OMIA 000485-9940 : Huntington disease in Ovis aries

In other species: Rhesus monkey , pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 143100 (trait) , 613004 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Mears, E.R., Handley, R.R., Grant, M.J., Reid, S.J., Day, B.T., Rudiger, S.R., McLaughlan, C.J., Verma, P.J., Bawden, S.C., Patassini, S., Unwin, R.D., Cooper, G.J.S., Gusella, J.F., MacDonald, M.E., Brauning, R., Maclean, P., Pearson, J.F., Waldvogel, H.J., Faull, R.L.M., Snell, R.G. :
A multi-omic Huntington's disease transgenic sheep-model database for investigating disease pathogenesis. J Huntingtons Dis :, 2021. Pubmed reference: 34420978. DOI: 10.3233/JHD-210482.
Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2020 Howland, D., Ellederova, Z., Aronin, N., Fernau, D., Gallagher, J., Taylor, A., Hennebold, J., Weiss, A.R., Gray-Edwards, H., McBride, J. :
Large animal models of Huntington's disease: What we have learned and where we need to go next. J Huntingtons Dis 9:201-216, 2020. Pubmed reference: 32925082. DOI: 10.3233/JHD-200425.
2018 Pfister, E.L., DiNardo, N., Mondo, E., Borel, F., Conroy, F., Fraser, C., Gernoux, G., Han, X., Hu, D., Johnson, E., Kennington, L., Liu, P., Reid, S.J., Sapp, E., Vodicka, P., Kuchel, T., Morton, A.J., Howland, D., Moser, R., Sena-Esteves, M., Gao, G., Mueller, C., DiFiglia, M., Aronin, N. :
Artificial miRNAs reduce human mutant huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease. Hum Gene Ther 29:663-673, 2018. Pubmed reference: 29207890. DOI: 10.1089/hum.2017.199.
2014 Morton, A.J., Rudiger, S.R., Wood, N.I., Sawiak, S.J., Brown, G.C., Mclaughlan, C.J., Kuchel, T.R., Snell, R.G., Faull, R.L., Bawden, C.S. :
Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment. Hum Mol Genet 23:3375-83, 2014. Pubmed reference: 24488771. DOI: 10.1093/hmg/ddu047.
2013 Huntington's Disease Sheep Collaborative Research Group, Reid, S.J., Patassini, S., Handley, R.R., Rudiger, S.R., McLaughlan, C.J., Osmand, A., Jacobsen, J.C., Morton, A.J., Weiss, A., Waldvogel, H.J., MacDonald, M.E., Gusella, J.F., Bawden, C.S., Faull, R.L., Snell, R.G. :
Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates. J Huntingtons Dis 2:279-95, 2013. Pubmed reference: 25062676. DOI: 10.3233/JHD-130067.
2010 Jacobsen, J.C., Bawden, C.S., Rudiger, S.R., McLaughlan, C.J., Reid, S.J., Waldvogel, H.J., MacDonald, M.E., Gusella, J.F., Walker, S.K., Kelly, J.M., Webb, G.C., Faull, R.L., Rees, M.I., Snell, R.G. :
An ovine transgenic Huntington's disease model. Hum Mol Genet 19:1873-82, 2010. Pubmed reference: 20154343. DOI: 10.1093/hmg/ddq063.

Edit History

  • Created by Imke Tammen2 on 22 Aug 2021
  • Changed by Imke Tammen2 on 22 Aug 2021
  • Changed by Imke Tammen2 on 26 Aug 2021
  • Changed by Imke Tammen2 on 09 Jan 2022