OMIA:000453-9615 : Hepatic encephalopathy in Canis lupus familiaris (dog)

In other species: domestic cat , sheep

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A degenerative disease of the brain induced by a failure of the liver to metabolise ammonia. Clinical signs include excitability, tremor, compulsive walking, head pressing, and apparent blindness, followed by coma and convulsions.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000453-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2016 Lidbury, J.A., Cook, A.K., Steiner, J.M. :
Hepatic encephalopathy in dogs and cats. J Vet Emerg Crit Care (San Antonio) , 2016. Pubmed reference: 27060899. DOI: 10.1111/vec.12473.
1995 Anon. :
Hepatic encephalopathy Tijdschrift Voor Diergeneeskunde 120:344-345, 1995. Pubmed reference: 7785046.
Maddison, J.E., Watson, W.E.J., Johnston, G.A.R. :
L-glutamate and gamma-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy Metabolic Brain Disease 10:135-141, 1995. Pubmed reference: 7675012.
Rothuizen, J., Biewenga, W.J., Mol, J.A. :
Chronic glucocorticoid excess and impaired osmoregulation of vasopressin release in dogs with hepatic encephalopathy Domestic Animal Endocrinology 12:13-24, 1995. Pubmed reference: 7621676.
1992 Maddison, J.E., Watson, W.E.J., Johnston, G.A.R. :
CNQX Binding to Non-NMDA Glutamate Receptors in Canine Cerebro-Cortical Crude Synaptosomal Membranes - Pharmacological Characterization and Comparison of Binding Parameters in Dogs with Congenital Portosystemic Encephalopathy and Control Dogs Metabolic Brain Disease 7:35-44, 1992. Pubmed reference: 1376856.
Maddison, J.E. :
Hepatic Encephalopathy - Current Concepts of the Pathogenesis Journal of Veterinary Internal Medicine 6:341-353, 1992. Pubmed reference: 1362445.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005