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OMIA:000425-9940 : Haemonchus contortus, resistance to in Ovis aries (sheep)

Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific name: Golden ram effect

Species-specific description: In a large-scale investigation of the quantitative genetics of resistance and resiliance to Haemonchus contortus in Merino sheep, Albers et al. (1987) observed one 'outlier' sire (dubbed the "golden ram") whose progeny exhibited extremely high resistance. The evidence justified a tentative conclusion that this sire was carrying a major gene for resistance. Unfortunately, such a gene failed to materialise in studies of subsequent generations.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000425-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Okino, C.H., Niciura, S.C.M., Giaretta, P.R., Melito, G.R., Kapritchkoff, R.T.I., Santos, I.B.D., Rech, R.R., Minho, A.P., Esteves, S.N., Chagas, A.C.S. :
Enhanced mucosal response in sheep harbouring βA beta-globin against haemonchosis. Parasite Immunol :e13003, 2023. Pubmed reference: 37400087. DOI: 10.1111/pim.13003.
Werne, S., Schwarz, K., Thüer, S., Bapst, B. :
Breeding options for nematode resistance in Lacaune dairy sheep. Animal 17:100772, 2023. Pubmed reference: 37031576. DOI: 10.1016/j.animal.2023.100772.
1987 Albers, G.A.A., Gray, G.D., Piper, L.R., Barker, J.S.F., Le Jambre, L.F., Barger, I.A. :
The genetics of resistance and resilience to Haemonchus contortus infection in young Merino sheep International Journal for Parasitology 17:1355-1363, 1987. Pubmed reference: 3429127.
Gray, G.D. :
Genetic resistance to haemonchosis in sheep Parasitology Today 3:253-255, 1987.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 21 May 2012
  • Changed by Frank Nicholas on 20 Aug 2020
  • Changed by Imke Tammen2 on 23 Apr 2023