OMIA:000425-9940 : Haemonchus contortus, resistance to in Ovis aries (sheep)
Categories: Immune system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Species-specific name: Golden ram effect
Species-specific description: In a large-scale investigation of the quantitative genetics of resistance and resiliance to Haemonchus contortus in Merino sheep, Albers et al. (1987) observed one 'outlier' sire (dubbed the "golden ram") whose progeny exhibited extremely high resistance. The evidence justified a tentative conclusion that this sire was carrying a major gene for resistance. Unfortunately, such a gene failed to materialise in studies of subsequent generations.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Okino, C.H., Niciura, S.C.M., Giaretta, P.R., Melito, G.R., Kapritchkoff, R.T.I., Santos, I.B.D., Rech, R.R., Minho, A.P., Esteves, S.N., Chagas, A.C.S. :|
|Enhanced mucosal response in sheep harbouring βA beta-globin against haemonchosis. Parasite Immunol :e13003, 2023. Pubmed reference: 37400087. DOI: 10.1111/pim.13003.|
|Werne, S., Schwarz, K., Thüer, S., Bapst, B. :|
|Breeding options for nematode resistance in Lacaune dairy sheep. Animal 17:100772, 2023. Pubmed reference: 37031576. DOI: 10.1016/j.animal.2023.100772.|
|1987||Albers, G.A.A., Gray, G.D., Piper, L.R., Barker, J.S.F., Le Jambre, L.F., Barger, I.A. :|
|The genetics of resistance and resilience to Haemonchus contortus infection in young Merino sheep International Journal for Parasitology 17:1355-1363, 1987. Pubmed reference: 3429127.|
|Gray, G.D. :|
|Genetic resistance to haemonchosis in sheep Parasitology Today 3:253-255, 1987.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 21 May 2012
- Changed by Frank Nicholas on 20 Aug 2020
- Changed by Imke Tammen2 on 23 Apr 2023