OMIA:000485-9544 : Huntington disease in Macaca mulatta (Rhesus monkey) |
In other species: crab-eating macaque , pig , sheep
Categories: Nervous system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 143100 (trait) , 613004 (gene)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Disease-related: yes
Key variant known: no
Species-specific description:
Yang et al. (2008) developed "a transgenic model of HD in a rhesus macaque that expresses polyglutamine-expanded HTT". Resultant animals are genetically-modified organisms (GMO).
Khampang et al. (2021) "report a novel stem cell model that replicates genome instability and CAG repeat expansion in in vitro derived HD monkey spermatogenic cells."
Ryu et al. (2024) used CRISPR/Cas9 technology to introduce "an expanded CAG repeat into the HTT gene in rhesus macaque embryos. ... 15% of the embryos carried an expanded CAG repeat." (GMO)
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| HTT | huntingtin | Macaca mulatta | 5 | NC_041758.1 (3190699..3356988) | HTT | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000485-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Han, B., Liang, W., Li, X.J., Li, S., Yan, S., Tu, Z. : |
| Large animal models for Huntington's disease research. Zool Res 45:2095-8137(2024)02-0275-09:275-283, 2024. Pubmed reference: 38485497. DOI: 10.24272/j.issn.2095-8137.2023.199. | |
| Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. : | |
| Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197. | |
| Ryu, J., Statz, J.P., Chan, W., Oyama, K., Custer, M., Wienisch, M., Chen, R., Hanna, C.B., Hennebold, J.D. : | |
| Generation of rhesus macaque embryos with expanded CAG trinucleotide repeats in the Huntingtin gene. Cells 13:829, 2024. Pubmed reference: 38786052. DOI: 10.3390/cells13100829. | |
| 2023 | Upadhayay, S., Jamwal, S., Kumar, P. : |
| Animal models of Huntington's disease and their applicability to novel drug discovery and development. Expert Opin Drug Discov 18:527-538, 2023. Pubmed reference: 37042034. DOI: 10.1080/17460441.2023.2201493. | |
| Weiss, A.R., Liguore, W.A., Brandon, K., Wang, X., Liu, Z., Kroenke, C.D., McBride, J.L. : | |
| Alterations of fractional anisotropy throughout cortico-basal ganglia gray matter in a macaque model of Huntington's Disease. Curr Res Neurobiol 4:100090, 2023. Pubmed reference: 37397804. DOI: 10.1016/j.crneur.2023.100090. | |
| 2022 | Weiss, A.R., Liguore, W.A., Brandon, K., Wang, X., Liu, Z., Domire, J.S., Button, D., Srinivasan, S., Kroenke, C.D., McBride, J.L. : |
| A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline. Elife 11:e77568, 2022. Pubmed reference: 36205397. DOI: 10.7554/eLife.77568. | |
| 2021 | Khampang, S., Parnpai, R., Mahikul, W., Easley, C.A., Cho, I.K., Chan, A.W.S. : |
| CAG repeat instability in embryonic stem cells and derivative spermatogenic cells of transgenic Huntington's disease monkey. J Assist Reprod Genet 38:1215-1229, 2021. Pubmed reference: 33611676. DOI: 10.1007/s10815-021-02106-3. | |
| Yang, W., Chen, X., Li, S., Li, X.J. : | |
| Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8. | |
| 2020 | Howland, D., Ellederova, Z., Aronin, N., Fernau, D., Gallagher, J., Taylor, A., Hennebold, J., Weiss, A.R., Gray-Edwards, H., McBride, J. : |
| Large animal models of Huntington's disease: What we have learned and where we need to go next. J Huntingtons Dis 9:201-216, 2020. Pubmed reference: 32925082. DOI: 10.3233/JHD-200425. | |
| 2019 | Cho, I.K., Yang, B., Forest, C., Qian, L., Chan, A.W.S. : |
| Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys. PLoS One 14:e0214156, 2019. Pubmed reference: 30897183. DOI: 10.1371/journal.pone.0214156. | |
| Clever, F., Cho, I.K., Yang, J., Chan, A. : | |
| Progressive Polyglutamine Repeat Expansion in Peripheral Blood Cells and Sperm of Transgenic Huntington's Disease Monkeys. J Huntingtons Dis 8:443-448, 2019. Pubmed reference: 31561381. DOI: 10.3233/JHD-190359. | |
| 2018 | Snyder, B.R., Chan, A.W.S. : |
| Progress in developing transgenic monkey model for Huntington's disease. J Neural Transm (Vienna) 125:401-417, 2018. Pubmed reference: 29127484. DOI: 10.1007/s00702-017-1803-y. | |
| 2017 | Meng, Y., Jiang, J., Bachevalier, J., Zhang, X., Chan, A.W. : |
| Developmental Whole Brain White Matter Alterations in Transgenic Huntington's Disease Monkey. Sci Rep 7:379, 2017. Pubmed reference: 28336929. DOI: 10.1038/s41598-017-00381-8. | |
| 2015 | Chang, R., Liu, X., Li, S., Li, X.J. : |
| Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy. Drug Des Devel Ther 9:2179-88, 2015. Pubmed reference: 25931812. DOI: 10.2147/DDDT.S58470. | |
| Li, X.J., Li, S. : | |
| Large Animal Models of Huntington's Disease. Curr Top Behav Neurosci 22:149-60, 2015. Pubmed reference: 24048953. DOI: 10.1007/7854_2013_246. | |
| 2014 | Chan, A.W., Xu, Y., Jiang, J., Rahim, T., Zhao, D., Kocerha, J., Chi, T., Moran, S., Engelhardt, H., Larkin, K., Neumann, A., Cheng, H., Li, C., Nelson, K., Banta, H., Zola, S.M., Villinger, F., Yang, J., Testa, C.M., Mao, H., Zhang, X., Bachevalier, J. : |
| A two years longitudinal study of a transgenic Huntington disease monkey. BMC Neurosci 15:36, 2014. Pubmed reference: 24581271. DOI: 10.1186/1471-2202-15-36. | |
| 2013 | Laowtammathron, C., Chan, A.W. : |
| Pluripotent hybrid stem cells from transgenic Huntington's disease monkey. Methods Mol Biol 1010:61-77, 2013. Pubmed reference: 23754219. DOI: 10.1007/978-1-62703-411-1_5. | |
| 2008 | Yang, S.H., Cheng, P.H., Banta, H., Piotrowska-Nitsche, K., Yang, J.J., Cheng, E.C., Snyder, B., Larkin, K., Liu, J., Orkin, J., Fang, Z.H., Smith, Y., Bachevalier, J., Zola, S.M., Li, S.H., Li, X.J., Chan, A.W. : |
| Towards a transgenic model of Huntington's disease in a non-human primate. Nature 453:921-4, 2008. Pubmed reference: 18488016. DOI: 10.1038/nature06975. | |
| 1997 | Emerich, D.F., Winn, S.R., Hantraye, P.M., Peschanski, M., Chen, E.Y., Chu, Y., McDermott, P., Baetge, E.E., Kordower, J.H. : |
| Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 386:395-9, 1997. Pubmed reference: 9121555. DOI: 10.1038/386395a0. |
Edit History
- Created by Frank Nicholas on 30 Sep 2019
- Changed by Frank Nicholas on 30 Sep 2019
- Changed by Imke Tammen2 on 08 Apr 2021
- Changed by Imke Tammen2 on 09 Jan 2022
- Changed by Imke Tammen2 on 10 Dec 2023
- Changed by Imke Tammen2 on 20 Aug 2024