OMIA:000494-9685 : Hyperadrenocorticism, generic in Felis catus (domestic cat)

In other species: dog , domestic ferret , horse , golden hamster

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 169170 (trait) , 201710 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Hyperadrenocorticism (or Cushing syndrome) refers to genetic and iatrogenic hypersecretion of adrenocorticotropic hormone (ACTH) (e.g. caused by tumours of either the pituitary or adrenal glands; or long-term administration of exogenous glucocorticoids). Entries for Cushing disease (pituitary-dependent hyperadrenocorticism) are included here and for some species also under the OMIA phene Cushing disease (OMIA:000247)

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2011). OMIA:000494-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2017 Boland, L.A., Barrs, V.R. :
Peculiarities of feline hyperadrenocorticism: Update on diagnosis and treatment. J Feline Med Surg 19:933-947, 2017. Pubmed reference: 28838299. DOI: 10.1177/1098612X17723245.
2011 Brown, A.L., Beatty, J.A., Lindsay, S.A., Barrs, V.R. :
Severe systemic hypertension in a cat with pituitary-dependent hyperadrenocorticism. J Small Anim Pract , 2011. Pubmed reference: 22129325. DOI: 10.1111/j.1748-5827.2011.01150.x.
2010 Spada, E., Proverbio, D., Giudice, C., DiGiancamillo, M., Lodi, M., Perego, R. :
Pituitary-dependent hyperadrenocorticism and generalised toxoplasmosis in a cat with neurological signs. J Feline Med Surg 12:654-8, 2010. Pubmed reference: 20466572. DOI: 10.1016/j.jfms.2010.01.014.
2006 Lien, Y.H., Huang, H.P., Chang, P.H. :
Iatrogenic hyperadrenocorticism in 12 cats. J Am Anim Hosp Assoc 42:414-23, 2006. Pubmed reference: 17088387.
2004 Meij, B.P., van der Vlugt-Meijer, R.H., van den Ingh, T.S., Rijnberk, A. :
Somatotroph and corticotroph pituitary adenoma (double adenoma) in a cat with diabetes mellitus and hyperadrenocorticism. J Comp Pathol 130:209-15, 2004. Pubmed reference: 15003481. DOI: 10.1016/j.jcpa.2003.09.004.
Neiger, R., Witt, A.L., Noble, A., German, A.J. :
Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats. J Vet Intern Med 18:160-4, 2004. Pubmed reference: 15058766.
2003 Skelly, B.J., Petrus, D., Nicholls, P.K. :
Use of trilostane for the treatment of pituitary-dependent hyperadrenocorticism in a cat Journal of Small Animal Practice 44:269-72, 2003. Pubmed reference: 12831104.
2002 Hoenig, M. :
Feline hyperadrenocorticism - where are we now ? Journal of Feline Medicine & Surgery 4:171-174, 2002.
Meij, B., Voorhout, G., Rijnberk, A. :
Progress in transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in dogs and cats Molecular & Cellular Endocrinology 197:89-96, 2002.
2001 Meij, B.P., Voorhout, G., Van Den Ingh, T.S., Rijnberk, A. :
Transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in 7 cats. Vet Surg 30:72-86, 2001. Pubmed reference: 11172463.
Stonehewer, J., Tasker, S. :
Hypoadrenocorticism in a cat Journal of Small Animal Practice 42:186-190, 2001. Pubmed reference: 11327666.
2000 Bruyette, D.S. :
An approach to diagnosing and treating feline hyperadrenocorticism Veterinary Medicine 95:142-148, 2000.
Bruyette, D.S. :
An approach to diagnosing and treating feline hyperadrenocorticism (vol 95, pg 142, 2000) Veterinary Medicine 95:287, 2000.
Moore, L.E., Biller, D.S., Olsen, D.E. :
Hyperadrenocorticism treated with metyrapone followed by bilateral adrenalectomy in a cat Journal of the American Veterinary Medical Association 217:691-+, 2000. Pubmed reference: 10976301.
Zerbe, C.A. :
Screening tests to diagnose hyperadrenocorticism in cats and dogs Compendium on Continuing Education for the Practicing Veterinarian 22:17-+, 2000.
1999 Boord, M., Griffin, C. :
Progesterone secreting adrenal mass in a cat with clinical signs of hyperadrenocorticism Journal of the American Veterinary Medical Association 214:666-669, 1999. Pubmed reference: 10088015.
1998 Watson, P.J., Herrtage, M.E. :
Hyperadrenocorticism in six cats Journal of Small Animal Practice 39:175-184, 1998. Pubmed reference: 9577759.
1997 Duesberg, C., Peterson, M.E. :
Adrenal disorders in cats Veterinary Clinics of North America - Small Animal Practice 27:321 ff., 1997.
Schwedes, C.S. :
Mitotane (o,p'-ddd) treatment in a cat with hyperadrenocorticism Journal of Small Animal Practice 38:520-524, 1997. Pubmed reference: 9403812.
1996 Valentine, R.W., Silber, A. :
Feline hyperadrenocorticism - a rare case Feline Practice 24:6-11, 1996.
1995 Duesberg, C.A., Nelson, R.W., Feldman, E.C., Vaden, S.L., Scottmoncrieff, J.C.R. :
Adrenalectomy for treatment of hyperadrenocorticism in cats - 10 cases (1988-1992) Journal of the American Veterinary Medical Association 207:1066-1070, 1995. Pubmed reference: 7559048.
Goossens, M.M.C., Meyer, H.P., Voorhout, G., Sprang, E.P.M. :
Urinary excretion of glucocorticoids in the diagnosis of hyperadrenocorticism in cats Domestic Animal Endocrinology 12:355-362, 1995. Pubmed reference: 8575168.
Widmer, W.R., Guptill, L. :
Clinical update - Imaging techniques for facilitating diagnosis of hyperadrenocorticism in dogs and cats Journal of the American Veterinary Medical Association 206:1857-1864, 1995. Pubmed reference: 7790297.
1994 Myers, N.C., Bruyette, D.S. :
Feline adrenocortical diseases: Part I--Hyperadrenocorticism. Semin Vet Med Surg (Small Anim) 9:137-43, 1994. Pubmed reference: 7938933.
1993 Daley, C.A., Zerbe, C.A., Schick, R.O., Powers, R.D. :
Use of metyrapone to treat pituitary-dependent hyperadrenocorticism in a cat with large cutaneous wounds. J Am Vet Med Assoc 202:956-60, 1993. Pubmed reference: 8468223.
1992 Furuzawa, Y., Une, Y., Nomura, Y. :
Pituitary dependent hyperadrenocorticism in a cat. J Vet Med Sci 54:1201-3, 1992. Pubmed reference: 1477172.
Immink, W.F., van Toor, A.J., Vos, J.H., van der Linde-Sipman, J.S., Lubberink, A.A. :
Hyperadrenocorticism in four cats. Vet Q 14:81-5, 1992. Pubmed reference: 1413443.
van Sluijs, F.J., Sjollema, B.E. :
Adrenalectomy in 36 dogs and 2 cats with hyperadrenocorticism. Tijdschr Diergeneeskd :29S, 1992. Pubmed reference: 1585317.
1991 Usher, D.G. :
Hyperadrenocorticism in a Cat Canadian Veterinary Journal-Revue Veterinaire Canadienne 32:326, 1991.
1990 Mauldin, G.N., Burk, R.L. :
The use of diagnostic computerized tomography and radiation therapy in canine and feline hyperadrenocorticism. Probl Vet Med 2:557-64, 1990. Pubmed reference: 2134074.
1988 Nelson, R.W., Feldman, E.C., Smith, M.C. :
Hyperadrenocorticism in cats: seven cases (1978-1987). J Am Vet Med Assoc 193:245-50, 1988. Pubmed reference: 2841269.
1987 Zerbe, C.A., Nachreiner, R.F., Dunstan, R.W., Dalley, J.B. :
Hyperadrenocorticism in a cat. J Am Vet Med Assoc 190:559-63, 1987. Pubmed reference: 3558096.
1986 Peterson, M.E., Steele, P. :
Pituitary-dependent hyperadrenocorticism in a cat. J Am Vet Med Assoc 189:680-3, 1986. Pubmed reference: 3019973.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 03 Dec 2011