OMIA:000453-9615 : Hepatic encephalopathy in Canis lupus familiaris (dog)

In other species: domestic cat , sheep

Categories: Nervous system phene

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A degenerative disease of the brain induced by a failure of the liver to metabolise ammonia. Clinical signs include excitability, tremor, compulsive walking, head pressing, and apparent blindness, followed by coma and convulsions.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000453-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2016 Lidbury, J.A., Cook, A.K., Steiner, J.M. :
Hepatic encephalopathy in dogs and cats. J Vet Emerg Crit Care (San Antonio) , 2016. Pubmed reference: 27060899. DOI: 10.1111/vec.12473.
1995 Anon. :
Hepatic encephalopathy Tijdschrift Voor Diergeneeskunde 120:344-345, 1995. Pubmed reference: 7785046.
Maddison, J.E., Watson, W.E.J., Johnston, G.A.R. :
L-glutamate and gamma-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy Metabolic Brain Disease 10:135-141, 1995. Pubmed reference: 7675012.
Rothuizen, J., Biewenga, W.J., Mol, J.A. :
Chronic glucocorticoid excess and impaired osmoregulation of vasopressin release in dogs with hepatic encephalopathy Domestic Animal Endocrinology 12:13-24, 1995. Pubmed reference: 7621676.
1992 Maddison, J.E., Watson, W.E.J., Johnston, G.A.R. :
CNQX Binding to Non-NMDA Glutamate Receptors in Canine Cerebro-Cortical Crude Synaptosomal Membranes - Pharmacological Characterization and Comparison of Binding Parameters in Dogs with Congenital Portosystemic Encephalopathy and Control Dogs Metabolic Brain Disease 7:35-44, 1992. Pubmed reference: 1376856.
Maddison, J.E. :
Hepatic Encephalopathy - Current Concepts of the Pathogenesis Journal of Veterinary Internal Medicine 6:341-353, 1992. Pubmed reference: 1362445.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005