OMIA 000499-10036 : Hypercholesterolaemia in Mesocricetus auratus

In other species: dog , pig , rabbit

Possibly relevant human trait(s) and/or gene(s) (MIM number): 143890

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Guo et al. (2018) "generated Ldlr-ablated hamsters using CRISPR/Cas9 technology". Thus these animals are genetically-modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
Ldlr low density lipoprotein receptor Mesocricetus auratus - no genomic information (-..-) Ldlr Homologene, Ensembl, NCBI gene


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X., Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X. :
Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters. Int J Mol Sci 20:, 2019. Pubmed reference: 31323736. DOI: 10.3390/ijms20143515.
2018 Guo, X., Gao, M., Wang, Y., Lin, X., Yang, L., Cong, N., An, X., Wang, F., Qu, K., Yu, L., Wang, Y., Wang, J., Zhu, H., Xian, X., Liu, G. :
LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis. EBioMedicine 27:214-224, 2018. Pubmed reference: 29289533. DOI: 10.1016/j.ebiom.2017.12.013.

Edit History

  • Created by Frank Nicholas on 21 Sep 2019
  • Changed by Frank Nicholas on 21 Sep 2019