OMIA 000496-27679 : Hyperbilirubinaemia I in Saimiri boliviensis

In other species: horse , sheep

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 143500 (trait) , 191740 (gene) , 218800 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Bilirubin is an orange bile pigment produced by the breakdown of haem and reduction of biliverdinin. An excess of bilirubin in the blood, resulting from a defect in uptake of organic anions by the liver, is called hyperbilirubinaemia I or Gilbert's syndrome. Another anion unable to be taken up by affected livers is phylloerythrin, a metabolite of chlorophyll. The resultant high blood levels of phylloerythrin result in photosensitive dermatitis. [Researched by Philippa Beard]


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1993 Cornelius, C.E. :
Fasting hyperbilirubinemia in Bolivian squirrel monkeys with a Gilbert's-like syndrome. Adv Vet Sci Comp Med 37:127-47, 1993. Pubmed reference: 8273512.
1992 Cornelius, C.E., Freedland, R.A. :
Fasting hyperbilirubinemia in normal squirrel monkeys. Lab Anim Sci 42:35-7, 1992. Pubmed reference: 1316506.
1991 Freedland, R.A., Smith, C.A., Bruss, M.L., Cornelius, C.E. :
Kinetic properties of bilirubin UDP-glucuronyltransferase in squirrel monkeys exhibiting fasting hyperbilirubinemia. Int J Biochem 23:867-73, 1991. Pubmed reference: 1773892.
1990 Myers, B.A., Lawton, M.P., Ruegg, C.L., Bruss, M.L., Cornelius, C.E. :
Hepatic bilirubin and UDP-glucuronate levels in Bolivian squirrel monkeys exhibiting fasting hyperbilirubinemia. Int J Biochem 22:61-5, 1990. Pubmed reference: 2109708.
Rodgers, P.A., Cornelius, C.E., Vreman, H.J., Tarkington, B.K. :
Increased carbon monoxide excretion in Bolivian squirrel monkeys with fasting hyperbilirubinemia. J Med Primatol 19:485-92, 1990. Pubmed reference: 2213857.

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  • Created by Frank Nicholas on 29 Nov 2011