OMIA:000499-10036 : Hypercholesterolaemia in Mesocricetus auratus |
In other species: dog , pig , rabbit
Categories: Homeostasis / metabolism phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 143890 (trait) , 606945 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Cross-species summary: see also OMIA 001160: Hyperlipidaemia
Species-specific description: Guo et al. (2018) "generated Ldlr-ablated hamsters using CRISPR/Cas9 technology". Thus these animals are genetically-modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| Ldlr | low density lipoprotein receptor | Mesocricetus auratus | NW_024429203.1 (1975372..2000518) | Ldlr | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2021 | Lin, X., Ma, P., Yang, C., Wang, J., He, K., Chen, G., Huang, W., Fan, J., Xian, X., Wang, Y., Liu, G. : |
| Dietary-induced elevations of triglyceride-rich lipoproteins promote atherosclerosis in the low-density lipoprotein receptor knockout Syrian golden hamster. Front Cardiovasc Med 8:738060, 2021. Pubmed reference: 34796210 . DOI: 10.3389/fcvm.2021.738060. | |
| 2019 | Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X., Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X. : |
| Dietary cholesterol is highly associated with severity of hyperlipidemia and atherosclerotic lesions in heterozygous LDLR-deficient hamsters. Int J Mol Sci 20:3515, 2019. Pubmed reference: 31323736 . DOI: 10.3390/ijms20143515. | |
| 2018 | Guo, X., Gao, M., Wang, Y., Lin, X., Yang, L., Cong, N., An, X., Wang, F., Qu, K., Yu, L., Wang, Y., Wang, J., Zhu, H., Xian, X., Liu, G. : |
| LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis. EBioMedicine 27:214-224, 2018. Pubmed reference: 29289533 . DOI: 10.1016/j.ebiom.2017.12.013. |
Edit History
- Created by Frank Nicholas on 21 Sep 2019
- Changed by Frank Nicholas on 21 Sep 2019