, Y.H., Li, K. :
[Polymorphic and linkage analysis of microsatellite BMS2508 and FecB gene in sheep]. Yi Chuan 31:500-7, 2009. Pubmed reference: 19586845.
Mishra, AK., Arora, AL., Kumar, S., Prince, LL. :
Studies on effect of Booroola (FecB) genotype on lifetime ewes' productivity efficiency, litter size and number of weaned lambs in Garole x Malpura sheep. Anim Reprod Sci 113:293-8, 2009. Pubmed reference: 18620822. DOI: 10.1016/j.anireprosci.2008.06.002.
Ruoss, C., Tadros, A., O'Shea, T., McFarlane, J., Almahbobi, G. :
Ovarian follicle development in Booroola sheep exhibiting impaired bone morphogenetic protein signalling pathway. Reproduction 138:689-96, 2009. Pubmed reference: 19589856. DOI: 10.1530/REP-09-0190.
2008 Gootwine, E., Reicher, S., Rozov, A. :
Prolificacy and lamb survival at birth in Awassi and Assaf sheep carrying the FecB (Booroola) mutation. Anim Reprod Sci 108:402-11, 2008. Pubmed reference: 17997056. DOI: 10.1016/j.anireprosci.2007.09.009.
Kumar, S., Mishra, AK., Kolte, AP., Arora, AL., Singh, D., Singh, VK. :
Effects of the Booroola (FecB) genotypes on growth performance, ewe's productivity efficiency and litter size in Garole x Malpura sheep. Anim Reprod Sci 105:319-31, 2008. Pubmed reference: 17449205. DOI: 10.1016/j.anireprosci.2007.03.012.
Young, JM., Juengel, JL., Dodds, KG., Laird, M., Dearden, PK., McNeilly, AS., McNatty, KP., Wilson, T. :
The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures. J Endocrinol 196:251-61, 2008. Pubmed reference: 18252948. DOI: 10.1677/JOE-07-0148.
2007 Chu, MX., Liu, ZH., Jiao, CL., He, YQ., Fang, L., Ye, SC., Chen, GH., Wang, JY. :
Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries). J Anim Sci 85:598-603, 2007. Pubmed reference: 17040942. DOI: 10.2527/jas.2006-324.
Guan, F., Liu, SR., Shi, GQ., Yang, LG. :
Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development. Anim Reprod Sci 99:44-52, 2007. Pubmed reference: 16859845. DOI: 10.1016/j.anireprosci.2006.04.048.
2006 Campbell, BK., Souza, CJ., Skinner, AJ., Webb, R., Baird, DT. :
Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2, -4, and -6. Endocrinology 147:1608-20, 2006. Pubmed reference: 16396991. DOI: 10.1210/en.2005-0604.
Davis, GH., Balakrishnan, L., Ross, IK., Wilson, T., Galloway, SM., Lumsden, BM., Hanrahan, JP., Mullen, M., Mao, XZ., Wang, GL., Zhao, ZS., Zeng, YQ., Robinson, JJ., Mavrogenis, AP., Papachristoforou, C., Peter, C., Baumung, R., Cardyn, P., Boujenane, I., Cockett, NE., Eythorsdottir, E., Arranz, JJ., Notter, DR. :
Investigation of the Booroola (FecB) and Inverdale (FecX(I)) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries. Anim Reprod Sci 92:87-96, 2006. Pubmed reference: 15982834. DOI: 10.1016/j.anireprosci.2005.06.001.
Gootwine, E., Rozov, A., Bor, A., Reicher, S. :
Carrying the FecB (Booroola) mutation is associated with lower birth weight and slower post-weaning growth rate for lambs, as well as a lighter mature bodyweight for ewes. Reprod Fertil Dev 18:433-7, 2006. Pubmed reference: 16737636.
2005 Davis, GH. :
Major genes affecting ovulation rate in sheep. Genet Sel Evol 37 Suppl 1:S11-23, 2005. Pubmed reference: 15601592. DOI: 10.1051/gse:2004026.
Guan, F., Yang, LG., An, JT., Liu, SR., Shi, GQ. :
[Development of a rapid mismatch PCR method using tetra-primer ARMS for detection of BMPR-IB gene mutation in sheep] Yi Chuan 27:579-83, 2005. Pubmed reference: 16120582.
2004 Davis, GH. :
Fecundity genes in sheep. Anim Reprod Sci 82-83:247-53, 2004. Pubmed reference: 15271457. DOI: 10.1016/j.anireprosci.2004.04.001.
Gonzalez-Bulnes, A., Souza, CJ., Campbell, BK., Baird, DT. :
Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the Booroola gene. Endocrinology 145:2858-64, 2004. Pubmed reference: 15016720. DOI: 10.1210/en.2003-1722.
Souza, C.J., González-Bulnes, A., Campbell, B.K., McNeilly, A.S., Baird, D.T. :
Mechanisms of action of the principal prolific genes and their application to sheep production. Reprod Fertil Dev 16:395-401, 2004. Pubmed reference: 15315738. DOI: 10.10371/RD04038.
Souza, CJ., Baird, DT. :
The Booroola (FecB) mutation is associated with smaller adrenal glands in young adult ewes. Reprod Biomed Online 8:414-8, 2004. Pubmed reference: 15149564.
2003 Campbell, B.K., Baird, D.T., Souza, C.J., Webb, R. :
The FecB (Booroola) gene acts at the ovary: in vivo evidence Reproduction 126:101-11, 2003. Pubmed reference: 12814352.
Fabre, S., Pierre, A., Pisselet, C., Mulsant, P., Lecerf, F., Pohl, J., Monget, P., Monniaux, D. :
The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality Journal of Endocrinology 177:435-44, 2003. Pubmed reference: 12773124.
Hanrahan, J.P. :
Aspects of reproductive performance in small ruminants--opportunities and challenges. Reprod Suppl 61:15-26, 2003. Pubmed reference: 14635923.
Liu, SF., Yan, YC., Du, LX. :
[Advances on localization and molecular mechanism of FecB gene] Yi Chuan 25:93-6, 2003. Pubmed reference: 15639829.
Souza, CJ., Campbell, BK., McNeilly, AS., Baird, DT. :
Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation. Reprod Suppl 61:361-70, 2003. Pubmed reference: 14635948.
Xia, Y., O'Shea, T., Murison, R., McFarlane, JR. :
Concentrations of progesterone, follistatin, and follicle-stimulating hormone in peripheral plasma across the estrous cycle and pregnancy in merino ewes that are homozygous or noncarriers of the Booroola gene. Biol Reprod 69:1079-84, 2003. Pubmed reference: 12773419. DOI: 10.1095/biolreprod.102.005512.
2002 Davis, G.H., Galloway, S.A., Ross, I.K., Gregan, S.M., Ward, J., Nimbkar, B.V., Ghalsasi, P.M., Nimbkar, C., Gray, G.D., Subandriyo., Inounu, I., Tiesnamurti, B., Martyniuk, E., Eythorsdottir, E., Mulsant, P., Lecerf, F., Hanrahan, J.P., Bradford, G.E., Wilson, T. :
DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation Biology of Reproduction 66:1869-1874, 2002. Pubmed reference: 12021074.
Monget, P., Fabre, S., Mulsant, P., Lecerf, F., Elsen, J.M., Mazerbourg, S., Pisselet, C., Monniaux, D. :
Regulation of ovarian folliculogenesis by IGF and BMP system in domestic animals. Domest Anim Endocrinol 23:139-54, 2002. Pubmed reference: 12142233.
Southey, B.R., Thomas, D.L., Gottfredson, R.G., Zelinsky, R.D. :
Ewe productivity of Booroola Merino-Rambouillet crossbred sheep during early stages of the introgression of the Fec(B) allele into a Rambouillet population Livestock Production Science 75:33-44, 2002.
2001 Duffy, D.L., Montgomery, G.W., Hall, J., Mayne, C., Healey, S.C., Brown, J., Boomsma, D.I., Martin, N.G. :
Human twinning is not linked to the region of chromosome 4 syntenic with the sheep twinning gene FecB American Journal of Medical Genetics 100:182-186, 2001. Pubmed reference: 11343301.
Gootwine, E., Zenu, A., Bor, A., Yossafi, S., Rosov, A., Pollott, G.E. :
Genetic and economic analysis of introgression the B allele of the FecB (Booroola) gene into the Awassi and Assaf dairy breeds Livestock Production Science 71:49-58, 2001.
Keszka, J., Jaszczak, K., Klewiec, J. :
High frequency of lymphocyte chimerism XX/XY and an analysis of hereditary occurrence of placental anastomoses in Booroola sheep Journal of Animal Breeding & Genetics-Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 118:135-140, 2001.
McNatty, K.P., Juengel, J.L., Wilson, T., Galloway, S.M., Davis, G.H. :
Genetic mutations influencing ovulation rate in sheep Reproduction, Fertility and Development 13:549-555, 2001. Pubmed reference: 11999305.
Montgomery, G.W., Galloway, S.M., Davis, G.H., McNatty, K.P. :
Genes controlling ovulation rate in sheep Reproduction 121:843-852, 2001. Pubmed reference: 11373170.
Mulsant, P., Lecerf, F., Fabre, S., Schibler, L., Monget, P., Lanneluc, I., Pisselet, C., Riquet, J., Monniaux, D., Callebaut, I., Cribiu, E., Thimonier, J., Teyssier, J., Bodin, L., Cognie, Y., Chitour, N., Elsen, J.M. :
Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes Proceedings of the National Academy of Sciences of the United States of America 98:5104-5109, 2001. Pubmed reference: 11320249. DOI: 10.1073/pnas.091577598.
Nowak, Z., Charon, KM. :
Identification of fecundity gene (FecB) carriers using microsatellite markers and its effect on sheep weight. J Appl Genet 42:49-57, 2001. Pubmed reference: 14564063.
Souza, C.J.H., MacDougall, C., Campbell, B.K., McNeilly, A.S., Baird, D.T. :
The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene Journal of Endocrinology 169:R1-R6, 2001. Pubmed reference: 11312159.
Weimann, C., Leyhe-Horn, B., Gauly, M., Erhardt, G. :
Suitability of microsatellites BM1329 and OarAE101 as markers for the introgression of the Fec(B) locus into different sheep breeds Archiv fur Tierzucht-Archives of Animal Breeding 44:435-440, 2001.
Wilson, T., Wu, X.Y., Juengel, J.L., Ross, I.K., Lumsden, J.M., Lord, E.A., Dodds, K.G., Walling, G.A., McEwan, J.C., O'Connell, A.R., McNatty, K.P., Montgomery, G.W. :
Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells Biology of Reproduction 64:1225-1235, 2001. Pubmed reference: 11259271.
2000 Dufour, J.J., Cognie, Y., Mermillod, P., Mariana, J.C., Romain, R.F. :
Effects of the Booroola Fec gene on ovarian follicular populations in superovulated Romanov ewes pretreated with a GnRH antagonist Journal of Reproduction & Fertility 118:85-94, 2000. Pubmed reference: 10793629.
Mandiki, S.N.M., Noel, B., Bister, J.L., Peeters, R., Beerlandt, G., Decuypere, E., Visscher, A., Suess, R., Kaulfuss, K.H., Paquay, R. :
Pre-ovulatory follicular characteristics and ovulation rates in different breed crosses, carriers or non-carriers of the Booroola or Cambridge fecundity gene Animal Reproduction Science 63:77-88, 2000. Pubmed reference: 10967242.
Suess, R., Heylen, K., von, Lengerken, G. :
The effect of Booroola on fat content and fat quality of carcasses in crosses with German Mutton Merinos [German] Archiv fur Tierzucht-Archives of Animal Breeding 43:45-56, 2000.
Visscher, A.H., Dijkstra, M., Lord, E.A., Suss, R., Rosler, H.J., Heylen, K., Veerkamp, R.E. :
Maternal and lamb carrier effects of the Booroola gene on food intake, growth and carcass quality of male lambs Animal Science 71:209-217, 2000.
1999 Dickie, A.M., Paterson, C., Anderson, J.L.M., Boyd, J.S. :
Determination of corpora lutea numbers in Booroola - Texel ewes using transrectal ultrasound Theriogenology 51:1209-1224, 1999. Pubmed reference: 10729086. DOI: 10.1016/S0093-691X(99)00066-7.
Hudson, N.L., O'Connell, A.R., Shaw, L., Clarke, I.J., McNatty, K.P. :
Effect of exogenous FSH on ovulation rate in homozygous carriers or noncarriers of the Booroola FecB gene after hypothalamic-pituitary disconnection or after treatment with a GnRH agonist Domestic Animal Endocrinology 16:69-80, 1999. Pubmed reference: 10081664.
Magyar, K., Veress, L., Tasi, Z., Pecsi, T., Babik, S., Horvath, I. :
Zootechnical and genetic aspects of a Prolific Merino program Acta Veterinaria Hungarica 47:17-31, 1999. Pubmed reference: 10213926. DOI: 10.1556/AVet.47.1999.1.2.
1998 Cognie, Y., Benoit, F., Poulin, N., Khatir, H., Driancourt, M.A. :
Effect of follicle size and of the Fec(B) Booroola gene on oocyte function in sheep Journal of Reproduction & Fertility 112:379-386, 1998. Pubmed reference: 9640277.
Janiuk, W., Baranowski, A., Klewiec, J. :
Performance and slaughter value of Polish Merino, Booroola and Suffolk crossbred lambs Journal of Animal & Feed Sciences 7:161-170, 1998.
Lord, E.A., Davis, G.H., Dodds, K.G., Henry, H.M., Lumsden, J.M., Montgomery, G.W. :
Identification of Booroola carriers using microsatellite markers (Reprinted) Wool Technology & Sheep Breeding 46:245-249, 1998.
Nieuwhof, G.J., Visscher, A.H., Engel, B., Vanderwerf, J.H.J., Dejong, F.H., Dijkstra, M. :
Identification of early predictors of carriers of the Booroola gene in sheep using a mixed inheritance model Animal Science 67:317-325, 1998.
Webb, R., Driancourt, M.A., Hanrahan, J.P. :
Ovulation rate in the ewe: Mechanisms underlying genetic variation Wool Technology & Sheep Breeding 46:343-352, 1998.
1997 Hochereaudereviers, M.T., Perreau, C., Cognie, Y. :
Effects of the Booroola gene Fecb(B) on somatic and germ cells of the fetal testis Reproduction, Nutrition, Development 37:627-635, 1997. Pubmed reference: 9477432.
Souza, C.J.H., Campbell, B.K., Webb, R., Baird, D.T. :
Secretion of inhibin a and follicular dynamics throughout the estrous cycle in the sheep with and without the Booroola gene (Fec(B)) Endocrinology 138:5333-5340, 1997. Pubmed reference: 9389518.
1996 Driancourt, M.A., Gormon, T., Thanh, L.P., Boomarov, O. :
Analysis by two-dimensional electrophoresis of proteins secreted by sheep ovarian follicles - effects of the Fec(b) gene, follicle size and atresia Journal of Reproduction & Fertility 107:69-77, 1996. Pubmed reference: 8699436.
Fahmy, M.H. :
Growth, fertility, prolificacy and fleece weight of romanov, finnsheep and booroola purebreds and their first cross and backcross with the dls breed Animal Science 62:479-487, 1996.
Heath, D.A., Caldani, M., Mcnatty, K.P. :
Relationships between the number of immunostaining gonadotropes and the plasma concentrations of gonadotrophins in ewes with and without the fecb(b) gene Journal of Reproduction & Fertility 106:73-78, 1996. Pubmed reference: 8667350.
Smith, P., Hudson, N.L., Corrigan, K.A., Shaw, L., Smith, T., Phillips, D.J., Mcnatty, K.P. :
Effects of the Booroola gene (FecB(B)) on bodymass, testis development and hormone concentrations during fetal life Journal of Reproduction & Fertility 108:253-261, 1996. Pubmed reference: 9038784.
Wheaton, J.E., Thomas, D.L., Kusina, N.T., Gottfredson, R.G., Meyer, R.L. :
Effects of passive immunization against inhibin-peptide on secretion of follicle-stimulating hormone and ovulation rate in ewes carrying the booroola fecundity gene Biology of Reproduction 55:1351-1355, 1996. Pubmed reference: 8949893.
1995 Boulton, M.I., Haley, C.S., Springbett, A.J., Webb, R. :
The effect of the Booroola (Fec(B)) gene on peripheral FSH concentrations and ovulation rates during oestrus, seasonal anoestrus and on FSH concentrations following ovariectomy in Scottish Blackface ewes Journal of Reproduction and Fertility 103:199-207, 1995. Pubmed reference: 7616490.
Fleming, J.S., Greenwood, P.J., Heath, D.A., Hudson, N.L., Lun, S., Shaw, L., Mcnatty, K.P. :
Expression of gonadotrophin subunit genes in sheep that were homozygous carriers and non-carriers of the Booroola fecundity gene Fec(B) Journal of Reproduction and Fertility 103:315-321, 1995. Pubmed reference: 7542345.
Gootwine, E., Bor, A., Brawtal, R., Zenou, A. :
Reproductive performance and milk production of the improved Awassi breed as compared with its crosses with the Booroola Merino Animal Science 60:109-115, 1995.
Isaacs, K.L., Mcnatty, K.P., Condell, L., Shaw, L., Heath, D.A., Hudson, N.L., Littlejohn, R.P., Mcleod, B.J. :
Plasma FSH, LH and immunoreactive inhibin concentrations in FecB(B)/FecB(B) and FecB(+)/FecB(+) Booroola ewes and rams from birth to 12 months of age Journal of Reproduction and Fertility 103:89-97, 1995. Pubmed reference: 7707304.
McNatty, K.P., Smith, P., Hudson, N.L., Heath, D.A., Tisdall, D.J., WSO, Brawtal, R. :
Development of the sheep ovary during fetal and early neonatal life and the effect of fecundity genes Journal of Reproduction and Fertility Suppl. 49:123-135, 1995.
Montgomery, G.W., Penty, J.M., Lord, E.A., Brooks, J., Mcneilly, A.S. :
The gonadotrophin-releasing hormone receptor maps to sheep Chromosome 6 outside of the region of the FecB locus Mammalian Genome 6:436-438, 1995. Pubmed reference: 7647469.
Montgomery, G.W., Penty, J.M., Lord, E.A., Broom, M.F. :
The search for the Booroola (FecB) mutation Journal of Reproduction and Fertility :113-121, 1995. Pubmed reference: 7623306.
Moore, L.G., Mcnatty, K.P., Isaacs, K.L., Lun, S., Chie, W.N., Mcnatty, S., Hudson, N.L. :
Pituitary and plasma levels of growth hormone in Booroola sheep that are either homozygous carriers or non-carriers of the FecB(B) fecundity gene Journal of Endocrinology 147:217-223, 1995. Pubmed reference: 7490551.
Phillips, D.J., Moore, L.G., Hudson, N.L., Lun, S., Mcnatty, K.P. :
Effects of ovariectomy and FecB(B) genotype on the median charge and circulating half-life of pituitary FSH isoforms of ewes Journal of Reproduction and Fertility 104:27-31, 1995. Pubmed reference: 7636801.
Souza, C.J.H., Chagas, L.M., Moraes, J.C.F. :
The influence of the prolificacy gene Fec B on the reproductive biology of 3/4 Romney Marsh x 1/4 Merino Booroola ewes Revista Brasileira de Genetica 18:121-124, 1995.
Yamin, M., Payne, G., Blackshaw, J.K. :
The time of birth and the choice of birth sites by booroola merino ewes and angora goats Applied Animal Behaviour Science 45:89-96, 1995.
1994 Henkes, L.E., Weimer, T.A., Moraes, J.C.F. :
Genetic Markers and the Fertility Gene (Fec(B) in a 3/4 Romney-Marsh X 1/4 Merino-Booroola Flock Small Ruminant Research 14:55-59, 1994.
Lanneluc, I., Drinkwater, R.D., Elsen, J.M., Hetzel, D.J.S., Nguyen, T.C., Piper, L.R., Thimonier, J., Harrison, B., Gellin, J. :
Genetic Markers for the Booroola Fecundity (Fec) Gene in Sheep Mammalian Genome 5:26-33, 1994. Pubmed reference: 8111125.
Mcdonough, P.G. :
The Fecundity Gene for Sheep and Man Fertility and Sterility 61:191-192, 1994.
Mcnatty, K.P., Hudson, N.L., Shaw, L., Moore, L. :
Plasma concentrations of FSH, LH, thyroid-stimulating hormone and growth hormone after exogenous stimulation with GnRH, TRH and GHRH in Booroola ewes that are homozygous carriers or non- carriers of the Fec(B) gene Journal of Reproduction and Fertility 102:177-183, 1994. Pubmed reference: 7799311.
Meyer, H.H., Baker, R.L., Harvey, T.G., Hickey, S.M. :
Effects of Booroola Merino Breeding and the Fec(B) Gene on Performance of Crosses with Longwool Breeds .2. Effects on Reproductive Performance and Weight of Lamb Weaned by Young Ewes Livestock Production Science 39:191-200, 1994.
Meyer, H.H., Bigham, M.L., Baker, R.L., Harvey, T.G., Hickey, S.M. :
Effects of Booroola Merino Breeding and the Fec(B) Gene on Performance of Crosses with Longwool Breeds .1. Effects on Growth, Onset of Puberty, Wool Production and Wool Traits Livestock Production Science 39:183-190, 1994.
Meyer, H.H., Piper, L.R., Bindon, B.M., Woolaston, R.R. :
Litter Size and Uterine Efficiency of Booroola Merinos, Control Merinos and Their Crosses with Border Leicester and Dorset Livestock Production Science 38:217-223, 1994.
Montgomery, G.W., Lord, E.A., Penty, J.M., Dodds, K.G., Broad, T.E., Cambridge, L., Sunden, S.L.F., Stone, R.T., Crawford, A.M. :
The booroola fecundity (FecB) gene maps to sheep chromosome 6 Genomics 22:148-153, 1994. Pubmed reference: 7959761. DOI: 10.1006/geno.1994.1355.
Olive, D.L. :
The Fecundity Gene for Sheep and Man Fertility and Sterility 61:189-190, 1994. Pubmed reference: 8293839.
Smith, P., Brawtal, R., Corrigan, K., Hudson, N.L., Heath, D.A., Mcnatty, K.P. :
Ontogeny of ovarian follicle development in Booroola sheep fetuses that are homozygous carriers or non-carriers of the Fec(B) gene Journal of Reproduction and Fertility 100:485-490, 1994. Pubmed reference: 8021867.
Souza, C.J.H., Moraes, J.C.F., Chagas, L.M. :
Effect of the Booroola Gene on Time of Ovulation and Ovulatory Dynamics Animal Reproduction Science 37:7-13, 1994.
Stokman, P.G.W. :
The Fecundity Gene for Sheep and Man - Reply Fertility and Sterility 61:190-191, 1994.
Veress, L., Horvath, V. :
Booroola Merino Sheep and Its Possibilities of Utilization in Hungary Magyar Allatorvosok Lapja 49:80-86, 1994.
1993 Brawtal, R., Bor, A., Gootwine, E. :
Plasma Immunoreactive Inhibin and FSH in Prepubertal Assaf and Booroola-Assaf Ewe Lambs Domestic Animal Endocrinology 10:87-94, 1993. Pubmed reference: 8325013.
Bunge, R., Thomas, D.L., Nash, T.G. :
Performance of Hair Breeds and Prolific Wool Breeds of Sheep in Southern Illinois - Lamb Production of F1 Ewe Lambs Journal of Animal Science 71:2012-2017, 1993. Pubmed reference: 8376223.
Crawford, A.M., Swarbrick, P.A., Buchanan, F.C., Dodds, K.G. :
DNA Fingerprinting Analysis of Booroola Pedigrees - A Search for Linkage to the Booroola Gene Theoretical and Applied Genetics 87:271-277, 1993.
Gootwine, E., Bor, A., Brawtal, R., Zenou, A. :
Inheritance of Birthweight and Growth Traits in Crosses Between the Booroola Merino and Assaf Sheep Breeds Livestock Production Science 33:119-126, 1993.
Gootwine, E., Brawtal, R., Shalhevet, D., Bor, A., Zenou, A. :
Reproductive Performance of Assaf and Booroola-Assaf Crossbred Ewes and Its Association with Plasma FSH Levels and Induced Ovulation Rate Measured at Prepuberty Animal Reproduction Science 31:69-81, 1993.
Kleemann, D.O., Walker, S.K., Walkley, J.R.W., Ponzoni, R.W., Smith, D.H., Grimson, R.J., Seamark, R.F. :
Effect of Nutrition During Pregnancy on Birth Weight and Lamb Survival in Fec(B) Booroola South Australian Merino Ewes Animal Reproduction Science 31:213-224, 1993.
Kleemann, D.O., Walker, S.K., Walkley, J.R.W., Ponzoni, R.W., Smith, D.H., Grimson, R.J., Seamark, R.F. :
Effect of Nutrition During Pregnancy on Fetal Growth and Survival in Fec(B) Booroola-X South Australian Merino Ewes Theriogenology 39:623-630, 1993.
Mcnatty, K.P., Hudson, N.L., Lun, S., Heath, D.A., Shaw, L., Condell, L., Phillips, D.J., Clarke, I.J. :
Gonadotrophin-Releasing Hormone and the Control of Ovulation Rate by the Fec(B) Gene in Booroola Ewes Journal of Reproduction and Fertility 98:97-105, 1993. Pubmed reference: 8345485.
Montgomery, G.W., Crawford, A.M., Penty, J.M., Dodds, K.G., Ede, A.J., Henry, H.M., Pierson, C.A., Lord, E.A., Galloway, S.M., Schmack, A.E., Sise, J.A., Swarbrick, P.A., Hanrahan, V., Buchanan, F.C., Hill, D.F. :
The Ovine Booroola Fecundity Gene (FecB) Is Linked to Markers from a Region of Human Chromosome-4q Nature Genetics 4:410-414, 1993. Pubmed reference: 8401591. DOI: 10.1038/ng0893-410.
Phillips, D.J., Hudson, N.L., Mcnatty, K.P. :
Effects of Ovariectomy and Genotype on Bioactive FSH in Plasma and Pituitary of Booroola Ewes Journal of Reproduction and Fertility 98:559-565, 1993. Pubmed reference: 8410825.
Smith, P., O, W.S., Hudson, N.L., Shaw, L., Heath, D.A., Condell, L., Phillips, D.J., Mcnatty, K.P. :
Effects of the Booroola Gene (FecB) on Body Weight, Ovarian Development and Hormone Concentrations During Fetal Life Journal of Reproduction and Fertility 98:41-54, 1993. Pubmed reference: 8345478.
1992 Bor, A., Brawtal, R., Gootwine, E. :
Monitoring Ovarian Response of Booroola Assaf Ewe Lambs to PMSG, Using Ultrasonography and Serum Estradiol Theriogenology 38:645-652, 1992.
Fleming, J.S., Greenwood, P.J., Chen, C.L.C. :
Expression of the Clusterin Gene in the Tissues of Booroola Sheep Which Were Homozygotes or Non-Carriers of the Fecundity Gene FecB Journal of Molecular Endocrinology 9:207-211, 1992. Pubmed reference: 1476607.
Fleming, J.S., Tisdall, D.J., Greenwood, P.J., Hudson, N.L., Heath, D.A., Mcnatty, K.P. :
Expression of the Genes for alpha-Inhibin, betaA Inhibin and Follistatin in the Ovaries of Booroola Ewes Which Were Homozygotes or Non-Carriers of the Fecundity Gene Fec(B) Journal of Molecular Endocrinology 8:265-273, 1992. Pubmed reference: 1378743.
Fogarty, N.M., Hall, D.G., Atkinson, W.R. :
Management of Highly Fecund Ewe Types and Their Lambs for 8- Monthly Lambing .2. Effect of Weaning Age and Sex on Lamb Growth and Carcass Traits Australian Journal of Experimental Agriculture 32:1031-1036, 1992.
Fogarty, N.M., Hall, D.G., Dawe, S.T., Atkinson, W., Allan, C. :
Management of Highly Fecund Ewe Types and Their Lambs for 8- Monthly Lambing .1. Effect of Lamb Weaning Age on Ewe Reproductive Activity in Spring Australian Journal of Experimental Agriculture 32:421-428, 1992.
Gootwine, E., Bor, A., Shalhevet, D., Zenou, A., Brawtal, R. :
Differential Pituitary Response to GnRH in Pregnant Booroola- Assaf and Assaf Ewes Reproduction Fertility and Development 4:231-237, 1992.
Hall, D.G., Piper, L.R., Egan, A.R., Bindon, B.M. :
Lamb and Milk Production from Booroola Ewes Supplemented in Late Pregnancy Australian Journal of Experimental Agriculture 32:587-593, 1992.
Mcnatty, K.P., Heath, D.A., Hudson, N.L., Ball, K., Condell, L. :
Concentrations of Immunoreactive Inhibin in Ovarian and Peripheral Venous Plasma and Follicular Fluid of Booroola Ewes That Are Homozygous Carriers or Non-Carriers of the FecB Gene Journal of Reproduction & Fertility 95:489-502, 1992. Pubmed reference: 1518004.
Montgomery, G.W., Penty, J.M., Sise, J.A., Tou, H.M. :
Genes Encoding the alpha-Chains and beta-Chains of Follicle- Stimulating Hormone Are Not Sites for the Booroola (Fec(B)) Mutation in Sheep Journal of Reproduction & Fertility 95:895-901, 1992. Pubmed reference: 1383540.
Nguyen, T.C., Elsen, J.M., Cullen, P.R. :
Absence of Evidence for Linkage Between Booroola Gene and Genetic Markers at 11 Sheep Blood Polymorphic Loci Animal Genetics 23:525-527, 1992. Pubmed reference: 1492703.
Pollard, J.C. :
Effects of Litter Size on the Vocal Behaviour of Ewes Applied Animal Behaviour Science 34:75-84, 1992.
Price, C.A., Hudson, N.L., Mcnatty, K.P. :
Effect of Testosterone and Bovine Follicular Fluid on Concentrations of Luteinizing Hormone and Follicle- Stimulating Hormone in Plasma of Castrated Rams That Are Homozygous Carriers or Non-Carriers of the Booroola Fecundity Gene Journal of Reproduction & Fertility 95:947-957, 1992. Pubmed reference: 1404107.
Suss, R., Wolf, M., Richter, A. :
Results Recorded from Use of Imported Deep-Frozen Booroola Sperma - Brief Communication Monatshefte Fur Veterinarmedizin 47:337-339, 1992.
Tate, M.L., Manly, H.C., Dodds, K.G., Montgomery, G.W. :
Genetic Linkage Analysis Between Protein Polymorphisms and the Fec(B) Major Gene in Sheep Animal Genetics 23:417-424, 1992. Pubmed reference: 1416247.
1991 Henderson, K.M., Mcnatty, K.P., Wards, R.L., Heath, D.A., Lun, S. :
Inhibin Production Invitro by Granulosa Cells from Booroola Ewes Which Were Either Homozygous or Non-Carriers of a Fecundity Gene Influencing Their Ovulation Rate Journal of Reproduction & Fertility 92:147-157, 1991. Pubmed reference: 2056486.
Isaacs, K.L., Owens, J.L., Littlejohn, R.P., Johnstone, P.D., Fennessy, P.F. :
Influence of Maternal Liveweight on Reproductive Performance and Wool Production of Heterozygous Booroola Merinoxcoopworth (Fecb Fec+) and Merinoxcoopworth Ewes New Zealand Journal of Agricultural Research 34:55-67, 1991.
Kleemann, D.O., Walker, S.K., Grimson, R.J., Smith, D.H., Grosser, T.I., Seamark, R.F. :
Exogenous Progesterone and Embryo Survival in Booroola-Cross Ewes Reproduction Fertility and Development 3:71-77, 1991.
Kleemann, D.O., Walkley, J.R.W., Ponzoni, R.W., Smith, D.H., Grimson, R.J., Seamark, R.F. :
Effect of Premating Nutrition on Reproductive Performance of Booroola Merino X South Australian Merino Ewes Animal Reproduction Science 26:269-279, 1991.
Moraes, J.C.F., Deoliveira, N.M., Selaivevillarroel, A. :
Evaluation of Three Criteria Used to Identify F-Gene Carriers in a Romney-X Merino Booroola Sheep Flock in South Brazil Revista Brasileira de Genetica 14:983-989, 1991.
Peeters, R., Michels, H., Vanmontfort, D., Decuypere, E., Robijns, L., Vanisterdael, J. :
The Particular Reproductive Biology of F-Gene Carrying Sheep, with Production and Endocrine Parameters Being Used as Criterions for Identification, Prediction and Selection Landbouwtijdschrift - Revue de L Agriculture 44:1199-1212, 1991.
Price, C.A., Hudson, N.L., Mcnatty, K.P. :
Plasma LH, FSH and Testosterone Concentrations in Adult Rams Which Were Homozygous Carriers or Non-Carriers of the Booroola Fecundity Gene Journal of Reproduction & Fertility 91:267-275, 1991. Pubmed reference: 1899887.
Price, C.A., Hudson, N.L., Mcnatty, K.P. :
Effect of Castration on Plasma Concentrations of Luteinizing Hormone and Follicle-Stimulating Hormone in Adult Merino Rams Which Were Homozygous Carriers or Non-Carriers of the Booroola Fecundity Gene Journal of Reproduction & Fertility 93:211-219, 1991. Pubmed reference: 1920292.
Rodgers, R.J. :
Cloning of the Inhibin/Activin beta Subunit Gene from the Booroola Merino Sheep Journal of Molecular Endocrinology 6:87-93, 1991. Pubmed reference: 2015059.
Young, L.D., Dickerson, G.E. :
Comparison of Booroola Merino and Finnsheep - Effects on Productivity of Mates and Performance of Crossbred Lambs Journal of Animal Science 69:1899-1911, 1991. Pubmed reference: 2066300.
1990 Castonguay, F., Dufour, J.J., Minvielle, F., Estrada, R. :
Follicular Dynamics and Dominance in Booroola X Finnish Landrace and Booroola X Suffolk Ewes Heterozygous for the F- Gene Journal of Reproduction & Fertility 89:193-203, 1990. Pubmed reference: 2374114.
Castonguay, F., Minvielle, F., Dufour, J.J. :
Reproductive Performance of Booroola X Finnish Landrace and Booroola X Suffolk Ewe Lambs, Heterozygous for the F-Gene, and Growth Traits of Their 3-Way Cross Lambs Canadian Journal of Animal Science 70:55-65, 1990.
Cribiu, E.P., Durand, V., Chaffaux, S. :
Frequency of the Freemartinism in Booroola-Merino-Darles Recueil de Medecine Veterinaire 166:919-922, 1990.
Fleming, J.S., Lun, S., Smith, P., Mcnatty, K.P. :
Pituitary Binding Sites for Gonadotrophin-Releasing Hormone in Booroola Merino Ewes Which Were Non-Carriers or Homozygotes of the Fecundity Gene-F Journal of Neuroendocrinology 2:601-604, 1990.
Kleemann, D.O., Walker, S.K., Walkley, J.R.W., Smith, D.H., Grimson, R.J., Seamark, R.F. :
Fertilization and Embryo Loss in Booroola Merino-X South Australian Merino Ewes - Effect of the F Gene Theriogenology 33:487-498, 1990.
Kleemann, D.O., Walker, S.K., Walkley, J.R.W., Smith, D.H., Ponzoni, R.W., Seamark, R.F. :
Factors Influencing Lamb Survival in a High Fecundity Booroola Merino-X South Australian Merino Flock Theriogenology 33:965-976, 1990.
Mcnatty, K.P., Heath, D.A., Hudson, N., Clarke, I.J. :
Effect of Long-Term Hypophysectomy on Ovarian Follicle Populations and Gonadotrophin-Induced Adenosine Cyclic 3',5'- Monophosphate Output by Follicles from Booroola Ewes with or Without the F-Gene Journal of Reproduction & Fertility 90:515-522, 1990. Pubmed reference: 2174458.
Mcnatty, K.P., Lun, S., Hudson, N.L., Forbes, S. :
Effects of Follicle Stimulating Hormone, Cholera Toxin, Pertussis Toxin and Forskolin on Adenosine Cyclic 3',5'- Monophosphate Output by Granulosa Cells from Booroola Ewes with or Without the F-Gene Journal of Reproduction & Fertility 89:553-563, 1990. Pubmed reference: 2169531.
Montgomery, G.W., Sise, J.A., Greenwood, P.J., Fleming, J.S. :
The Booroola F-Gene Mutation in Sheep Is Not Located Close to the FSH-Beta Gene Journal of Molecular Endocrinology 5:167-173, 1990. Pubmed reference: 1978999.
Niswender, G.D., Mcnatty, K.P., Smith, P., Niswender, K.D., Farin, C.E., Sawyer, H.R. :
Numbers of Steroidogenic Luteal Cells in Booroola Merino Ewes Journal of Reproduction & Fertility 90:185-190, 1990. Pubmed reference: 2231539.
Ritar, A.J., Williams, P.M., Omay, P.J., Gilbert, K.D., Bond, E.M., King, C.F. :
Growth and Carcass Characteristics of Male Crossbred Lambs from High Fecundity Booroola X Polwarth Ewes - Effects of Litter Size, Castration and Age Australian Journal of Experimental Agriculture 30:323-328, 1990.
1989 Brawtal, R., Gootwine, E. :
Pituitary Response to GnRH and Ovariectomy in Booroola-Awassi and Awassi Ewe Lambs Journal of Reproduction & Fertility 87:73-80, 1989. Pubmed reference: 2516136.
McNatty, K.P., Fisher, M., Collins, F., Hudson, N.L., Heath, D.A., Ball, K., Henderson, K.M. :
Differences in the plasma concentrations of FSH and LH in ovarectomized Booroola FF and ++ ewes Journal of Reproduction and Fertility 85:705-713, 1989. Pubmed reference: 2495362.
McNatty, K.P., Heath, D.A., Lun, S., Hudson, N.L. :
Adenosine 3prime,5prime-cyclic monophosphate phosphodiesterase activity in granulosa cells from Booroola * Romney ewes with and without the F gene Journal of Endocrinology 120:287-293, 1989. Pubmed reference: 2538535.
McNatty, K.P., Lun, S., Heath, D.A., Hudson, N.L., O'Keefe, L.E., Henderson, K.M. :
Binding characteristics of (125)I-labelled human FSH to granulosa cells from Booroola ewes which were homozygous, heterozygous or non-carriers of a major gene(s) influencing their ovulation rate Journal of Reproduction and Fertility 86:27-38, 1989. Pubmed reference: 2502619.
Montgomery, G.W., Scott, I.C., Littlejohn, R.P., Davis, G.H., Peterson, A.J. :
Concentrations of FSH Are Elevated in New-Born Ewe Lambs Carrying the Booroola F-Gene But Not in Lambs from a Prolific Romney Strain Reproduction Fertility and Development 1:299-307, 1989.
Urashima, T., Saito, T., Nishimura, J., Ariga, H. :
New Galactosyllactose Containing Alpha-Glycosidic Linkage Isolated from Ovine (Booroola-Dorset) Colostrum Biochimica et Biophysica Acta 992:375-378, 1989. Pubmed reference: 2775793.
1988 Burditt, L.G., Zavy, M.T., Buchanan, D.S. :
Litter size, birth weight and weaning weight in Dorset, Finnish Landrace or Booroola Merino sired lambs Animal Science Research Report, Oklahoma Agricultural Experiment Station :14-16, 1988.
Fry, R.C., Clarke, I.J., Cummins, J.T., Bindon, B.M., Piper, L.R., Cahill, L.P. :
Induction of ovulation in chronically hypophysectomized Booroola ewes Journal of Reproduction and Fertility 82:711-715, 1988. Pubmed reference: 3361505.
Gale, J.S., Smith, P., Truman, P., McNatty, K.P. :
Immunoassay of gonadotropin-releasing hormone in brain tissue of Booroola Merino ewes Journal of Reproduction and Fertility 82:581-586, 1988. Pubmed reference: 3283345.
Kleeman, D.O., Walker, S.K., Walkley, J.R.W., Smith, D.H., Grimson, R.J., McCloud, P.I., Seamark, R.F., Rogan, I.M. :
Causes of lamb mortality in a Booroola X South Australian Merino flock heterozygous for the high fecundity gene :682-684, 1988.
Owen, J.B. :
Breeding for fecundity in sheep Veterinary Record 123:308-310, 1988. Pubmed reference: 3195010.
Piper, L.R., Bindon, B.M. :
The genetics and endocrinology of the Booroola sheep F gene :270-282, 1988.
Piper, L.R., Bindon, B.M., Davis, G.H., Elsen, J.M. :
Control of litter size: major genes and industry utilization of the Booroola F gene :589-609, 1988.
Willingham, T., Shelton, M., Lupton, C. :
The influence of introducing the Booroola Merino genotype to Rambouillet flocks on reproduction and fleece traits in comparison with other selected breed crosses SID Research Journal, Sheep Industry Development 6:1-5, 1988.
Young, L.D., Dickerson, G.E. :
Performance of Booroola Merino and Finnsheep crossbred lambs and ewes Journal of Agricultural Science in Finland [Proceedings of a Joint Special Symposium of the Commissions on Animal Genetics and on Sheep and Goats, EAAP, Kelsinki, Finland, 1 July 1988] 60:492-499, 1988.
1987 Bindon, B.M., Piper, L.R. :
Physiological aspects of selection for increased reproductive rate :243-257, 1987.
Davis, G.H., Armstrong, J.R., Shackell, G.H. :
Booroola breeding :140-141, 1987.
Fogarty, N.M., Hall, D.G. :
Lifetime reproduction and wool production of Trangie Fertility Merino X Dorset and Booroola X Dorset ewes :283-288, 1987.
Fry, R.C., Cahill, L.P., Cummins, J.T., Bindon, B.M., Piper, L.R., Clarke, I.J. :
The half-life of follicle-stimulating hormone in ovary-intact and ovariectomized Booroola and control Merino ewes Journal of Reproduction and Fertility 81:611-615, 1987. Pubmed reference: 3123660.
Hanrahan, J.P. :
Genetic variation in ovulation rate in sheep :37-46, 1987.
Henderson, K.M., McNatty, K.P., O'Keefe, L.E., Lun, S., Heath, D.A., Prisk, M.D. :
Differences in gonadotrophin-stimulated cyclic AMP production by granulosa cells from Booroola X Merino ewes which were homozygous, heterozygous or non-carriers of a fecundity gene influencing their ovulation rate Journal of Reproduction and Fertility 81:395-402, 1987. Pubmed reference: 2828609.
King, C.F. :
Regulation of the Booroola gene by prejoining nutrition :293-296, 1987.
Kleemann, D.O., Walker, S.K., Walkley, J.R.W., Ponzoni, R.W., Smith, D.H., Grimson, R.J., Seamark, R.F. :
Effect of premating nutrition on ovulation rate, litter size and lamb survival in F+ Booroola X South Australian Merino ewes :289-292, 1987.
Martin, G.B., Sutherland, S.R.D., Lindsay, D.R. :
Effects of nutritional supplements on testicular size and the secretion of LH and testosterone in Merino and Booroola rams Animal Reproduction Science 12:267-281, 1987.
McNatty, K.P., Henderson, K.M. :
Gonadotrophins, fecundity genes and ovarian follicular function Journal of Steroid Biochemistry 27:365-373, 1987. Pubmed reference: 2826892.
McNatty, K.P., Hudson, N., Henderson, K.M., Gibb, M., Morrison, L., Ball, K., Smith, P. :
Differences in gonadotrophin concentrations and pituitary responsiveness to GnRH between Booroola ewes which were homozygous (FF), heterozygous (F+) and non-carriers (++) of a major gene influencing their ovulation rate Journal of Reproduction and Fertility 80:577-588, 1987. Pubmed reference: 3116233.
McNatty, K.P., Hudson, N., Smith, P., Ball, K. :
Why are Booroola ewes so efficient at producing three or more lambs? :115-116, 1987.
McNatty, K.P., Lun, S., Heath, D.A., O'Keefe, L.E. :
Ovarian follicular activity in Booroola lambs with and without a fecundity gene Journal of Reproduction and Fertility 79:57-66, 1987. Pubmed reference: 3029369.
Moore, R.W., Lynch, P.R., Miller, C.M. :
The effect of the F gene on conception rate and sperm characteristics :79 only, 1987.
Nitter, G. :
Economic response to increasing genetic potential for reproductive performance :271-280, 1987.
Piper, L.R., Bindon, B.M. :
Industry utilisation of the Booroola Merino in Australia :279-282, 1987.
Shackell, G.H. :
Transference of Booroola embryos into Coopworth ewes :141-142, 1987.
Veress, L., Vegh, J., Horvath, V. :
[Breeding Booroola Merino sheep in Hungary] Allattenyesztes es Takarmanyozas 36:53-61, 1987.
Young, L.D., Dickerson, G.E. :
Performance of progeny of Booroola Merino and Finnsheep rams Sheep Research Program Progress Report, Roman L. Hruska US Meat Animal Research Center :4-5, 1987.
Young, L.D., Dickerson, G.E. :
History and current status of Booroola Merino flock at MARC Sheep Research Program Progress Report, Roman L. Hruska US Meat Animal Research Center :3 only, 1987.
1986 Baker, R.L., Clarke, J.N., Harvey, T.G., Meyer, H.H. :
Inheritance of foot and jaw abnormalities in sheep Proceedings of the New Zealand Society of Animal Production 46:93-100, 1986.
Bindon, B.M., Piper, L. :
The reproductive biology of prolific sheep breeds Oxford Reviews of Reproductive Biology 8:414-451, 1986. Pubmed reference: 3540808.
Bindon, BM., Piper, LR. :
Booroola (F) gene: major gene affecting ovine ovarian function. Basic Life Sci 37:67-93, 1986. Pubmed reference: 3707496.
Dratch, P.A., Allison, A.J., Williams, T.L., Kyle, B., Wyllie, J.G., Littlejohn, R.P. :
Haemoglobin type and prolificacy in Booroola sheep Proceedings of the New Zealand Society of Animal Production 46:237-240, 1986.
Fernandez Abella, D., Blanc, M.R., Cognie, Y. :
[Effect of the Booroola gene on reproductive traits] Revista de la Asociacion Interprofesional para el Desarrollo Agrario 17:3-22, 1986.
McNatty, K.P., Lun, S., Heat, D., Hudson, N., McDiarmid, J., Ball, K., Smith, P., Henderson, K.M. :
Ovarian follicular development in Booroola ewe lambs and in highly fecund Booroola ewes Proceedings of the New Zealand Society of Animal Production 46:241-244, 1986.
1985 Davis, G.H. :
Use of imported genetic material to increase prolificacy in sheep In "Genetics of Reproduction in Sheep", Eds Land RB & Robinson DW. London: Butterworths. :45-54, 1985.
Davis, G.H., Johnstone, P.D. :
Ovulation response to pregnant mares' serum gonadotrophin in prepubertal ewe lambs of different Booroola genotypes Animal Reproduction Science 9:145-151, 1985.
Piper, L.R., Land, R.B., Bindon, B.M., Robinson, D.W., Davis, G.W. :
The single gene inheritance of the prolificacy of the Booroola Merino In "Genetics of Reproduction in Sheep", Eds Land RB & Robinson DW. London: Butterworths. :115-125, 1985.
Ponzoni, R.W., Fleet, M.R., Walkley, J.R.W., Walker, S.K. :
A note on the effect of the F gene on wool production and live weight of Booroola X South Australian Merino rams Animal Production 40:367-369, 1985.
Walker, S.K., Ponzoni, R.W., Walkley, J.R.W., Morbey, A.S.C. :
The effect of the F gene on male reproductive traits in Booroola X South Australian Merino rams Animal Reproduction Science 9:137-144, 1985.
1984 Bindon, B.M., Piper, L.R., Thimonier, J. :
Preovulatory LH characteristics and time of ovulation in the prolific Booroola Merino ewe Journal of Reproduction and Fertility 71:519-523, 1984. Pubmed reference: 6540311.
Meyer, H.H., Kirton, A.H. :
Growth and carcass characteristics of Romney, Perendale, and their Booroola Merino crossbred ram lambs New Zealand Journal of Agricultural Research 27:167-172, 1984.
Owens, J.L., Bindon, B.M., Edey, T.N., Piper, L.R. :
Effect of litter size on blood haematocrit and liveweight in Booroola Merino and Merino ewes during pregnancy and the post-partum period Theriogenology 22:579-586, 1984.
Robertson, D.M., Ellis, S., Foulds, L.M., Findlay, J.K., Bindon, B.M. :
Pituitary gonadotrophins in Booroola and control Merino sheep Journal of Reproduction and Fertility 71:189-197, 1984. Pubmed reference: 6427454.
1983 Cummins, LJ., O'Shea, T., Bindon, BM., Lee, VW., Findlay, JK. :
Ovarian inhibin content and sensitivity to inhibin in Booroola and control strain Merino ewes. J Reprod Fertil 67:1-7, 1983. Pubmed reference: 6401808.
Davis, G.H. :
Introduction and management of the Booroola gene in commercial sheep flocks New Zealand Agricultural Science 17:269-271, 1983.
Davis, G.H., Kelly, R.W. :
Segregation of a major gene influencing ovulation rate in progeny of Booroola sheep in commercial and research flocks. New Zealand Journal of Agricultural Research 43:197-199, 1983.
Davis, G.H., Meyer, H.H. :
What Booroolas have to offer Proceedings of the Ruakura Farmers' Conference 35:21-23, 1983.
Kelly, R.W., Owens, J.L., Crosbie, S.F., McNatty, K.P., Hudson, N. :
Influence of Booroola Merino genotype on the responsiveness of ewes to pregnant mares serum gonadotrophin, luteal tissue weights and peripheral progesterone concentrations Animal Reproduction Science 6:199-207, 1983.
King, J.W.B. :
The Booroola Merino: in pursuit of fecundity Span 26:82-83, 1983.
Montgomery, G.W., Bray, A.R., Kelly, R.W. :
Ovulation rates of first cross Booroola compared with local breed ewes following differential feeding Animal Reproduction Science 6:209-215, 1983.
Piper, L.R., Bindon, B.M. :
The Booroola merino and the performance of medium non-Peppin crosses at Armidale Wool Technology and Sheep Breeding 31:14-19, 1983.
Purvis, I.W., Piper, L.R., Bindon, B.M., Edey, T.N., Curtis, Y.M., Nethery, R.D. :
Further studies of testis size in crossbred ewes Proceedings of the Fifteenth Annual Conference of the Australian Society for Reproductive Biology, Canberra, September 4-7, 1983 :34 only, 1983.
Tassell, RJ., Kennedy, JP., Bindon, BM., Piper, LR. :
Ovarian follicles of new-born Merino lambs from genetic lines which differ in fecundity. Aust J Biol Sci 36:351-5, 1983. Pubmed reference: 6362634.
1982 Davis, G.H., Montgomery, G.W., Allison, A.J., Kelly, R.W., Bray, A.R. :
Segregation of a major gene influencing fecundity in progeny of Booroola sheep New Zealand Journal of Agricultural Research 25:525–529, 1982.
Piper, L.R., Bindon, B.M. :
Genetic segregation for fecundity in Booroola Merino sheep Proceedings of the World Congress on Sheep and Beef Cattle Breeding 1:394-400, 1982.
Piper, L.R., Bindon, B.M. :
The Booroola Merino and performance of non-Peppin crosses at Armidale. The Booroola Merino (eds. L.R. Piper et al.), CSIRO, Melbourne :9-20, 1982.
1980 Hawker, H., Davis, G.H., Allison, A.J. :
Wool production and characteristics of Merino and longwool ewes and their respective Booroola crosses Proceedings of the New Zealand Society of Animal production 40:205-208, 1980.

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